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- W3109784498 abstract "Abstract Small interfering RNA (siRNA)-based RNA interference has emerged as a promising therapeutic strategy for the treatment of a wide range of incurable diseases. However, the safe and effective delivery of siRNA therapeutics into the interior of target cells remains challenging. Here, we disclosed novel amphiphilic peptide dendrimers (AmPDs) that composed of hydrophobic two lipid-like alkyl chains and hydrophilic poly(lysine) dendrons with different generations (2C 18 -KK 2 and 2C 18 -KK 2 K 4 ) as nanovehicles for siRNA delivery. These AmPDs are able to self-assemble into supramolecular nanoassemblies that are capable of entrapping siRNA molecules into nanoparticles to protect siRNA from enzymatic degradation and promote efficient intracellular uptake without evident toxicity. Interestingly, by virtue of the optimal balance of hydrophobic lipid-like entity and hydrophilic poly(lysine) dendron generations, AmPD 2C 18 -KK 2 K 4 bearing bigger hydrophilic dendron can package siRNA to form stable, but more ready to disassemble complexes, thereby resulting in more efficient siRNA releasing and better gene silencing effect in comparison with AmPD 2C 18 -KK 2 bearing smaller dendron. Additional studies confirmed that 2C 18 -KK 2 K 4 can capitalize on the advantages of lipid and peptide dendrimer vectors for effective siRNA delivery. Collectively, our AmPD-based nanocarriers indeed represent a safe and effective siRNA delivery system. Our findings also provide a new perspective on the modulation of self-assembly amphiphilic peptide dendrimers for the functional and adaptive delivery of siRNA therapeutics." @default.
- W3109784498 created "2020-12-07" @default.
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- W3109784498 date "2020-11-21" @default.
- W3109784498 modified "2023-09-23" @default.
- W3109784498 title "Amphiphilic peptide dendrimer-based nanovehicles for safe and effective siRNA delivery" @default.
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- W3109784498 doi "https://doi.org/10.1007/s41048-020-00120-z" @default.
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