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• W3110057515 startingPage "183" @default.
• W3110057515 abstract "Molecular imaging in bipolar disorder has important pathophysiological and/or clinical relevance in several directions, namely, markers of gliosis, n-acetylaspartate (NAA) level, serotonin transporter binding, aripiprazole occupancy, and quantitation of brain lithium level. Translocator protein (TSPO) imaging with positron emission tomography (PET) indicates that left hippocampal TSPO expression is elevated, which is strongly suggestive of gliosis in this brain region. NAA level is often reduced, particularly, in pediatric bipolar disorder, suggesting loss of mitochondria or mitochondrion-containing structures. Serotonin transporter binding is lower within the midbrain region in bipolar disorder, which may reflect loss of serotonin-releasing neurons in this region. Aripiprazole occupancy plateaus at doses of 10–30 mg daily arguing that raising the dose across this range may be of limited benefit for most clinical cases. Brain lithium not only has slower kinetics that may account for delayed clinical response but also has heterogeneous brain uptake that has implications for optimal targeting of brain structures with this therapeutic. Future directions should focus on imaging markers related to both neuroprogression and illness state." @default.
• W3110057515 created "2020-12-07" @default.
• W3110057515 creator A5045827038 @default.
• W3110057515 date "2021-01-01" @default.
• W3110057515 modified "2023-09-23" @default.
• W3110057515 title "Molecular imaging findings in bipolar disorder" @default.
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