Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109968754> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W3109968754 endingPage "3449" @default.
- W3109968754 startingPage "3442" @default.
- W3109968754 abstract "Non-arteritic anterior ischemic optic neuropathy (NAION) is characterized by the progressive and irreversible death of retinal ganglion cells (RGCs) which is caused by the insufficient blood supply to the optic nerve (ON) head. At present, hormone therapy is used to reduce optic edema, followed by nerve nutrition therapy to protect the ON. However, no surgical or medical therapy has proven to be beneficial consistently in treating NAION. Vincamine is an alkaloid extracted from the Apocynaceae Vinca plant. Vincamine and its derivatives acting as cerebral vasodilators can easily cross the blood-brain barrier, improve the metabolism of ischemic tissue and protect the neuron. In this study, we aimed to investigate the potential neuroprotection of Vincamine in the photodynamic induced rat model of NAION (rAION), to evaluate its effects and possible mechanisms. We found that Vincamine can rescue RGC death and reduce the number of apoptotic cells. The protection of Vincamine might play through the PI3K/Akt/eNOS signaling pathway. Therefore, Vincamine can be an effective therapy method for NAION." @default.
- W3109968754 created "2020-12-07" @default.
- W3109968754 creator A5043019475 @default.
- W3109968754 creator A5046504124 @default.
- W3109968754 creator A5049181863 @default.
- W3109968754 creator A5056022574 @default.
- W3109968754 date "2020-11-21" @default.
- W3109968754 modified "2023-09-27" @default.
- W3109968754 title "Efficacy of Vincamine treatment in a rat model of anterior ischemic optic neuropathy" @default.
- W3109968754 cites W1973512367 @default.
- W3109968754 cites W1979404773 @default.
- W3109968754 cites W1987966362 @default.
- W3109968754 cites W1999453116 @default.
- W3109968754 cites W2005030529 @default.
- W3109968754 cites W2018196680 @default.
- W3109968754 cites W2030198460 @default.
- W3109968754 cites W2053251857 @default.
- W3109968754 cites W2066808276 @default.
- W3109968754 cites W2075350256 @default.
- W3109968754 cites W2080980077 @default.
- W3109968754 cites W2082136833 @default.
- W3109968754 cites W2085330339 @default.
- W3109968754 cites W2085642971 @default.
- W3109968754 cites W2089496439 @default.
- W3109968754 cites W2096369120 @default.
- W3109968754 cites W2114887001 @default.
- W3109968754 cites W2316597594 @default.
- W3109968754 cites W2327359649 @default.
- W3109968754 cites W2602120210 @default.
- W3109968754 cites W4298311249 @default.
- W3109968754 doi "https://doi.org/10.1177/1120672120974283" @default.
- W3109968754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33222520" @default.
- W3109968754 hasPublicationYear "2020" @default.
- W3109968754 type Work @default.
- W3109968754 sameAs 3109968754 @default.
- W3109968754 citedByCount "4" @default.
- W3109968754 countsByYear W31099687542023 @default.
- W3109968754 crossrefType "journal-article" @default.
- W3109968754 hasAuthorship W3109968754A5043019475 @default.
- W3109968754 hasAuthorship W3109968754A5046504124 @default.
- W3109968754 hasAuthorship W3109968754A5049181863 @default.
- W3109968754 hasAuthorship W3109968754A5056022574 @default.
- W3109968754 hasConcept C118487528 @default.
- W3109968754 hasConcept C25498285 @default.
- W3109968754 hasConcept C2776763380 @default.
- W3109968754 hasConcept C2777096885 @default.
- W3109968754 hasConcept C2778233873 @default.
- W3109968754 hasConcept C2780837183 @default.
- W3109968754 hasConcept C42219234 @default.
- W3109968754 hasConcept C71924100 @default.
- W3109968754 hasConcept C98274493 @default.
- W3109968754 hasConceptScore W3109968754C118487528 @default.
- W3109968754 hasConceptScore W3109968754C25498285 @default.
- W3109968754 hasConceptScore W3109968754C2776763380 @default.
- W3109968754 hasConceptScore W3109968754C2777096885 @default.
- W3109968754 hasConceptScore W3109968754C2778233873 @default.
- W3109968754 hasConceptScore W3109968754C2780837183 @default.
- W3109968754 hasConceptScore W3109968754C42219234 @default.
- W3109968754 hasConceptScore W3109968754C71924100 @default.
- W3109968754 hasConceptScore W3109968754C98274493 @default.
- W3109968754 hasIssue "6" @default.
- W3109968754 hasLocation W31099687541 @default.
- W3109968754 hasLocation W31099687542 @default.
- W3109968754 hasOpenAccess W3109968754 @default.
- W3109968754 hasPrimaryLocation W31099687541 @default.
- W3109968754 hasRelatedWork W122931895 @default.
- W3109968754 hasRelatedWork W1964479622 @default.
- W3109968754 hasRelatedWork W1976190570 @default.
- W3109968754 hasRelatedWork W2014091945 @default.
- W3109968754 hasRelatedWork W2034921833 @default.
- W3109968754 hasRelatedWork W2196317040 @default.
- W3109968754 hasRelatedWork W2593592060 @default.
- W3109968754 hasRelatedWork W2988223940 @default.
- W3109968754 hasRelatedWork W3109968754 @default.
- W3109968754 hasRelatedWork W3171467468 @default.
- W3109968754 hasVolume "31" @default.
- W3109968754 isParatext "false" @default.
- W3109968754 isRetracted "false" @default.
- W3109968754 magId "3109968754" @default.
- W3109968754 workType "article" @default.