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- W3109780334 endingPage "324" @default.
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- W3109780334 abstract "The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals.We review the drug design landscape in the scientific and patent literature to design peptidomimetic and non-peptidomimetic protease inhibitors (PIs) targeting these proteins.The X-ray crystal structures of some of these proteases, alone and in complex with various inhibitors, were crucial for the discovery of effective such compounds, some of which also showed considerable antiviral activity and are considered preclinical candidates to fight these emerging infections, which in the case of Covid-19 already provoked an unprecedented worldwide pandemic." @default.
- W3109780334 created "2020-12-07" @default.
- W3109780334 creator A5018378636 @default.
- W3109780334 creator A5036969494 @default.
- W3109780334 date "2020-12-12" @default.
- W3109780334 modified "2023-10-05" @default.
- W3109780334 title "Protease inhibitors targeting the main protease and papain-like protease of coronaviruses" @default.
- W3109780334 cites W1967407510 @default.
- W3109780334 cites W1972356153 @default.
- W3109780334 cites W2012946611 @default.
- W3109780334 cites W2019345165 @default.
- W3109780334 cites W2020896146 @default.
- W3109780334 cites W2027484375 @default.
- W3109780334 cites W2033221484 @default.
- W3109780334 cites W2034368227 @default.
- W3109780334 cites W2043767415 @default.
- W3109780334 cites W2047717104 @default.
- W3109780334 cites W2052196625 @default.
- W3109780334 cites W2064861980 @default.
- W3109780334 cites W2068087698 @default.
- W3109780334 cites W2118537722 @default.
- W3109780334 cites W2126918460 @default.
- W3109780334 cites W2127691252 @default.
- W3109780334 cites W2142337547 @default.
- W3109780334 cites W2158812536 @default.
- W3109780334 cites W2161572568 @default.
- W3109780334 cites W2298953604 @default.
- W3109780334 cites W2318325277 @default.
- W3109780334 cites W2418376386 @default.
- W3109780334 cites W2624646560 @default.
- W3109780334 cites W2769689735 @default.
- W3109780334 cites W2778062090 @default.
- W3109780334 cites W2893215226 @default.
- W3109780334 cites W2907156328 @default.
- W3109780334 cites W2947642275 @default.
- W3109780334 cites W2976752549 @default.
- W3109780334 cites W2985346127 @default.
- W3109780334 cites W3000413850 @default.
- W3109780334 cites W3003752833 @default.
- W3109780334 cites W3005775246 @default.
- W3109780334 cites W3007866917 @default.
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- W3109780334 cites W3015886046 @default.
- W3109780334 cites W3016143592 @default.
- W3109780334 cites W3016311875 @default.
- W3109780334 cites W3017868191 @default.
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- W3109780334 doi "https://doi.org/10.1080/13543776.2021.1857726" @default.
- W3109780334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33246378" @default.
- W3109780334 hasPublicationYear "2020" @default.
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