FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109736645> ?p ?o ?g. }

• W3109736645 endingPage "905" @default.
• W3109736645 startingPage "903" @default.
• W3109736645 abstract "It is still unclear if the ability of key regulators of actin cytoskeletal remodeling to influence lipid metabolism contributes to kidney injury. In this issue of Cell Metabolism, Fu et al., 2020Fu Y. Sun Y. Wang M. Hou Y. Huang W. Zhou D. Wang Z. Yang S. Tang W. Zhen J. et al.Elevation of JAML promotes diabetic kidney disease by modulating podocyte lipid metabolism.Cell Metab. 2020; 32 (this issue): 1052-1062Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar show that junctional adhesion molecule-like (JAML) is a novel mediator of glomerular disease progression while suggesting a direct link between defects in cell adhesion and lipotoxicity. It is still unclear if the ability of key regulators of actin cytoskeletal remodeling to influence lipid metabolism contributes to kidney injury. In this issue of Cell Metabolism, Fu et al., 2020Fu Y. Sun Y. Wang M. Hou Y. Huang W. Zhou D. Wang Z. Yang S. Tang W. Zhen J. et al.Elevation of JAML promotes diabetic kidney disease by modulating podocyte lipid metabolism.Cell Metab. 2020; 32 (this issue): 1052-1062Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar show that junctional adhesion molecule-like (JAML) is a novel mediator of glomerular disease progression while suggesting a direct link between defects in cell adhesion and lipotoxicity. The glomerulus acts as a selective-size filter within the kidney to remove toxic compounds from the blood. Glomerular diseases, whether primary or secondary to systemic disorders such as diabetes, account for a large number of cases of chronic kidney disease, a condition that affects millions of patients worldwide. In addition to several hemodynamic and metabolic mediators of glomerular injury, recent emphasis has been placed on the role of glomerular lipid dysmetabolism in these conditions. In particular, podocytes, which are functionally specialized and terminally differentiated cells of the glomerular filtration barrier, are highly sensitive to lipotoxicity. Podocyte loss is an irreversible phenomenon that has been found to predict disease progression across a spectrum of clinical and experimental models of glomerular disorders. The maintenance of proper podocyte actin cytoskeletal dynamics has long been recognized as a key to proper podocyte function and as a potential therapeutic target across several models of kidney disease (Schiffer et al., 2015Schiffer M. Teng B. Gu C. Shchedrina V.A. Kasaikina M. Pham V.A. Hanke N. Rong S. Gueler F. Schroder P. et al.Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.Nat. Med. 2015; 21: 601-609Crossref PubMed Scopus (77) Google Scholar). Under physiological conditions, podocytes rely primarily on anaerobic glucose metabolism for energy homeostasis and to a lesser extent on β-oxidation of lipids. Dysregulated lipid metabolism leading to the accumulation of cholesterol or to elevated levels of intracellular free fatty acids has been shown to contribute to lipotoxicity-induced podocyte injury, and to be associated with mitochondrial dysfunction (Ducasa et al., 2019Ducasa G.M. Mitrofanova A. Mallela S.K. Liu X. Molina J. Sloan A. Pedigo C.E. Ge M. Santos J.V. Hernandez Y. et al.ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes.J. Clin. Invest. 2019; 129: 3387-3400Crossref PubMed Scopus (33) Google Scholar). Interestingly, there seems to be a vicious cycle between mitochondrial dysfunction, inflammation, and altered lipid metabolism in podocytes (Figure 1). Altered cellular lipid metabolism and accumulation of lipid droplets in association with mitochondrial dysfunction and/or inflammation occurs in a variety of tissues, including, but not limited to, the kidney, adipose tissue, liver, and brain, thus contributing to many age-related metabolic and non-metabolic diseases such as kidney disease, atherosclerosis, Alzheimer’s disease, Parkinson’s disease, cardiovascular diseases, age-related macular degeneration, and others. Recently, mammalian lipid droplets have been demonstrated to be innate immune hubs that integrate cell metabolism and host defense, highlighting once more an active role of intracellular lipids as key modulators of cell function and survival (Bosch et al., 2020Bosch M. Sánchez-Álvarez M. Fajardo A. Kapetanovic R. Steiner B. Dutra F. Moreira L. López J.A. Campo R. Marí M. et al.Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.Science. 2020; 370: eaay8085Crossref PubMed Scopus (33) Google Scholar). While the interplay between renal lipids, mitochondrial dysfunction, and inflammation has been studied, the interplay between lipids and the actin cytoskeleton is less well understood. Recent work demonstrated a link between RhoA-dependent acto-myosin contraction and SREPBP1 activation (Bertolio et al., 2019Bertolio R. Napoletano F. Mano M. Maurer-Stroh S. Fantuz M. Zannini A. Bicciato S. Sorrentino G. Del Sal G. Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism.Nat. Commun. 2019; 10: 1326Crossref PubMed Scopus (50) Google Scholar), and decreased expression of phosphatase and tensin homolog (PTEN) was shown to inactivate cofilin-1 leading to F-actin formation and promoting the excessive lipid uptake by podocytes (Shi et al., 2020Shi Y. Wang C. Zhou X. Li Y. Ma Y. Zhang R. Li R. Downregulation of PTEN promotes podocyte endocytosis of lipids aggravating obesity-related glomerulopathy.Am. J. Physiol. Renal Physiol. 2020; 318: F589-F599Crossref PubMed Scopus (6) Google Scholar), suggesting that a similar viscious cycle between renal lipids and actin cytoskeleton remodeling might exist. In this issue of Cell Metabolism, a study by Fu et al., 2020Fu Y. Sun Y. Wang M. Hou Y. Huang W. Zhou D. Wang Z. Yang S. Tang W. Zhen J. et al.Elevation of JAML promotes diabetic kidney disease by modulating podocyte lipid metabolism.Cell Metab. 2020; 32 (this issue): 1052-1062Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar demonstrates that expression of junctional adhesion molecule-like (JAML), a protein shown to be localized at the plasma membrane in the areas of cell-cell contacts where it enhances cell adhesion of leukocytes to endothelial cells, is significantly induced in podocytes treated with sera obtained from patients with diabetic kidney disease (DKD) and by other stimuli present in diabetic milieu such as high glucose, palmitic acid, cholesterol, and oxidized low-density lipoprotein (ox-LDL). Additionally, JAML expression was found increased in the glomeruli of experimental models of DKD, and in glomeruli and sera of patients with DKD as well as of patients with focal and segmental glomerulosclerosis (FSGS) and membranous nephropathy (MN). More importantly, JAML expression positively correlated with serum creatinine and lipid accumulation and negatively correlated with the estimated glomerular filtration rate (a clinical readout of kidney function) in patients with DKD, while podocyte-specific genetic JAML deficiency attenuated lipid accumulation and renal dysfunction in two diabetic mouse models of DKD (namely, streptozocin high-fat-diet-fed and db/db mice). Finally, Sirt1 was identified as a key mediator linking JAML to AMP activated protein kinase/sterol regulatory element-binding protein 1 (AMPK/SREBP1) signaling, an interesting observation as a role for JAM family members in lipid metabolism was only recently discovered (Rahman et al., 2016Rahman K. Desai C. Iyer S.S. Thorn N.E. Kumar P. Liu Y. Smith T. Neish A.S. Li H. Tan S. et al.Loss of junctional adhesion molecule a promotes severe steatohepatitis in mice on a diet high in saturated fat, fructose, and cholesterol.Gastroenterology. 2016; 151: 733-746.e12Abstract Full Text Full Text PDF PubMed Scopus (132) Google Scholar). The primary effect of JAML on lipid species such as cholesteryl esters and free fatty acids accompanied by an increase in lipid droplets challenges the concept that lipid droplets are a cellular defense against lipotoxicity. It suggests instead that lipid droplets are very active scavenging organelles that can orchestrate the function of other organelles in response to stress by modulating storage and lipolysis across different subcellular compartments. While this study demonstrates a link between JAML and lipid metabolism, it does not address whether JAML directly affects actin dynamics via the AMPK pathway, similarly to what was recently described for TRPC6 in mediating insulin-dependent activation of AMPK, actin reorganization, and glucose uptake in podocytes (Rachubik et al., 2018Rachubik P. Szrejder M. Rogacka D. Audzeyenka I. Rychłowski M. Angielski S. Piwkowska A. The TRPC6-AMPK pathway is involved in insulin-dependent cytoskeleton reorganization and glucose uptake in cultured rat podocytes.Cell. Physiol. Biochem. 2018; 51: 393-410Crossref PubMed Scopus (19) Google Scholar). JAML may also indirectly influence the ability of lipid droplets to supply free cholesterol to plasma membranes, where key constituents of the glomerular filtration barrier such as podocin rely on cholesterol binding to function and transactivate other proteins, such as TRPC6. Sodium-glucose co-transporter 2 (SGLT2) inhibitors were recently found to be beneficial in patients with diabetes and kidney disease. While the renoprotective effects of these agents are thought to be related to glycosuria and to protection from glomerular hyperfiltration, the observation that they are also clinically beneficial in non-metabolic kidney diseases (Heerspink et al., 2020Heerspink H.J.L. Stefánsson B.V. Correa-Rotter R. Chertow G.M. Greene T. Hou F.F. Mann J.F.E. McMurray J.J.V. Lindberg M. Rossing P. et al.DAPA-CKD Trial Committees and InvestigatorsDapagliflozin in patients with chronic kidney disease.N. Engl. J. Med. 2020; 383: 1436-1446Crossref PubMed Scopus (434) Google Scholar) and that they induce AMPK and SIRT1 in adipocytes (Yang et al., 2020Yang X. Liu Q. Li Y. Tang Q. Wu T. Chen L. Pu S. Zhao Y. Zhang G. Huang C. et al.The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway.Adipocyte. 2020; 9: 484-494Crossref PubMed Scopus (13) Google Scholar) strongly suggests that renoprotection by SGLT2 inhibitors may be mediated through improved lipid metabolism and fatty acid oxidation. Understanding and identifying the key pathways contributing to podocyte injury is fundamental to the development of new therapeutic strategies for the treatment of patients with DKD and other glomerular diseases. The identification of JAML as a novel mediator contributing to glomerular disease progression and of its role in regulating lipid metabolism in podocytes further strengthens the concept that targeting cellular lipid metabolism may represent a novel therapeutic strategy for patients with glomerular diseases of metabolic and non-metabolic origin. Whether targeting JAML or lipid metabolism is sufficient to prevent glomerular disease progression in patients with glomerular diseases remains to be established. A.F. and S.M. are supported by NIH grants R01DK117599 , R01DK104753 , and R01CA227493 , and by Boehringer Ingelheim . A.F. is supported by NIH grants U54DK083912 , UM1DK100846 , U01DK116101 , and UL1TR000460 ( Miami Clinical Translational Science Institute , Translational Science Institute , from the National Center for Advancing Translational Sciences and the National Institute on Minority Health and Health Disparities ). We give a special thanks to the Katz family for their continuous support. Figure was created with https://biorender.com/. A.F. and S.M. are inventors on pending or issued patents (PCT/US11/56272, PCT/US12/62594, PCT/US2019/041730, PCT/US2019/032215, PCT/US13/36484, and PCT 62/674,897) aimed at diagnosing or treating proteinuric kidney diseases. They stand to gain royalties from their future commercialization of these patents. A.F. is Vice President of L&F Health LLC and is a consultant for ZyVersa Therapeutics, Inc. ZyVersa Therapeutics, Inc. has licensed worldwide rights to develop and commercialize hydroxypropyl-beta-cyclodextrin from L&F Research for the treatment of kidney disease. S.M. holds indirect equity interest in, and potential royalty from, ZyVersa Therapeutics, Inc. by virtue of assignment and licensure of a patent estate. Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid MetabolismFu et al.Cell MetabolismNovember 12, 2020In BriefFu et al. explore a role of JAML in mediating podocyte lipid metabolism and find that the level of JAML in glomeruli is correlated with lipid accumulation and glomerular filtration rate from subjects with podocytopathies including diabetic kidney disease, suggesting that JAML is a potential therapeutic target for kidney diseases. Full-Text PDF" @default.
• W3109736645 created "2020-12-07" @default.
• W3109736645 creator A5021600258 @default.
• W3109736645 creator A5065478151 @default.
• W3109736645 date "2020-12-01" @default.
• W3109736645 modified "2023-09-27" @default.
• W3109736645 title "Lipid Metabolism Gets in a JAML during Kidney Disease" @default.
• W3109736645 cites W1505771931 @default.
• W3109736645 cites W2464019961 @default.
• W3109736645 cites W2900499088 @default.
• W3109736645 cites W2924788077 @default.
• W3109736645 cites W2963804962 @default.
• W3109736645 cites W2996086188 @default.
• W3109736645 cites W3081001956 @default.
• W3109736645 cites W3088173406 @default.
• W3109736645 cites W3093010709 @default.
• W3109736645 cites W3100707630 @default.
• W3109736645 doi "https://doi.org/10.1016/j.cmet.2020.11.002" @default.
• W3109736645 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7978490" @default.
• W3109736645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33264600" @default.
• W3109736645 hasPublicationYear "2020" @default.
• W3109736645 type Work @default.
• W3109736645 sameAs 3109736645 @default.
• W3109736645 citedByCount "5" @default.
• W3109736645 countsByYear W31097366452021 @default.
• W3109736645 countsByYear W31097366452022 @default.
• W3109736645 countsByYear W31097366452023 @default.
• W3109736645 crossrefType "journal-article" @default.
• W3109736645 hasAuthorship W3109736645A5021600258 @default.
• W3109736645 hasAuthorship W3109736645A5065478151 @default.
• W3109736645 hasBestOaLocation W31097366451 @default.
• W3109736645 hasConcept C126322002 @default.
• W3109736645 hasConcept C2778653478 @default.
• W3109736645 hasConcept C2779134260 @default.
• W3109736645 hasConcept C2780091579 @default.
• W3109736645 hasConcept C4733338 @default.
• W3109736645 hasConcept C60644358 @default.
• W3109736645 hasConcept C62231903 @default.
• W3109736645 hasConcept C71924100 @default.
• W3109736645 hasConcept C86803240 @default.
• W3109736645 hasConceptScore W3109736645C126322002 @default.
• W3109736645 hasConceptScore W3109736645C2778653478 @default.
• W3109736645 hasConceptScore W3109736645C2779134260 @default.
• W3109736645 hasConceptScore W3109736645C2780091579 @default.
• W3109736645 hasConceptScore W3109736645C4733338 @default.
• W3109736645 hasConceptScore W3109736645C60644358 @default.
• W3109736645 hasConceptScore W3109736645C62231903 @default.
• W3109736645 hasConceptScore W3109736645C71924100 @default.
• W3109736645 hasConceptScore W3109736645C86803240 @default.
• W3109736645 hasFunder F4320332161 @default.
• W3109736645 hasIssue "6" @default.
• W3109736645 hasLocation W31097366451 @default.
• W3109736645 hasLocation W31097366452 @default.
• W3109736645 hasOpenAccess W3109736645 @default.
• W3109736645 hasPrimaryLocation W31097366451 @default.
• W3109736645 hasRelatedWork W2088525243 @default.
• W3109736645 hasRelatedWork W2127085070 @default.
• W3109736645 hasRelatedWork W2134764426 @default.
• W3109736645 hasRelatedWork W2412727020 @default.
• W3109736645 hasRelatedWork W2763360885 @default.
• W3109736645 hasRelatedWork W2888779279 @default.
• W3109736645 hasRelatedWork W2981884515 @default.
• W3109736645 hasRelatedWork W3003571257 @default.
• W3109736645 hasRelatedWork W4377262157 @default.
• W3109736645 hasRelatedWork W1556208436 @default.
• W3109736645 hasVolume "32" @default.
• W3109736645 isParatext "false" @default.
• W3109736645 isRetracted "false" @default.
• W3109736645 magId "3109736645" @default.
• W3109736645 workType "article" @default.