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- W3109643438 endingPage "473" @default.
- W3109643438 startingPage "453" @default.
- W3109643438 abstract "Significance: There is still no cure for neurodegenerative diseases, such as Parkinson's disease (PD). Current treatments are based on the attempt to reduce dopaminergic neuronal loss, and multidisciplinary approaches have been used to provide only a temporary symptoms' relief. In addition to the difficulties of drugs developed against PD to access the brain, the specificity of those inhibitory compounds could be a concern. This because neurons might degenerate by activating distinct signaling pathways, which are often initiated by the same stimulus. Recent Advances: Apoptosis, necroptosis, and ferroptosis were shown to significantly contribute to PD progression and, so far, are the main death programs described as capable to alter brain homeostasis. Their activation is characterized by different biochemical and morphological features, some of which might even share the same molecular players. Critical Issues: If there is a pathological need to engage, in PD, multiple death programs, sequentially or simultaneously, is not clear yet. Possibly the activation of apoptosis, necroptosis, and/or ferroptosis correlates to different PD stages and symptom severities. This would imply that the efficacy of therapeutic approaches against neuronal death might depend on the death program they target and the relevance of this death pathway on a specific PD phase. Future Directions: In this review, we describe the molecular mechanisms underlying the activation of apoptosis, necroptosis, and ferroptosis in PD. Understanding the interrelationship between different death pathways' activation in PD is of utmost importance for the development of therapeutic approaches against disease progression. Antioxid. Redox Signal. 35, 453-473." @default.
- W3109643438 created "2020-12-07" @default.
- W3109643438 creator A5030632496 @default.
- W3109643438 creator A5033159135 @default.
- W3109643438 creator A5056529696 @default.
- W3109643438 creator A5073316472 @default.
- W3109643438 creator A5076388205 @default.
- W3109643438 date "2021-08-20" @default.
- W3109643438 modified "2023-10-01" @default.
- W3109643438 title "Cell Death-Osis of Dopaminergic Neurons and the Role of Iron in Parkinson's Disease" @default.
- W3109643438 cites W1535426243 @default.
- W3109643438 cites W1548043092 @default.
- W3109643438 cites W1568912715 @default.
- W3109643438 cites W1589007430 @default.
- W3109643438 cites W1594017532 @default.
- W3109643438 cites W1597066001 @default.
- W3109643438 cites W1639349134 @default.
- W3109643438 cites W1836372348 @default.
- W3109643438 cites W1838017855 @default.
- W3109643438 cites W1913653254 @default.
- W3109643438 cites W1918300566 @default.
- W3109643438 cites W1966920840 @default.
- W3109643438 cites W1969515779 @default.
- W3109643438 cites W1969974411 @default.
- W3109643438 cites W1970878884 @default.
- W3109643438 cites W1975593978 @default.
- W3109643438 cites W1975774284 @default.
- W3109643438 cites W1977027824 @default.
- W3109643438 cites W1978895733 @default.
- W3109643438 cites W1980042430 @default.
- W3109643438 cites W1980462656 @default.
- W3109643438 cites W1981288060 @default.
- W3109643438 cites W1982303937 @default.
- W3109643438 cites W1986836235 @default.
- W3109643438 cites W1986978728 @default.
- W3109643438 cites W1990098732 @default.
- W3109643438 cites W1992435213 @default.
- W3109643438 cites W1993256031 @default.
- W3109643438 cites W1993281102 @default.
- W3109643438 cites W1994322539 @default.
- W3109643438 cites W1994548914 @default.
- W3109643438 cites W1997183854 @default.
- W3109643438 cites W2000087607 @default.
- W3109643438 cites W2002490399 @default.
- W3109643438 cites W2004628001 @default.
- W3109643438 cites W2007794772 @default.
- W3109643438 cites W2010354804 @default.
- W3109643438 cites W2011538447 @default.
- W3109643438 cites W2016833889 @default.
- W3109643438 cites W2021912535 @default.
- W3109643438 cites W2023122823 @default.
- W3109643438 cites W2025048194 @default.
- W3109643438 cites W2025161139 @default.
- W3109643438 cites W2030857589 @default.
- W3109643438 cites W2032656951 @default.
- W3109643438 cites W2037233527 @default.
- W3109643438 cites W2041184080 @default.
- W3109643438 cites W2041992874 @default.
- W3109643438 cites W2044627978 @default.
- W3109643438 cites W2046864536 @default.
- W3109643438 cites W2049359499 @default.
- W3109643438 cites W2049587638 @default.
- W3109643438 cites W2050781983 @default.
- W3109643438 cites W2050849483 @default.
- W3109643438 cites W2052853635 @default.
- W3109643438 cites W2053125535 @default.
- W3109643438 cites W2055285423 @default.
- W3109643438 cites W2057364502 @default.
- W3109643438 cites W2058436322 @default.
- W3109643438 cites W2060204808 @default.
- W3109643438 cites W2062853648 @default.
- W3109643438 cites W2062991497 @default.
- W3109643438 cites W2064111855 @default.
- W3109643438 cites W2064702079 @default.
- W3109643438 cites W2064996887 @default.
- W3109643438 cites W2065545181 @default.
- W3109643438 cites W2066912376 @default.
- W3109643438 cites W2068287502 @default.
- W3109643438 cites W2073449985 @default.
- W3109643438 cites W2073803664 @default.
- W3109643438 cites W2077317536 @default.
- W3109643438 cites W2078141613 @default.
- W3109643438 cites W2085641738 @default.
- W3109643438 cites W2088791795 @default.
- W3109643438 cites W2089518139 @default.
- W3109643438 cites W2090898691 @default.
- W3109643438 cites W2091363184 @default.
- W3109643438 cites W2096298540 @default.
- W3109643438 cites W2099819774 @default.
- W3109643438 cites W2104704429 @default.
- W3109643438 cites W2104965614 @default.
- W3109643438 cites W2106466768 @default.
- W3109643438 cites W2109963281 @default.
- W3109643438 cites W2110569992 @default.
- W3109643438 cites W2112203605 @default.
- W3109643438 cites W2112675104 @default.
- W3109643438 cites W2112867510 @default.
- W3109643438 cites W2113017807 @default.