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- W3109668426 abstract "Abstract Background: Hu Qian Wan decoction (HQWD) is a traditional Chinese medicine used to treat many orthopedic diseases, including osteoporosis and osteoarthritis. This study aims to explore the mechanism by which HQWD promotes tendon-bone healing in the rotator cuff. Methods: Tendon-bone healing of the rotator cuff, serum exosome expression, and changes in interleukin-1 receptor antagonist (IL-1RA) in exosomes were analyzed after intragastric administration of HQWD in the rotator cuff reconstruction model of rats. The effects of Hu Qian Wan (HQW) on exosomes, IL-1RA, and Nod-like receptor protein 3 (NLRP3) secretion were verified in rat bone marrow mesenchymal stem cells (BMSCs) and macrophage cells, and the effects of HQW on inflammasomes were observed. Results: HQWD intragastric administration increased proteoglycan and collagen Ⅰ (Col Ⅰ) expression in the tendon-bone interface, improved the tendon-bone interface area, and augmented the maximum breaking load and stiffness of the rotator cuff. HQWD intragastric administration also increased rat exosome and IL-1RA expression in vivo. HQW promoted exosome and IL-1RA expression and suppressed the activation of NLRP3 inflammasomes in rat BMSCs and macrophage cells in vitro. Conclusions: HQWD inhibited inflammasome-related inflammation by inducing exosome and IL-1RA secretion in rats, thus, promoting tendon-bone healing of the rotator cuff." @default.
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- W3109668426 date "2020-11-12" @default.
- W3109668426 modified "2023-10-16" @default.
- W3109668426 title "Hu Qian Wan Decoction Promotes Tendon-bone Healing of the Rotator Cuff in Rats by Inducing the Release of Exosomes Containing Interleukin-1 Receptor Antagonists" @default.
- W3109668426 doi "https://doi.org/10.21203/rs.3.rs-104134/v1" @default.
- W3109668426 hasPublicationYear "2020" @default.
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