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• W3110053095 endingPage "2587" @default.
• W3110053095 startingPage "2587" @default.
• W3110053095 abstract "Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation, heterochromatization of rDNA units in mouse cells is coupled with the repression or activation of different genes. Furthermore, the nucleoli of human cells shape the direct contacts with genes that are involved in differentiation and cancer. Here, we identified and categorized the genes located in the regions where rDNA clusters make frequent contacts. Using a 4C approach, we demonstrate that in Drosophila S2 cells, rDNA clusters form contacts with genes that are involved in chromosome organization and differentiation. Heat shock treatment induces changes in the contacts between nucleoli and hundreds of genes controlling morphogenesis. We show that nucleoli form contacts with regions that are enriched with active or repressive histone marks and where small non-coding RNAs are mapped. These data indicate that rDNA contacts are involved in the repression and activation of gene expression and that rDNA clusters orchestrate large groups of Drosophila genes involved in differentiation." @default.
• W3110053095 created "2020-12-07" @default.
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• W3110053095 date "2020-12-03" @default.
• W3110053095 modified "2023-10-18" @default.
• W3110053095 title "Dynamics of Whole-Genome Contacts of Nucleoli in Drosophila Cells Suggests a Role for rDNA Genes in Global Epigenetic Regulation" @default.
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• W3110053095 doi "https://doi.org/10.3390/cells9122587" @default.
• W3110053095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7761670" @default.
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• W3110053095 hasPublicationYear "2020" @default.
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