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• W3109629340 abstract "Aim: To investigate the role of epigenetics in HIV pathophysiology. Materials & methods: We conducted an epigenome-wide association scan on HIV infection status among people who inject drugs in the AIDS Linked to the IntraVenous Experience study with primary (n = 397) and validation samples (n = 390). DNA methylation from blood was measured by the Illumina EPIC BeadChip. We controlled for cell type heterogeneity by HIV status. Results: HIV infection status was associated (p < 10 -8 ) with DNA methylation at 49 CpG sites. Sites were enriched in response to virus, interferon signaling pathway, etc. Among these sites, discovery and validation t-statistics were highly correlated (r = 0.96). Conclusion: In a cohort of people who inject drugs, HIV status was associated with differential DNA methylation at biologically meaningful sites." @default.
• W3109629340 created "2020-12-07" @default.
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• W3109629340 date "2020-11-01" @default.
• W3109629340 modified "2023-10-02" @default.
• W3109629340 title "Epigenome-wide association scan identifies methylation sites associated with HIV infection" @default.
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• W3109629340 doi "https://doi.org/10.2217/epi-2020-0123" @default.
• W3109629340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7788472" @default.
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