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- W3109832015 abstract "Background Mucosal healing (MH) is the key aim of the treat-to-target strategy for patients with Crohn’s disease (CD). The efficacy of infliximab on MH in different ileocolonic segments is unclear. The aim of this study was to investigate endoscopic MH in different ileocolonic segments in patients with CD who received infliximab treatment. Methods A retrospective, single-center study was performed in patients with active ileocolonic CD between January 2012 and December 2018. All patients underwent IFX treatment for at least 30 weeks. The MH of five ileocolonic segments was assessed by the Simple Endoscopic Score for CD (SES-CD) at baseline, week 14 and week 30. The SES-CD scores were analyzed by a mixed-effects model after the confounding factors were corrected. Results A total of 101 eligible patients were included. The baseline endoscopic severity was similar across segments. At week 30, the greatest changes in SES-CD ulcer size and ulcerated surface were -94.29% and -94.32% both in the transverse colon (P Conclusions Ileocolonic segments in Crohn’s disease presented different endoscopic MH during IFX treatment. The transverse colon showed the highest MH rate, whereas the right colon had poor improvement in stenosis even underwent long-term IFX therapy." @default.
- W3109832015 created "2020-12-07" @default.
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- W3109832015 date "2020-11-01" @default.
- W3109832015 modified "2023-10-16" @default.
- W3109832015 title "IDDF2020-ABS-0190 Efficacy of infliximab treatment on the mucosal healing of different intestinal segments in patients with ileocolonic Crohn’s disease" @default.
- W3109832015 doi "https://doi.org/10.1136/gutjnl-2020-iddf.113" @default.
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