FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109595931> ?p ?o ?g. }

• W3109595931 endingPage "5648" @default.
• W3109595931 startingPage "5648" @default.
• W3109595931 abstract "Production of monoclonal antibodies (mAbs) is a well-known method used to synthesize a large number of identical antibodies, which are molecules of huge importance in medicine. Due to such reasons, intense efforts have been invested to maximize the mAbs production in bioreactors with hybridoma cell cultures. However, the optimal control of such sensitive bioreactors is an engineering problem difficult to solve due to the large number of state-variables with highly nonlinear dynamics, which often translates into a non-convex optimization problem that involves a significant number of decision (control) variables. Based on an adequate kinetic model adopted from the literature, this paper focuses on developing an in-silico (model-based, offline) numerical analysis of a fed-batch bioreactor (FBR) with an immobilized hybridoma culture to determine its optimal feeding policy by considering a small number of control variables, thus ensuring maximization of mAbs production. The obtained time stepwise optimal feeding policies of FBR were proven to obtain better performances than those of simple batch operation (BR) for all the verified alternatives in terms of raw material consumption and mAbs productivity. Several elements of novelty (i–iv) are pointed out in the “conclusions” section (e.g., considering the continuously added biomass as a control variable during FBR)." @default.
• W3109595931 created "2020-12-07" @default.
• W3109595931 creator A5088781488 @default.
• W3109595931 date "2020-11-30" @default.
• W3109595931 modified "2023-10-06" @default.
• W3109595931 title "Model-Based Optimization of a Fed-Batch Bioreactor for mAb Production Using a Hybridoma Cell Culture" @default.
• W3109595931 cites W1529344387 @default.
• W3109595931 cites W1537969468 @default.
• W3109595931 cites W1966293504 @default.
• W3109595931 cites W1968958277 @default.
• W3109595931 cites W1974222754 @default.
• W3109595931 cites W1983584318 @default.
• W3109595931 cites W1984072130 @default.
• W3109595931 cites W1987763243 @default.
• W3109595931 cites W1999276310 @default.
• W3109595931 cites W2000933864 @default.
• W3109595931 cites W2014167093 @default.
• W3109595931 cites W2022609647 @default.
• W3109595931 cites W2026501248 @default.
• W3109595931 cites W2029470963 @default.
• W3109595931 cites W2036160014 @default.
• W3109595931 cites W2038175194 @default.
• W3109595931 cites W2040404084 @default.
• W3109595931 cites W2050698012 @default.
• W3109595931 cites W2055685888 @default.
• W3109595931 cites W2067218604 @default.
• W3109595931 cites W2068831106 @default.
• W3109595931 cites W2073497702 @default.
• W3109595931 cites W2078299259 @default.
• W3109595931 cites W2107865859 @default.
• W3109595931 cites W2129583379 @default.
• W3109595931 cites W2138362688 @default.
• W3109595931 cites W2151738198 @default.
• W3109595931 cites W2154397483 @default.
• W3109595931 cites W2168338758 @default.
• W3109595931 cites W2170618025 @default.
• W3109595931 cites W2387963193 @default.
• W3109595931 cites W2515713940 @default.
• W3109595931 cites W2581033000 @default.
• W3109595931 cites W2589500477 @default.
• W3109595931 cites W2591815481 @default.
• W3109595931 cites W2618814253 @default.
• W3109595931 cites W2790306592 @default.
• W3109595931 cites W2792590822 @default.
• W3109595931 cites W2792637043 @default.
• W3109595931 cites W2898049386 @default.
• W3109595931 cites W3007303229 @default.
• W3109595931 cites W4238991091 @default.
• W3109595931 cites W4252797978 @default.
• W3109595931 cites W2054173635 @default.
• W3109595931 doi "https://doi.org/10.3390/molecules25235648" @default.
• W3109595931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7729860" @default.
• W3109595931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33266156" @default.
• W3109595931 hasPublicationYear "2020" @default.
• W3109595931 type Work @default.
• W3109595931 sameAs 3109595931 @default.
• W3109595931 citedByCount "7" @default.
• W3109595931 countsByYear W31095959312021 @default.
• W3109595931 countsByYear W31095959312022 @default.
• W3109595931 countsByYear W31095959312023 @default.
• W3109595931 crossrefType "journal-article" @default.
• W3109595931 hasAuthorship W3109595931A5088781488 @default.
• W3109595931 hasBestOaLocation W31095959311 @default.
• W3109595931 hasConcept C100544194 @default.
• W3109595931 hasConcept C104317684 @default.
• W3109595931 hasConcept C119857082 @default.
• W3109595931 hasConcept C126255220 @default.
• W3109595931 hasConcept C127413603 @default.
• W3109595931 hasConcept C139719470 @default.
• W3109595931 hasConcept C150903083 @default.
• W3109595931 hasConcept C153240184 @default.
• W3109595931 hasConcept C159654299 @default.
• W3109595931 hasConcept C162324750 @default.
• W3109595931 hasConcept C167431671 @default.
• W3109595931 hasConcept C168170006 @default.
• W3109595931 hasConcept C178790620 @default.
• W3109595931 hasConcept C183696295 @default.
• W3109595931 hasConcept C185592680 @default.
• W3109595931 hasConcept C203014093 @default.
• W3109595931 hasConcept C2775905019 @default.
• W3109595931 hasConcept C2776330181 @default.
• W3109595931 hasConcept C2778348673 @default.
• W3109595931 hasConcept C33923547 @default.
• W3109595931 hasConcept C41008148 @default.
• W3109595931 hasConcept C542903549 @default.
• W3109595931 hasConcept C55493867 @default.
• W3109595931 hasConcept C86803240 @default.
• W3109595931 hasConceptScore W3109595931C100544194 @default.
• W3109595931 hasConceptScore W3109595931C104317684 @default.
• W3109595931 hasConceptScore W3109595931C119857082 @default.
• W3109595931 hasConceptScore W3109595931C126255220 @default.
• W3109595931 hasConceptScore W3109595931C127413603 @default.
• W3109595931 hasConceptScore W3109595931C139719470 @default.
• W3109595931 hasConceptScore W3109595931C150903083 @default.
• W3109595931 hasConceptScore W3109595931C153240184 @default.
• W3109595931 hasConceptScore W3109595931C159654299 @default.
• W3109595931 hasConceptScore W3109595931C162324750 @default.
• W3109595931 hasConceptScore W3109595931C167431671 @default.

• next