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- W3109644393 abstract "Summary Nucleocapsid protein (N) is the most abundant viral protein encoded by SARS-CoV-2, the causative agent of COVID-19. N plays key roles at different steps in the replication cycle and is used as a serological marker of infection. Here we characterize the biochemical properties of SARS-CoV-2 N. We define the N domains important for oligomerization and RNA binding that are associated with spherical droplet formation and suggest that N accessibility and assembly may be regulated by phosphorylation. We also map the RNA binding interface using hydrogen-deuterium exchange mass spectrometry. Finally, we find that the N protein C-terminal domain is the most immunogenic by sensitivity, based upon antibody binding to COVID-19 patient samples from the US and Hong Kong. Together, these findings uncover domain-specific insights into the significance of SARS-CoV-2 N and highlight the diagnostic value of using N domains as highly specific and sensitive markers of COVID-19." @default.
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- W3109644393 date "2020-11-30" @default.
- W3109644393 modified "2023-09-30" @default.
- W3109644393 title "Characterization of SARS-CoV-2 N protein reveals multiple functional consequences of the C-terminal domain" @default.
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- W3109644393 doi "https://doi.org/10.1101/2020.11.30.404905" @default.
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