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• W3109934588 abstract "Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma and is notorious for its heterogeneity, aggressive nature, and the frequent development of resistance and/or relapse after treatment with standard chemotherapy. To address these problems, a strong emphasis has been placed on researching the molecular origins and mechanisms of DLBCL to develop effective treatments. One of the major insights produced by such research is that DLBCL almost always stems from genetic damage that occurs during the germinal center (GC) reaction, which is required for the production of high-affinity antibodies. Indeed, there is significant overlap between the mechanisms that govern the GC reaction and those that drive the progression of DLBCL. A second important insight is that some of the most frequent genetic mutations that occur in DLBCL are those related to chromatin and epigenetics, especially those related to proteins that “write” histone post-translational modifications (PTMs). Mutation or deletion of these epigenetic writers often renders cells unable to epigenetically “switch on” critical gene sets that are required to exit the GC reaction, differentiate, repair DNA, and other essential cellular functions. Failure to activate these genes locks cells into a genotoxic state that is conducive to oncogenesis and/or relapse." @default.
• W3109934588 created "2020-12-07" @default.
• W3109934588 creator A5022327443 @default.
• W3109934588 creator A5025976155 @default.
• W3109934588 date "2020-12-04" @default.
• W3109934588 modified "2023-10-15" @default.
• W3109934588 title "Genetic and epigenetic determinants of diffuse large B-cell lymphoma" @default.
• W3109934588 cites W1506411711 @default.
• W3109934588 cites W1516310677 @default.
• W3109934588 cites W1519324480 @default.
• W3109934588 cites W1535420127 @default.
• W3109934588 cites W1556521878 @default.
• W3109934588 cites W1881635332 @default.
• W3109934588 cites W1966524014 @default.
• W3109934588 cites W1966652028 @default.
• W3109934588 cites W1967224500 @default.
• W3109934588 cites W1967304777 @default.
• W3109934588 cites W1968758858 @default.
• W3109934588 cites W1969582706 @default.
• W3109934588 cites W1971313898 @default.
• W3109934588 cites W1971400148 @default.
• W3109934588 cites W1971659434 @default.
• W3109934588 cites W1981030303 @default.
• W3109934588 cites W1984179187 @default.
• W3109934588 cites W1987014778 @default.
• W3109934588 cites W1987759895 @default.
• W3109934588 cites W1990711772 @default.
• W3109934588 cites W1995204178 @default.
• W3109934588 cites W1998079194 @default.
• W3109934588 cites W1999505686 @default.
• W3109934588 cites W2001663034 @default.
• W3109934588 cites W2003262666 @default.
• W3109934588 cites W2007861438 @default.
• W3109934588 cites W2009002059 @default.
• W3109934588 cites W2010117150 @default.
• W3109934588 cites W2010711123 @default.
• W3109934588 cites W2017340736 @default.
• W3109934588 cites W2017735587 @default.
• W3109934588 cites W2018071905 @default.
• W3109934588 cites W2019669536 @default.
• W3109934588 cites W2020246476 @default.
• W3109934588 cites W2023032337 @default.
• W3109934588 cites W2024373518 @default.
• W3109934588 cites W2025750579 @default.
• W3109934588 cites W2026496528 @default.
• W3109934588 cites W2036986058 @default.
• W3109934588 cites W2037065120 @default.
• W3109934588 cites W2038204714 @default.
• W3109934588 cites W2042667042 @default.
• W3109934588 cites W2044154548 @default.
• W3109934588 cites W2044352858 @default.
• W3109934588 cites W2045715956 @default.
• W3109934588 cites W2046635524 @default.
• W3109934588 cites W2056521686 @default.
• W3109934588 cites W2056677678 @default.
• W3109934588 cites W2057862856 @default.
• W3109934588 cites W2058015212 @default.
• W3109934588 cites W2061265134 @default.
• W3109934588 cites W2064442490 @default.
• W3109934588 cites W2065292885 @default.
• W3109934588 cites W2068343048 @default.
• W3109934588 cites W2072163745 @default.
• W3109934588 cites W2075855869 @default.
• W3109934588 cites W2082538818 @default.
• W3109934588 cites W2082541302 @default.
• W3109934588 cites W2085293170 @default.
• W3109934588 cites W2090505632 @default.
• W3109934588 cites W2091213817 @default.
• W3109934588 cites W2092818205 @default.
• W3109934588 cites W2094011807 @default.
• W3109934588 cites W2101741321 @default.
• W3109934588 cites W2110467543 @default.
• W3109934588 cites W2117692326 @default.
• W3109934588 cites W2119147717 @default.
• W3109934588 cites W2128243696 @default.
• W3109934588 cites W2130749565 @default.
• W3109934588 cites W2131100258 @default.
• W3109934588 cites W2131314720 @default.
• W3109934588 cites W2132135544 @default.
• W3109934588 cites W2136268782 @default.
• W3109934588 cites W2139942643 @default.
• W3109934588 cites W2143505663 @default.
• W3109934588 cites W2147246240 @default.
• W3109934588 cites W2147594478 @default.
• W3109934588 cites W2148687964 @default.
• W3109934588 cites W2148766088 @default.
• W3109934588 cites W2150382709 @default.
• W3109934588 cites W2152061559 @default.
• W3109934588 cites W2153202563 @default.
• W3109934588 cites W2153598858 @default.
• W3109934588 cites W2158102062 @default.
• W3109934588 cites W2158267770 @default.
• W3109934588 cites W2165608602 @default.
• W3109934588 cites W2166900358 @default.
• W3109934588 cites W2167571754 @default.
• W3109934588 cites W2169012047 @default.
• W3109934588 cites W2171356556 @default.
• W3109934588 cites W2191141911 @default.
• W3109934588 cites W2214176334 @default.
• W3109934588 cites W2216217499 @default.

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