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• W3109925267 endingPage "101434" @default.
• W3109925267 startingPage "101434" @default.
• W3109925267 abstract "Decades of basic research has established the importance of Ca2+ to various T cell functions, such as cytotoxicity, proliferation, differentiation and cytokine secretion. We now have a good understanding of how proximal TCR signaling initiates Ca2+ influx and how this influx subsequently changes transcriptional activities in T cells. As chimeric antigen receptor (CAR)-T therapy has achieved great clinical success, is it possible to harness Ca2+ signaling to further advance CAR-T research? How is CAR signaling different from TCR signaling? How can functional CARs be identified in a high-throughput way? Quantification of various Ca2+ signals downstream of CAR/TCR activation might help answer these questions. Here we first summarized recent studies that used Ca2+ dye, genetically-encoded Ca2+ indicators (GECI) or transcriptional activity reporters to understand CAR activation in vitro and in vivo. We next reviewed several proof-of-concept reports that manipulate Ca2+ signaling by light or ultrasound to achieve precise spatiotemporal control of T cell functions. These efforts, though preliminary, opened up new avenues to solve the on-target/off-tumor problem of therapeutic T cells. Other modalities to regulate Ca2+ signaling, such as radio wave and electrical pulse, were also discussed. Thus, monitoring or manipulating Ca2+ signaling in T cells provides us many opportunities to advance cancer immunotherapy." @default.
• W3109925267 created "2020-12-07" @default.
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• W3109925267 date "2020-06-01" @default.
• W3109925267 modified "2023-10-13" @default.
• W3109925267 title "Exploiting Ca2+ signaling in T cells to advance cancer immunotherapy" @default.
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• W3109925267 doi "https://doi.org/10.1016/j.smim.2020.101434" @default.
• W3109925267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33272900" @default.
• W3109925267 hasPublicationYear "2020" @default.
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