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- W3109904006 abstract "Abstract Learning to anticipate potentially dangerous contexts is an adaptive behavioral response to coping with stressors. An animal’s stress coping style (e.g. proactive-reactive axis) is known to influence how it encodes salient events. However, the neural and molecular mechanisms underlying these stress coping style differences in learning are unknown. Further, while a number of neuroplasticity-related genes have been associated with alternative stress coping styles, it is unclear if these genes may bias the development of conditioned behavioral responses to stressful stimuli, and if so, which brain regions are involved. Here, we trained adult zebrafish to associate a naturally aversive olfactory cue with a given context. Next, we investigated if expression of two neural plasticity and neurotransmission-related genes ( npas4a and gabbr1a ) were associated with the contextual fear conditioning differences between proactive and reactive stress coping styles. Reactive zebrafish developed a stronger conditioned fear response and showed significantly higher npas4a expression in the medial and lateral zones of the dorsal telencephalon (Dm, Dl), and the supracommissural nucleus of the ventral telencephalon (Vs). Our findings suggest that the magnitude of expression of activity-dependent genes like npas4a may be differentially expressed across several interconnected forebrain regions in response to fearful stimuli and promote biases in fear learning among different stress coping styles." @default.
- W3109904006 created "2020-12-07" @default.
- W3109904006 creator A5040786107 @default.
- W3109904006 creator A5042848781 @default.
- W3109904006 date "2020-11-25" @default.
- W3109904006 modified "2023-09-23" @default.
- W3109904006 title "Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning" @default.
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- W3109904006 doi "https://doi.org/10.1101/2020.11.24.396887" @default.
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