Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109899469> ?p ?o ?g. }
- W3109899469 endingPage "5724" @default.
- W3109899469 startingPage "5724" @default.
- W3109899469 abstract "In our previous study, temporin-GHaR (GHaR) showed potent antimicrobial activity with strong hemolytic toxicity. To overcome its weakness, we designed GHaR6R, GHaR7R, GHaR8R, GHaR9R, and GHaR9W by changing the number of positive charges and the hydrophobic surface of GHaR. With the exception of GHaR7R, the hemolytic toxicity of the derived peptides had been reduced, and the antimicrobial activities remained close to the parent peptide (except for GHaR9R). GHaR6R, GHaR7R, GHaR8R, and GHaR9W exhibited a great bactericidal effect on Streptococcus mutans (S. mutans), which is one of the main pathogens causing dental caries. According to the membrane permeation and scanning electron microscope (SEM) analysis, these derived peptides targeted to the cell membranes of planktonic bacteria, contributing to the disruption of the membrane integrity and leakage of the intracellular contents. Moreover, they inhibited the formation of biofilms and eradicated the mature biofilms of S. mutans. Compared with GHaR7R, the derived peptides showed less cytotoxicity to human oral epithelial cells (HOECs). The derived peptides are expected to be the molecular templates for designing antibacterial agents to prevent dental caries." @default.
- W3109899469 created "2020-12-07" @default.
- W3109899469 creator A5003534135 @default.
- W3109899469 creator A5014813712 @default.
- W3109899469 creator A5035375969 @default.
- W3109899469 creator A5044518121 @default.
- W3109899469 creator A5053193274 @default.
- W3109899469 creator A5062079284 @default.
- W3109899469 creator A5063699906 @default.
- W3109899469 creator A5066637721 @default.
- W3109899469 creator A5067510720 @default.
- W3109899469 creator A5088697197 @default.
- W3109899469 date "2020-12-04" @default.
- W3109899469 modified "2023-09-28" @default.
- W3109899469 title "Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis" @default.
- W3109899469 cites W1911323177 @default.
- W3109899469 cites W1963776097 @default.
- W3109899469 cites W1967892852 @default.
- W3109899469 cites W1989642335 @default.
- W3109899469 cites W2009106357 @default.
- W3109899469 cites W2009123582 @default.
- W3109899469 cites W2015436722 @default.
- W3109899469 cites W2020790969 @default.
- W3109899469 cites W2024650759 @default.
- W3109899469 cites W2031701155 @default.
- W3109899469 cites W2054537853 @default.
- W3109899469 cites W2054602599 @default.
- W3109899469 cites W2068894345 @default.
- W3109899469 cites W2080936059 @default.
- W3109899469 cites W2084465048 @default.
- W3109899469 cites W2084699782 @default.
- W3109899469 cites W2085132331 @default.
- W3109899469 cites W2087125825 @default.
- W3109899469 cites W2128301757 @default.
- W3109899469 cites W2129744517 @default.
- W3109899469 cites W2152323052 @default.
- W3109899469 cites W2162149255 @default.
- W3109899469 cites W2170912840 @default.
- W3109899469 cites W2413638618 @default.
- W3109899469 cites W2478960475 @default.
- W3109899469 cites W2592149021 @default.
- W3109899469 cites W2594950311 @default.
- W3109899469 cites W2600121819 @default.
- W3109899469 cites W2619415615 @default.
- W3109899469 cites W2755856023 @default.
- W3109899469 cites W2766221882 @default.
- W3109899469 cites W2782709019 @default.
- W3109899469 cites W2793041245 @default.
- W3109899469 cites W2794138542 @default.
- W3109899469 cites W2801183472 @default.
- W3109899469 cites W2803476736 @default.
- W3109899469 cites W2903520866 @default.
- W3109899469 cites W2923736658 @default.
- W3109899469 cites W2983664268 @default.
- W3109899469 cites W2994998198 @default.
- W3109899469 cites W3032084754 @default.
- W3109899469 cites W4249723987 @default.
- W3109899469 doi "https://doi.org/10.3390/molecules25235724" @default.
- W3109899469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7730238" @default.
- W3109899469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33291521" @default.
- W3109899469 hasPublicationYear "2020" @default.
- W3109899469 type Work @default.
- W3109899469 sameAs 3109899469 @default.
- W3109899469 citedByCount "19" @default.
- W3109899469 countsByYear W31098994692021 @default.
- W3109899469 countsByYear W31098994692022 @default.
- W3109899469 countsByYear W31098994692023 @default.
- W3109899469 crossrefType "journal-article" @default.
- W3109899469 hasAuthorship W3109899469A5003534135 @default.
- W3109899469 hasAuthorship W3109899469A5014813712 @default.
- W3109899469 hasAuthorship W3109899469A5035375969 @default.
- W3109899469 hasAuthorship W3109899469A5044518121 @default.
- W3109899469 hasAuthorship W3109899469A5053193274 @default.
- W3109899469 hasAuthorship W3109899469A5062079284 @default.
- W3109899469 hasAuthorship W3109899469A5063699906 @default.
- W3109899469 hasAuthorship W3109899469A5066637721 @default.
- W3109899469 hasAuthorship W3109899469A5067510720 @default.
- W3109899469 hasAuthorship W3109899469A5088697197 @default.
- W3109899469 hasBestOaLocation W31098994691 @default.
- W3109899469 hasConcept C185592680 @default.
- W3109899469 hasConcept C203014093 @default.
- W3109899469 hasConcept C2778430296 @default.
- W3109899469 hasConcept C2779281246 @default.
- W3109899469 hasConcept C2779902561 @default.
- W3109899469 hasConcept C4937899 @default.
- W3109899469 hasConcept C523546767 @default.
- W3109899469 hasConcept C540938839 @default.
- W3109899469 hasConcept C54355233 @default.
- W3109899469 hasConcept C55493867 @default.
- W3109899469 hasConcept C58123911 @default.
- W3109899469 hasConcept C79879829 @default.
- W3109899469 hasConcept C86803240 @default.
- W3109899469 hasConcept C89423630 @default.
- W3109899469 hasConceptScore W3109899469C185592680 @default.
- W3109899469 hasConceptScore W3109899469C203014093 @default.
- W3109899469 hasConceptScore W3109899469C2778430296 @default.
- W3109899469 hasConceptScore W3109899469C2779281246 @default.
- W3109899469 hasConceptScore W3109899469C2779902561 @default.