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• W3109908052 abstract "Event Abstract Back to Event Multivesicular bodies and their relationship with mitochondria in the rodent somatosensory cortex Marta Turégano-López1*, Andrea Santuy1*, Javier DeFelipe1, 2* and Angel Merchan-Perez1, 3 1 Universidad Politécnica de Madrid, Centro de Tecnología Biomédica, Spain 2 Instituto Cajal, Consejo Superior de Investigaciones Científicas, Spain 3 Universidad Politécnica de Madrid, Departamento de Arquitectura y Tecnología de sistemas Informáticos, Spain Multivesicular bodies (MVBs) are spherical organelles that are surrounded by a single membrane and contain small vesicles in their lumen. They are involved in degradation of cell components as an intermediary of the endosomal pathway. They also recycle cell components and are able to insert receptors in membranes that are far away from the neural soma. MVBs can fuse to plasma membrane and release exosomes that are essential for cell-to-cell communication. It has recently been described that MVBs store and transport damaged cargo from mitochondria and break it down by fusing with lysosomes. MVBs are also known to accumulate the protein aggregates that are involved in pathological conditions like Alzheimer’s disease and Parkinson disease. We used three dimensional electron microscopy with combined focused ion beam milling and scanning electron microscopy (FIB/SEM) to reconstruct MVBs in the rodent somatosensory cortex. We obtained ten stacks of serial sections from the neuropil of layer III. Using specifically developed software (Espina), we segmented and three-dimensionally reconstructed 678 MVBs. This revealed differences in their size and content (dark or clear vesicles). Some of them (7%) contained dark electron-dense laminar material in addition to the usual vesicles. We then classified MVBs based on their location. Our preliminary results indicate that MVBs located in dendrites outnumber those located on axons in approximately a 3:1 proportion. We also determined whether MVBs were related to other subcellular organelles, with special attention to mitochondria. We found that 19% were in contact with mitochondria. These MVBs are probably incorporating the damaged protein cargo contained in mitochondrial-derived vesicles, thereby acting as a defense mechanism that helps maintain normal mitochondrial function. The quantitative method that we have developed here will help determine the possible alterations of the endosomal pathway in pathological conditions. Keywords: Multivesicular Bodies, Endosomal pathway, Mitochondria, Cerebral Cortex, Electron microscopy Conference: B·DEBATE | A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing (Workshop), Barcelona, Spain, 29 Apr - 30 Apr, 2015. Presentation Type: Poster Presentation Topic: SESSION 1: Cortical Function and Computations Citation: Turégano-López M, Santuy A, DeFelipe J and Merchan-Perez A (2015). Multivesicular bodies and their relationship with mitochondria in the rodent somatosensory cortex. Front. Syst. Neurosci. Conference Abstract: B·DEBATE | A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing (Workshop). doi: 10.3389/conf.fnsys.2015.06.00005 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 20 Apr 2015; Published Online: 06 May 2015. * Correspondence: Ms. Marta Turégano-López, Universidad Politécnica de Madrid, Centro de Tecnología Biomédica, Pozuelo de Alarcón, Madrid, Spain, marta.turegano@estudiante.uam.es Ms. Andrea Santuy, Universidad Politécnica de Madrid, Centro de Tecnología Biomédica, Pozuelo de Alarcón, Madrid, Spain, andrea.santuy@ctb.upm.es Dr. Javier DeFelipe, Universidad Politécnica de Madrid, Centro de Tecnología Biomédica, Pozuelo de Alarcón, Madrid, Spain, defelipe@cajal.csic.es Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Marta Turégano-López Andrea Santuy Javier DeFelipe Angel Merchan-Perez Google Marta Turégano-López Andrea Santuy Javier DeFelipe Angel Merchan-Perez Google Scholar Marta Turégano-López Andrea Santuy Javier DeFelipe Angel Merchan-Perez PubMed Marta Turégano-López Andrea Santuy Javier DeFelipe Angel Merchan-Perez Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W3109908052 title "Multivesicular bodies and their relationship with mitochondria in the rodent somatosensory cortex" @default.
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