FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109911795> ?p ?o ?g. }

• W3109911795 endingPage "5335" @default.
• W3109911795 startingPage "5323" @default.
• W3109911795 abstract "Microgels are emerging as an outstanding platform for tissue regeneration because they overcome issues associated with conventional bulk/macroscopic hydrogels such as limited cell–cell contact and cell communication and low diffusion rates. Owing to the enhanced mass transfer and injectability via a minimally invasive procedure, these microgels are becoming a promising approach for bone regeneration applications. Nevertheless, there still remains a huge gap between the understanding of how the hydrogel matrix composition can influence cell response and overall tissue formation when switching from bulk formats to microgel format, which is often neglected or rarely studied. Here, we fabricated polyethylene glycol-based microgels and bulk hydrogels incorporating gelatin and hyaluronic acid (HA), either individually or together, and assessed the impact of both hydrogel composition and format upon the osteogenic differentiation of encapsulated human bone marrow-derived mesenchymal stem cells (hBMSCs). Osteogenesis was significantly greater in microgels than bulk hydrogels for both gelatin alone (Gel) and gelatin HA composite (Gel:HA) hydrogels, as determined by the expression of Runt-related transcription factor (Runx2) and alkaline phosphatase (ALP) genes and mineral deposition. Interestingly, Gel and Gel:HA hydrogels behaved differently between bulk and microgel format. In bulk format, overall osteogenic outcomes were better in Gel:HA hydrogels, but in microgel format, while the level of osteogenic gene expression was equivalent between both compositions, the degree of mineralization was reduced in Gel:HA microgels. Investigation into the affinity of hydroxyapatite for the different matrix compositions indicated that the decreased mineralization of Gel:HA microgels was likely due to a low affinity of hydroxyapatite to bind to HA and support mineral deposition, which has a greater impact on microgels than bulk hydrogels. Together, these findings suggest that both hydrogel composition and format can determine the success of tissue formation and that there is a complex interplay of these two factors on both cell behavior and matrix deposition. This has important implications for tissue engineering, showing that hydrogel composition and geometry must be evaluated together when optimizing conditions for cell differentiation and tissue formation." @default.
• W3109911795 created "2020-12-07" @default.
• W3109911795 creator A5003512608 @default.
• W3109911795 creator A5013278579 @default.
• W3109911795 creator A5046202195 @default.
• W3109911795 creator A5046968551 @default.
• W3109911795 creator A5079826385 @default.
• W3109911795 date "2020-11-25" @default.
• W3109911795 modified "2023-10-18" @default.
• W3109911795 title "Interplay of Hydrogel Composition and Geometry on Human Mesenchymal Stem Cell Osteogenesis" @default.
• W3109911795 cites W1032770180 @default.
• W3109911795 cites W1480757763 @default.
• W3109911795 cites W1968138400 @default.
• W3109911795 cites W1969212449 @default.
• W3109911795 cites W1970824735 @default.
• W3109911795 cites W1974638778 @default.
• W3109911795 cites W1976114333 @default.
• W3109911795 cites W1984678678 @default.
• W3109911795 cites W1993680967 @default.
• W3109911795 cites W2004231871 @default.
• W3109911795 cites W2004982583 @default.
• W3109911795 cites W2007055960 @default.
• W3109911795 cites W2008808707 @default.
• W3109911795 cites W2014677040 @default.
• W3109911795 cites W2016990867 @default.
• W3109911795 cites W2024621576 @default.
• W3109911795 cites W2028421282 @default.
• W3109911795 cites W2041561034 @default.
• W3109911795 cites W2052647448 @default.
• W3109911795 cites W2053288021 @default.
• W3109911795 cites W2053865047 @default.
• W3109911795 cites W2055037957 @default.
• W3109911795 cites W2070711459 @default.
• W3109911795 cites W2077713404 @default.
• W3109911795 cites W2085039514 @default.
• W3109911795 cites W2090100338 @default.
• W3109911795 cites W2101602694 @default.
• W3109911795 cites W2108465565 @default.
• W3109911795 cites W2111469399 @default.
• W3109911795 cites W2114239412 @default.
• W3109911795 cites W2118687720 @default.
• W3109911795 cites W2134208433 @default.
• W3109911795 cites W2146451765 @default.
• W3109911795 cites W2153320120 @default.
• W3109911795 cites W2160890493 @default.
• W3109911795 cites W2164814162 @default.
• W3109911795 cites W2182832651 @default.
• W3109911795 cites W2285676653 @default.
• W3109911795 cites W2327117475 @default.
• W3109911795 cites W2340512898 @default.
• W3109911795 cites W2536336801 @default.
• W3109911795 cites W2555570490 @default.
• W3109911795 cites W2578851460 @default.
• W3109911795 cites W2582939800 @default.
• W3109911795 cites W2590749343 @default.
• W3109911795 cites W2620435339 @default.
• W3109911795 cites W2623981860 @default.
• W3109911795 cites W2763024219 @default.
• W3109911795 cites W2793557861 @default.
• W3109911795 cites W2806965041 @default.
• W3109911795 cites W2836250603 @default.
• W3109911795 cites W2875333843 @default.
• W3109911795 cites W2885189035 @default.
• W3109911795 cites W2888447929 @default.
• W3109911795 cites W2912094798 @default.
• W3109911795 cites W2942553366 @default.
• W3109911795 cites W2981809501 @default.
• W3109911795 cites W3001213913 @default.
• W3109911795 cites W3009943130 @default.
• W3109911795 cites W3011079864 @default.
• W3109911795 cites W3027162480 @default.
• W3109911795 cites W3080690702 @default.
• W3109911795 doi "https://doi.org/10.1021/acs.biomac.0c01408" @default.
• W3109911795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33237736" @default.
• W3109911795 hasPublicationYear "2020" @default.
• W3109911795 type Work @default.
• W3109911795 sameAs 3109911795 @default.
• W3109911795 citedByCount "6" @default.
• W3109911795 countsByYear W31099117952021 @default.
• W3109911795 countsByYear W31099117952022 @default.
• W3109911795 crossrefType "journal-article" @default.
• W3109911795 hasAuthorship W3109911795A5003512608 @default.
• W3109911795 hasAuthorship W3109911795A5013278579 @default.
• W3109911795 hasAuthorship W3109911795A5046202195 @default.
• W3109911795 hasAuthorship W3109911795A5046968551 @default.
• W3109911795 hasAuthorship W3109911795A5079826385 @default.
• W3109911795 hasConcept C105702510 @default.
• W3109911795 hasConcept C108586683 @default.
• W3109911795 hasConcept C12554922 @default.
• W3109911795 hasConcept C127413603 @default.
• W3109911795 hasConcept C160160445 @default.
• W3109911795 hasConcept C181199279 @default.
• W3109911795 hasConcept C185592680 @default.
• W3109911795 hasConcept C188027245 @default.
• W3109911795 hasConcept C192562407 @default.
• W3109911795 hasConcept C198826908 @default.
• W3109911795 hasConcept C2776363554 @default.
• W3109911795 hasConcept C2777529286 @default.

• next