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• W3109695655 abstract "The inflammatory response to COVID-19 is specifically associated with an impaired type I interferon (IFN) response and complete blockade of IFN-β secretion. Clinically, nebulization of IFN-α-2b has been historically used in China to treat viral pneumonia associated with SARS-CoV. Very recent data show that the use of inhaled type I IFN is associated with decreased mortality in Chinese COVID-19 patients. However, IFN nebulization is currently not standard in Europe and the United States. Therefore, our group has set up a project aimed to evaluate the possibility to nebulize IFN-β-1b (a drug currently used in Europe to treat multiple sclerosis via subcutaneous injections) and to assess the safety of this new mode of administration in SARS-CoV-2 infected patients. We present here literature data that allowed us to build our hypothesis and to develop collaboration between clinical pharmacists, intensivists and nebulization engineers in order to gain first pre-clinical and clinical experience of IFN-β-1b nebulization. After validation of the nebulization method and verification of droplet size compatible with nebulization, the method has been applied to four intensive care patients treated at our university hospital, for whom none of the COVID-19 therapies initially used in France led to significant clinical improvement. All patients exhibited negative viral carriage and experienced clinical improvement 7–16 days after having initiated nebulized IFN-β-1b inhalation therapy. No side effects were observed. All patients were alive within a 90-days follow-up. Although it is not possible to draw firm conclusions on treatment efficacy based on this case report, our study shows that pulmonary IFN-β-1b administration is feasible, with a good safety profile. This procedure, which presents the advantage of directly targeting the lungs and reducing the risks of systemic side effects, may represent a promising therapeutic strategy for the care of patients with severe COVID-19. However, our preliminary observation requires confirmation by randomized controlled trials." @default.
• W3109695655 created "2020-12-07" @default.
• W3109695655 creator A5011918835 @default.
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• W3109695655 date "2020-11-30" @default.
• W3109695655 modified "2023-10-18" @default.
• W3109695655 title "Rationale for COVID-19 Treatment by Nebulized Interferon-β-1b–Literature Review and Personal Preliminary Experience" @default.
• W3109695655 cites W1968951658 @default.
• W3109695655 cites W1984064716 @default.
• W3109695655 cites W1984583580 @default.
• W3109695655 cites W1986107968 @default.
• W3109695655 cites W1988718462 @default.
• W3109695655 cites W1998944697 @default.
• W3109695655 cites W2008025282 @default.
• W3109695655 cites W2019472095 @default.
• W3109695655 cites W2024479430 @default.
• W3109695655 cites W2036270401 @default.
• W3109695655 cites W2040774216 @default.
• W3109695655 cites W2063929317 @default.
• W3109695655 cites W2066271685 @default.
• W3109695655 cites W2069125274 @default.
• W3109695655 cites W2077854494 @default.
• W3109695655 cites W2080955906 @default.
• W3109695655 cites W2088499363 @default.
• W3109695655 cites W2118194631 @default.
• W3109695655 cites W2118922852 @default.
• W3109695655 cites W2150961146 @default.
• W3109695655 cites W2152309517 @default.
• W3109695655 cites W2172359429 @default.
• W3109695655 cites W2173824042 @default.
• W3109695655 cites W2227974223 @default.
• W3109695655 cites W2314120200 @default.
• W3109695655 cites W2418688677 @default.
• W3109695655 cites W2589709778 @default.
• W3109695655 cites W2906753872 @default.
• W3109695655 cites W2943791673 @default.
• W3109695655 cites W2991017528 @default.
• W3109695655 cites W3001897055 @default.
• W3109695655 cites W3008028633 @default.
• W3109695655 cites W3009912996 @default.
• W3109695655 cites W3010079810 @default.
• W3109695655 cites W3010992334 @default.
• W3109695655 cites W3012379316 @default.
• W3109695655 cites W3012849736 @default.
• W3109695655 cites W3013524951 @default.
• W3109695655 cites W3014373288 @default.
• W3109695655 cites W3014604938 @default.
• W3109695655 cites W3016473145 @default.
• W3109695655 cites W3016489853 @default.
• W3109695655 cites W3016654445 @default.
• W3109695655 cites W3017982800 @default.
• W3109695655 cites W3018221920 @default.
• W3109695655 cites W3019343194 @default.
• W3109695655 cites W3021124063 @default.
• W3109695655 cites W3021565497 @default.
• W3109695655 cites W3021575042 @default.
• W3109695655 cites W3022171451 @default.
• W3109695655 cites W3022564719 @default.
• W3109695655 cites W3022961496 @default.
• W3109695655 cites W3023552416 @default.
• W3109695655 cites W3023606094 @default.
• W3109695655 cites W3024836217 @default.
• W3109695655 cites W3024946674 @default.
• W3109695655 cites W3025395896 @default.
• W3109695655 cites W3026764413 @default.
• W3109695655 cites W3027630905 @default.
• W3109695655 cites W3028410545 @default.
• W3109695655 cites W3030017458 @default.
• W3109695655 cites W3030478153 @default.
• W3109695655 cites W3030537287 @default.
• W3109695655 cites W3032373103 @default.
• W3109695655 cites W3033240553 @default.
• W3109695655 cites W3033272991 @default.
• W3109695655 cites W3033448316 @default.
• W3109695655 cites W3033997257 @default.
• W3109695655 cites W3034168389 @default.
• W3109695655 cites W3034434058 @default.
• W3109695655 cites W3034927885 @default.
• W3109695655 cites W3035137340 @default.
• W3109695655 cites W3035876959 @default.
• W3109695655 cites W3036347638 @default.
• W3109695655 cites W3036700224 @default.
• W3109695655 cites W3036912690 @default.
• W3109695655 cites W3037578804 @default.
• W3109695655 cites W3038048336 @default.
• W3109695655 cites W3038239479 @default.
• W3109695655 cites W3039656498 @default.
• W3109695655 cites W3040295653 @default.
• W3109695655 cites W3041206342 @default.
• W3109695655 cites W3041278562 @default.
• W3109695655 cites W3041960835 @default.
• W3109695655 cites W3042021285 @default.
• W3109695655 cites W3042144584 @default.

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