FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109739384> ?p ?o ?g. }

• W3109739384 abstract "Objective: To explore the prognostic significance of metabolic parameters in postoperative peritumoral edema zone (PEZ) of patients with glioblastoma (GBM) based on proton magnetic resonance spectroscopy (MRS). Methods: The postoperative MRS data of 67 patients with GBM from Beijing Tiantan Hospital were retrospectively reviewed. Metabolite ratios including Cho/NAA, Cho/Cr, and NAA/Cr in both postoperative PEZ and contralateral normal brain region were recorded. Log-rank analysis and Cox regression model were used to identify parameters correlated with progression-free survival (PFS) and overall survival (OS). Results: Compared with the contralateral normal brain region, postoperative PEZ showed a lower ratio of NAA/Cr (1.20 ± 0.42 vs. 1.81 ± 0.48, P &lt; 0.001), and higher ratios of Cho/Cr and Cho/NAA (1.36 ± 0.44 vs. 1.02 ± 0.27, P &lt; 0.001 and 1.32 ± 0.59 vs. 0.57 ± 0.14, P &lt; 0.001). Both the ratios of Cho/NAA and NAA/Cr were identified as prognostic factors in univariate analysis ( P &lt; 0.05), while only Cho/NAA ≥ 1.31 was further confirmed as an independent risk factor for early recurrence in the Cox regression model ( P &lt; 0.01). According to the factors of MGMT promoter unmethylation, without radiotherapy and Cho/NAA ≥ 1.31, a prognostic scoring scale for GBM was established, which could divide patients into low-risk, moderate-risk, and high-risk groups. There was a significant difference of survival rate between the three groups ( P &lt; 0.001). Conclusions: Higher Cho/NAA ratio in the postoperative PEZ of GBM predicts earlier recurrence and is associated with poor prognosis. The prognostic scoring scale based on clinical, molecular and metabolic parameters of patients with GBM can help doctors to make more precise prediction of survival time and to adjust therapeutic regimens." @default.
• W3109739384 created "2020-12-07" @default.
• W3109739384 creator A5010275776 @default.
• W3109739384 creator A5027433414 @default.
• W3109739384 creator A5031601007 @default.
• W3109739384 creator A5034594187 @default.
• W3109739384 creator A5040812179 @default.
• W3109739384 creator A5044411195 @default.
• W3109739384 creator A5064836803 @default.
• W3109739384 creator A5073698150 @default.
• W3109739384 date "2020-12-04" @default.
• W3109739384 modified "2023-10-16" @default.
• W3109739384 title "Higher Cho/NAA Ratio in Postoperative Peritumoral Edema Zone Is Associated With Earlier Recurrence of Glioblastoma" @default.
• W3109739384 cites W1582025213 @default.
• W3109739384 cites W1882450096 @default.
• W3109739384 cites W1968036283 @default.
• W3109739384 cites W1972922820 @default.
• W3109739384 cites W1981289067 @default.
• W3109739384 cites W1981701569 @default.
• W3109739384 cites W1988589887 @default.
• W3109739384 cites W1995577320 @default.
• W3109739384 cites W2005404299 @default.
• W3109739384 cites W2036455269 @default.
• W3109739384 cites W2042524329 @default.
• W3109739384 cites W2061104460 @default.
• W3109739384 cites W2066077295 @default.
• W3109739384 cites W2067429999 @default.
• W3109739384 cites W2091011326 @default.
• W3109739384 cites W2092906204 @default.
• W3109739384 cites W2096287682 @default.
• W3109739384 cites W2124984234 @default.
• W3109739384 cites W2131998659 @default.
• W3109739384 cites W2137220050 @default.
• W3109739384 cites W2139166593 @default.
• W3109739384 cites W2141464097 @default.
• W3109739384 cites W2146933354 @default.
• W3109739384 cites W2147746609 @default.
• W3109739384 cites W2152025703 @default.
• W3109739384 cites W2160382843 @default.
• W3109739384 cites W2167400606 @default.
• W3109739384 cites W2304430086 @default.
• W3109739384 cites W2366536035 @default.
• W3109739384 cites W2436534309 @default.
• W3109739384 cites W2512946501 @default.
• W3109739384 cites W2602025178 @default.
• W3109739384 cites W2606472788 @default.
• W3109739384 cites W2620142324 @default.
• W3109739384 cites W2938165912 @default.
• W3109739384 cites W2943892708 @default.
• W3109739384 cites W2945276566 @default.
• W3109739384 cites W4211132876 @default.
• W3109739384 cites W4250899941 @default.
• W3109739384 doi "https://doi.org/10.3389/fneur.2020.592155" @default.
• W3109739384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7747764" @default.
• W3109739384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33343496" @default.
• W3109739384 hasPublicationYear "2020" @default.
• W3109739384 type Work @default.
• W3109739384 sameAs 3109739384 @default.
• W3109739384 citedByCount "9" @default.
• W3109739384 countsByYear W31097393842021 @default.
• W3109739384 countsByYear W31097393842022 @default.
• W3109739384 countsByYear W31097393842023 @default.
• W3109739384 crossrefType "journal-article" @default.
• W3109739384 hasAuthorship W3109739384A5010275776 @default.
• W3109739384 hasAuthorship W3109739384A5027433414 @default.
• W3109739384 hasAuthorship W3109739384A5031601007 @default.
• W3109739384 hasAuthorship W3109739384A5034594187 @default.
• W3109739384 hasAuthorship W3109739384A5040812179 @default.
• W3109739384 hasAuthorship W3109739384A5044411195 @default.
• W3109739384 hasAuthorship W3109739384A5064836803 @default.
• W3109739384 hasAuthorship W3109739384A5073698150 @default.
• W3109739384 hasBestOaLocation W31097393841 @default.
• W3109739384 hasConcept C126322002 @default.
• W3109739384 hasConcept C126838900 @default.
• W3109739384 hasConcept C143409427 @default.
• W3109739384 hasConcept C144301174 @default.
• W3109739384 hasConcept C2776194525 @default.
• W3109739384 hasConcept C2777477808 @default.
• W3109739384 hasConcept C2780886150 @default.
• W3109739384 hasConcept C2989005 @default.
• W3109739384 hasConcept C38180746 @default.
• W3109739384 hasConcept C502942594 @default.
• W3109739384 hasConcept C50382708 @default.
• W3109739384 hasConcept C71924100 @default.
• W3109739384 hasConcept C90924648 @default.
• W3109739384 hasConceptScore W3109739384C126322002 @default.
• W3109739384 hasConceptScore W3109739384C126838900 @default.
• W3109739384 hasConceptScore W3109739384C143409427 @default.
• W3109739384 hasConceptScore W3109739384C144301174 @default.
• W3109739384 hasConceptScore W3109739384C2776194525 @default.
• W3109739384 hasConceptScore W3109739384C2777477808 @default.
• W3109739384 hasConceptScore W3109739384C2780886150 @default.
• W3109739384 hasConceptScore W3109739384C2989005 @default.
• W3109739384 hasConceptScore W3109739384C38180746 @default.
• W3109739384 hasConceptScore W3109739384C502942594 @default.
• W3109739384 hasConceptScore W3109739384C50382708 @default.
• W3109739384 hasConceptScore W3109739384C71924100 @default.
• W3109739384 hasConceptScore W3109739384C90924648 @default.
• W3109739384 hasFunder F4320321001 @default.
• W3109739384 hasFunder F4320324076 @default.

• next