FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109793670> ?p ?o ?g. }

• W3109793670 endingPage "762" @default.
• W3109793670 startingPage "751" @default.
• W3109793670 abstract "The plasma proteome is the ultimate target for biomarker discovery. It stores an endless amount of information on the pathophysiological status of a living organism, which is, however, still difficult to comprehensively access. The high complexity of the plasma proteome can be addressed by either a system-wide and unbiased tool such as mass spectrometry (LC-MS/MS) or a highly sensitive targeted immunoassay such as the proximity extension assay (PEA). To address relevant differences and important shared characteristics, we tested the performance of LC-MS/MS in the data-dependent and data-independent acquisition modes and Olink PEA to measure circulating plasma proteins in 173 human plasma samples from a Southern German population-based cohort. We demonstrated the measurement of more than 300 proteins with both LC-MS/MS approaches applied, mainly including high-abundance plasma proteins. By the use of the PEA technology, we measured 728 plasma proteins, covering a broad dynamic range with high sensitivity down to pg/mL concentrations. Then, we quantified 35 overlapping proteins with all three analytical platforms, verifying the reproducibility of data distributions, measurement correlation, and gender-based differential expression. Our work highlights the limitations and the advantages of both targeted and untargeted approaches and proves their complementary strengths. We demonstrated a significant gain in proteome coverage depth and subsequent biological insight by a combination of platforms-a promising approach for future biomarker and mechanistic studies." @default.
• W3109793670 created "2020-12-07" @default.
• W3109793670 creator A5005427451 @default.
• W3109793670 creator A5005466117 @default.
• W3109793670 creator A5014477506 @default.
• W3109793670 creator A5025063238 @default.
• W3109793670 creator A5025441654 @default.
• W3109793670 creator A5025642544 @default.
• W3109793670 creator A5036794240 @default.
• W3109793670 date "2020-11-30" @default.
• W3109793670 modified "2023-10-17" @default.
• W3109793670 title "Multiplatform Approach for Plasma Proteomics: Complementarity of Olink Proximity Extension Assay Technology to Mass Spectrometry-Based Protein Profiling" @default.
• W3109793670 cites W2010084870 @default.
• W3109793670 cites W2011846108 @default.
• W3109793670 cites W2013743510 @default.
• W3109793670 cites W2019196704 @default.
• W3109793670 cites W2021828126 @default.
• W3109793670 cites W2053943711 @default.
• W3109793670 cites W2060427373 @default.
• W3109793670 cites W2094559890 @default.
• W3109793670 cites W2117159668 @default.
• W3109793670 cites W2123442465 @default.
• W3109793670 cites W2270987730 @default.
• W3109793670 cites W2302629258 @default.
• W3109793670 cites W2462038997 @default.
• W3109793670 cites W2511683610 @default.
• W3109793670 cites W2516732830 @default.
• W3109793670 cites W2520903792 @default.
• W3109793670 cites W2550449684 @default.
• W3109793670 cites W2563604932 @default.
• W3109793670 cites W2566116513 @default.
• W3109793670 cites W2590064181 @default.
• W3109793670 cites W2602123787 @default.
• W3109793670 cites W2608535836 @default.
• W3109793670 cites W2612563398 @default.
• W3109793670 cites W2759363431 @default.
• W3109793670 cites W2802856655 @default.
• W3109793670 cites W2805712258 @default.
• W3109793670 cites W2808428344 @default.
• W3109793670 cites W2885469779 @default.
• W3109793670 cites W2893919806 @default.
• W3109793670 cites W2902954395 @default.
• W3109793670 cites W2907303285 @default.
• W3109793670 cites W2919811956 @default.
• W3109793670 cites W2931155919 @default.
• W3109793670 cites W2953050063 @default.
• W3109793670 cites W2973799453 @default.
• W3109793670 cites W2979236711 @default.
• W3109793670 cites W2981814305 @default.
• W3109793670 cites W2988339276 @default.
• W3109793670 cites W3017096941 @default.
• W3109793670 cites W3025465078 @default.
• W3109793670 doi "https://doi.org/10.1021/acs.jproteome.0c00641" @default.
• W3109793670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33253581" @default.
• W3109793670 hasPublicationYear "2020" @default.
• W3109793670 type Work @default.
• W3109793670 sameAs 3109793670 @default.
• W3109793670 citedByCount "72" @default.
• W3109793670 countsByYear W31097936702021 @default.
• W3109793670 countsByYear W31097936702022 @default.
• W3109793670 countsByYear W31097936702023 @default.
• W3109793670 crossrefType "journal-article" @default.
• W3109793670 hasAuthorship W3109793670A5005427451 @default.
• W3109793670 hasAuthorship W3109793670A5005466117 @default.
• W3109793670 hasAuthorship W3109793670A5014477506 @default.
• W3109793670 hasAuthorship W3109793670A5025063238 @default.
• W3109793670 hasAuthorship W3109793670A5025441654 @default.
• W3109793670 hasAuthorship W3109793670A5025642544 @default.
• W3109793670 hasAuthorship W3109793670A5036794240 @default.
• W3109793670 hasBestOaLocation W31097936702 @default.
• W3109793670 hasConcept C104317684 @default.
• W3109793670 hasConcept C111919701 @default.
• W3109793670 hasConcept C162356407 @default.
• W3109793670 hasConcept C185592680 @default.
• W3109793670 hasConcept C187191949 @default.
• W3109793670 hasConcept C41008148 @default.
• W3109793670 hasConcept C43617362 @default.
• W3109793670 hasConcept C46111723 @default.
• W3109793670 hasConcept C55493867 @default.
• W3109793670 hasConcept C70721500 @default.
• W3109793670 hasConcept C86803240 @default.
• W3109793670 hasConceptScore W3109793670C104317684 @default.
• W3109793670 hasConceptScore W3109793670C111919701 @default.
• W3109793670 hasConceptScore W3109793670C162356407 @default.
• W3109793670 hasConceptScore W3109793670C185592680 @default.
• W3109793670 hasConceptScore W3109793670C187191949 @default.
• W3109793670 hasConceptScore W3109793670C41008148 @default.
• W3109793670 hasConceptScore W3109793670C43617362 @default.
• W3109793670 hasConceptScore W3109793670C46111723 @default.
• W3109793670 hasConceptScore W3109793670C55493867 @default.
• W3109793670 hasConceptScore W3109793670C70721500 @default.
• W3109793670 hasConceptScore W3109793670C86803240 @default.
• W3109793670 hasFunder F4320321114 @default.
• W3109793670 hasIssue "1" @default.
• W3109793670 hasLocation W31097936701 @default.
• W3109793670 hasLocation W31097936702 @default.
• W3109793670 hasOpenAccess W3109793670 @default.
• W3109793670 hasPrimaryLocation W31097936701 @default.

• next