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- W3109995890 abstract "Psoriasis plaques often recur in the same region and sometimes in the exact area of previous lesions. Some authors have demonstrated that sentinel primed dendritic cells permanently geolocate the areas of the skin, which may explain these areas of relatively exact recurrence. Moreover, persistent structural and immunologic gene changes, a “molecular scar,” have been identified in healed psoriatic lesions post-therapy. Field effects due to local microbiome or other environmental factors may also explain recurrence tendency in the same general area. To explore this phenomenon, we asked patients to recall their lesion distribution history. 42 patients at an academic institution and private practice in Massachusetts and New Jersey were queried with an IRB approved survey in 2017. All patients had dermatologist-diagnosed psoriasis at time of survey. The majority of respondents were male (64%; n = 27) and average age was 52 years old. Most subjects experienced initial psoriasis on the arms or legs (n = 23, 55%). When asked where psoriasis recurred post-treatment, 21% described “same place” recurrence and 66% described it as occurring in the “same place and some new places.” Only 5% described occurring in new places. Subjects who first experienced scalp disease were likely to experience scalp recurrence. Patients with groin disease with expansion were highly likely to expand into the groin area. Our study supports persistent local site activation of psoriasis, particularly at areas with a differential microbiome such as the scalp and groin. These findings may be useful in counseling patients about possible disease extension." @default.
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- W3109995890 date "2020-12-01" @default.
- W3109995890 modified "2023-10-14" @default.
- W3109995890 title "15592 Psoriasis by body region: Does site predict recurrence?" @default.
- W3109995890 doi "https://doi.org/10.1016/j.jaad.2020.06.713" @default.
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