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- W3109737608 abstract "Summary After reprogramming to naïve pluripotency, human pluripotent stem cells (PSCs) still exhibit very low ability to make interspecies chimeras. Whether this is because they are inherently devoid of the attributes of chimeric competency or because naïve PSCs cannot colonize embryos from distant species remains to be elucidated. Here, we have used different types of mouse, human and rhesus monkey naïve PSCs and analyzed their ability to colonize rabbit and cynomolgus monkey embryos. Mouse embryonic stem cells (ESCs) remained mitotically active and efficiently colonized host embryos. In contrast, primate naïve PSCs colonized host embryos with much lower efficiency. Unlike mouse ESCs, they slowed DNA replication after dissociation and, after injection into host embryos, they stalled in the G1 phase and differentiated prematurely, regardless of host species. We conclude that human and non-human primate naïve PSCs do not efficiently make chimeras because they are inherently unfit to remain mitotically active during colonization." @default.
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- W3109737608 date "2020-03-28" @default.
- W3109737608 modified "2023-10-18" @default.
- W3109737608 title "Apoptosis, G1 phase stall and premature differentiation account for low chimeric competence of Human and rhesus monkey naïve pluripotent stem cells" @default.
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- W3109737608 doi "https://doi.org/10.1101/2020.03.27.011890" @default.
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