Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109884052> ?p ?o ?g. }
- W3109884052 endingPage "9270" @default.
- W3109884052 startingPage "9270" @default.
- W3109884052 abstract "Additive manufacturing is a key technology required to realize the production of a personalized bone substitute that exactly meets a patient’s need and fills a patient-specific bone defect. Additive manufacturing can optimize the inner architecture of the scaffold for osteoconduction, allowing fast and reliable defect bridging by promoting rapid growth of new bone tissue into the scaffold. The role of scaffold microporosity/nanoarchitecture in osteoconduction remains elusive. To elucidate this relationship, we produced lithography-based osteoconductive scaffolds from tricalcium phosphate (TCP) with identical macro- and microarchitecture, but varied their nanoarchitecture/microporosity by ranging maximum sintering temperatures from 1000 °C to 1200 °C. After characterization of the different scaffolds’ microporosity, compression strength, and nanoarchitecture, we performed in vivo studies that showed that ingrowth of bone as an indicator of osteoconduction significantly decreased with decreasing microporosity. Moreover, at the 1200 °C peak sinter temperature and lowest microporosity, osteoclastic degradation of the material was inhibited. Thus, even for wide-open porous TCP-based scaffolds, a high degree of microporosity appears to be essential for optimal osteoconduction and creeping substitution, which can prevent non-unions, the major complication during bone regeneration procedures." @default.
- W3109884052 created "2020-12-07" @default.
- W3109884052 creator A5014029087 @default.
- W3109884052 creator A5032554640 @default.
- W3109884052 creator A5057139834 @default.
- W3109884052 creator A5068295456 @default.
- W3109884052 creator A5085701003 @default.
- W3109884052 date "2020-12-04" @default.
- W3109884052 modified "2023-09-26" @default.
- W3109884052 title "Microporosities in 3D-Printed Tricalcium-Phosphate-Based Bone Substitutes Enhance Osteoconduction and Affect Osteoclastic Resorption" @default.
- W3109884052 cites W1531447386 @default.
- W3109884052 cites W1574277043 @default.
- W3109884052 cites W1915531950 @default.
- W3109884052 cites W1966532575 @default.
- W3109884052 cites W1976212754 @default.
- W3109884052 cites W1992610301 @default.
- W3109884052 cites W2005720246 @default.
- W3109884052 cites W2006794541 @default.
- W3109884052 cites W2007453290 @default.
- W3109884052 cites W2019091109 @default.
- W3109884052 cites W2023468805 @default.
- W3109884052 cites W2027086864 @default.
- W3109884052 cites W2039538032 @default.
- W3109884052 cites W2046685458 @default.
- W3109884052 cites W2055550070 @default.
- W3109884052 cites W2059905814 @default.
- W3109884052 cites W2066488971 @default.
- W3109884052 cites W2077230011 @default.
- W3109884052 cites W2078126231 @default.
- W3109884052 cites W2086194573 @default.
- W3109884052 cites W2088520660 @default.
- W3109884052 cites W2091609802 @default.
- W3109884052 cites W2094245735 @default.
- W3109884052 cites W2102532187 @default.
- W3109884052 cites W2124195334 @default.
- W3109884052 cites W2125923022 @default.
- W3109884052 cites W2146732527 @default.
- W3109884052 cites W2155290928 @default.
- W3109884052 cites W2169727595 @default.
- W3109884052 cites W2265139392 @default.
- W3109884052 cites W2514979671 @default.
- W3109884052 cites W2535753485 @default.
- W3109884052 cites W2603374379 @default.
- W3109884052 cites W2624273936 @default.
- W3109884052 cites W262912863 @default.
- W3109884052 cites W2793893149 @default.
- W3109884052 cites W2809639588 @default.
- W3109884052 cites W2811493528 @default.
- W3109884052 cites W2889592653 @default.
- W3109884052 cites W2900099262 @default.
- W3109884052 cites W2901334660 @default.
- W3109884052 cites W2936716985 @default.
- W3109884052 cites W2938342554 @default.
- W3109884052 cites W2966394743 @default.
- W3109884052 cites W4236142584 @default.
- W3109884052 cites W4292330637 @default.
- W3109884052 doi "https://doi.org/10.3390/ijms21239270" @default.
- W3109884052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7731226" @default.
- W3109884052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33291724" @default.
- W3109884052 hasPublicationYear "2020" @default.
- W3109884052 type Work @default.
- W3109884052 sameAs 3109884052 @default.
- W3109884052 citedByCount "13" @default.
- W3109884052 countsByYear W31098840522021 @default.
- W3109884052 countsByYear W31098840522022 @default.
- W3109884052 countsByYear W31098840522023 @default.
- W3109884052 crossrefType "journal-article" @default.
- W3109884052 hasAuthorship W3109884052A5014029087 @default.
- W3109884052 hasAuthorship W3109884052A5032554640 @default.
- W3109884052 hasAuthorship W3109884052A5057139834 @default.
- W3109884052 hasAuthorship W3109884052A5068295456 @default.
- W3109884052 hasAuthorship W3109884052A5085701003 @default.
- W3109884052 hasBestOaLocation W31098840521 @default.
- W3109884052 hasConcept C127413603 @default.
- W3109884052 hasConcept C136229726 @default.
- W3109884052 hasConcept C142724271 @default.
- W3109884052 hasConcept C146562846 @default.
- W3109884052 hasConcept C159985019 @default.
- W3109884052 hasConcept C192562407 @default.
- W3109884052 hasConcept C2777581544 @default.
- W3109884052 hasConcept C42360764 @default.
- W3109884052 hasConcept C54355233 @default.
- W3109884052 hasConcept C6648577 @default.
- W3109884052 hasConcept C673006 @default.
- W3109884052 hasConcept C71924100 @default.
- W3109884052 hasConcept C86803240 @default.
- W3109884052 hasConcept C89429830 @default.
- W3109884052 hasConceptScore W3109884052C127413603 @default.
- W3109884052 hasConceptScore W3109884052C136229726 @default.
- W3109884052 hasConceptScore W3109884052C142724271 @default.
- W3109884052 hasConceptScore W3109884052C146562846 @default.
- W3109884052 hasConceptScore W3109884052C159985019 @default.
- W3109884052 hasConceptScore W3109884052C192562407 @default.
- W3109884052 hasConceptScore W3109884052C2777581544 @default.
- W3109884052 hasConceptScore W3109884052C42360764 @default.
- W3109884052 hasConceptScore W3109884052C54355233 @default.
- W3109884052 hasConceptScore W3109884052C6648577 @default.
- W3109884052 hasConceptScore W3109884052C673006 @default.