Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109876847> ?p ?o ?g. }
- W3109876847 endingPage "9117" @default.
- W3109876847 startingPage "9117" @default.
- W3109876847 abstract "West Nile virus (WNV), like the dengue virus (DENV) and yellow fever virus (YFV), are major arboviruses belonging to the Flavivirus genus. WNV is emerging or endemic in many countries around the world, affecting humans and other vertebrates. Since 1999, it has been considered to be a major public and veterinary health problem, causing diverse pathologies, ranging from a mild febrile state to severe neurological damage and death. WNV is transmitted in a bird–mosquito–bird cycle, and can occasionally infect humans and horses, both highly susceptible to the virus but considered dead-end hosts. Many studies have investigated the molecular determinants of WNV virulence, mainly with the ultimate objective of guiding vaccine development. Several vaccines are used in horses in different parts of the world, but there are no licensed WNV vaccines for humans, suggesting the need for greater understanding of the molecular determinants of virulence and antigenicity in different hosts. Owing to technical and economic considerations, WNV virulence factors have essentially been studied in rodent models, and the results cannot always be transported to mosquito vectors or to avian hosts. In this review, the known molecular determinants of WNV virulence, according to invertebrate (mosquitoes) or vertebrate hosts (mammalian and avian), are presented and discussed. This overview will highlight the differences and similarities found between WNV hosts and models, to provide a foundation for the prediction and anticipation of WNV re-emergence and its risk of global spread." @default.
- W3109876847 created "2020-12-07" @default.
- W3109876847 creator A5018028566 @default.
- W3109876847 creator A5026659848 @default.
- W3109876847 creator A5044288126 @default.
- W3109876847 creator A5064442184 @default.
- W3109876847 creator A5064758387 @default.
- W3109876847 creator A5068835636 @default.
- W3109876847 date "2020-11-30" @default.
- W3109876847 modified "2023-10-05" @default.
- W3109876847 title "Molecular Determinants of West Nile Virus Virulence and Pathogenesis in Vertebrate and Invertebrate Hosts" @default.
- W3109876847 cites W1278012999 @default.
- W3109876847 cites W1572786643 @default.
- W3109876847 cites W1826433850 @default.
- W3109876847 cites W1865324159 @default.
- W3109876847 cites W1893064134 @default.
- W3109876847 cites W1912162740 @default.
- W3109876847 cites W1944716329 @default.
- W3109876847 cites W1966277979 @default.
- W3109876847 cites W1970954959 @default.
- W3109876847 cites W1972387878 @default.
- W3109876847 cites W1972431524 @default.
- W3109876847 cites W1972545077 @default.
- W3109876847 cites W1973123733 @default.
- W3109876847 cites W1973140553 @default.
- W3109876847 cites W1976308168 @default.
- W3109876847 cites W1978952710 @default.
- W3109876847 cites W1979820507 @default.
- W3109876847 cites W1980138800 @default.
- W3109876847 cites W1980523796 @default.
- W3109876847 cites W1980560678 @default.
- W3109876847 cites W1981822821 @default.
- W3109876847 cites W1988402786 @default.
- W3109876847 cites W1989392875 @default.
- W3109876847 cites W1990135737 @default.
- W3109876847 cites W1990458022 @default.
- W3109876847 cites W1992085877 @default.
- W3109876847 cites W1992847902 @default.
- W3109876847 cites W1998293016 @default.
- W3109876847 cites W1998748437 @default.
- W3109876847 cites W1999927176 @default.
- W3109876847 cites W2001574592 @default.
- W3109876847 cites W2001717973 @default.
- W3109876847 cites W2003574450 @default.
- W3109876847 cites W2004680936 @default.
- W3109876847 cites W2005578471 @default.
- W3109876847 cites W2008401094 @default.
- W3109876847 cites W2008437904 @default.
- W3109876847 cites W2008560530 @default.
- W3109876847 cites W2011074917 @default.
- W3109876847 cites W2011123717 @default.
- W3109876847 cites W2012415080 @default.
- W3109876847 cites W2012906379 @default.
- W3109876847 cites W2013820517 @default.
- W3109876847 cites W2015117195 @default.
- W3109876847 cites W2016563525 @default.
- W3109876847 cites W2016565011 @default.
- W3109876847 cites W2018071918 @default.
- W3109876847 cites W2018082743 @default.
- W3109876847 cites W2018127052 @default.
- W3109876847 cites W2018259162 @default.
- W3109876847 cites W2019643807 @default.
- W3109876847 cites W2020934094 @default.
- W3109876847 cites W2021921065 @default.
- W3109876847 cites W2028190215 @default.
- W3109876847 cites W2028198504 @default.
- W3109876847 cites W2030996826 @default.
- W3109876847 cites W2033317222 @default.
- W3109876847 cites W2033573754 @default.
- W3109876847 cites W2036119279 @default.
- W3109876847 cites W2039869672 @default.
- W3109876847 cites W2040383994 @default.
- W3109876847 cites W2040786554 @default.
- W3109876847 cites W2042795084 @default.
- W3109876847 cites W2043969835 @default.
- W3109876847 cites W2044984156 @default.
- W3109876847 cites W2047267586 @default.
- W3109876847 cites W2048727774 @default.
- W3109876847 cites W2049285992 @default.
- W3109876847 cites W2054371869 @default.
- W3109876847 cites W2054676351 @default.
- W3109876847 cites W2055972388 @default.
- W3109876847 cites W2057093156 @default.
- W3109876847 cites W2057566607 @default.
- W3109876847 cites W2057653606 @default.
- W3109876847 cites W2057829396 @default.
- W3109876847 cites W2058658401 @default.
- W3109876847 cites W2058984547 @default.
- W3109876847 cites W2060148547 @default.
- W3109876847 cites W2060889783 @default.
- W3109876847 cites W2065347535 @default.
- W3109876847 cites W2065843293 @default.
- W3109876847 cites W2066006652 @default.
- W3109876847 cites W2067668336 @default.
- W3109876847 cites W2069066673 @default.
- W3109876847 cites W2074799141 @default.
- W3109876847 cites W2075235747 @default.
- W3109876847 cites W2075883777 @default.