Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110063235> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3110063235 endingPage "320" @default.
- W3110063235 startingPage "314" @default.
- W3110063235 abstract "Background: Essential tremor (ET) and Parkinson's disease (PD) are the two most common movement disorders in adults with similar clinical symptoms, which is hinting towards existence of coincident pathogenesis steps.Objectives: The objective of this report is to characterize the relationship between ET and PD severity and the activity of calcium-dependent proteases calpain in plasma.Methods: The study enrolled 12 volunteers for each condition: ET, PD, healthy. We evaluated the stage of PD on the H&Y scale in patients with PD, and the severity of tremor in patients with ET on the FTMS scale. IL-1β, TNFα, IL6, IL10 were determined in plasma using ELISA. Calpain activity was measured using fluorescent substrate and zymography methods.Results: We demonstrated that the activity of calpains in plasma of patients with PD and ET increased 5.1 and 4.3 times, respectively. The increase of calpain activity in plasma of PD patients correlated with the content of IL-1β, for ET such a connection was not found. At the advanced stages of PD calpain activity in plasma was significantly higher than that of the PD group at the early stage, and this increase was mediated by the increase in m-calpain activity. The increase in the tremor severity in ET did not lead to an increase in the activity of calpains in plasma.Conclusions: We observed general increase in the activity of calpains in plasma of both PD and ET patients that hints towards presence of the common steps in the pathogenesis of these diseases." @default.
- W3110063235 created "2020-12-07" @default.
- W3110063235 creator A5004472693 @default.
- W3110063235 creator A5018884630 @default.
- W3110063235 creator A5024079666 @default.
- W3110063235 creator A5026680139 @default.
- W3110063235 creator A5053570406 @default.
- W3110063235 creator A5077910787 @default.
- W3110063235 date "2020-12-01" @default.
- W3110063235 modified "2023-10-16" @default.
- W3110063235 title "Calpain activity in plasma of patients with essential tremor and Parkinson’s disease: a pilot study" @default.
- W3110063235 cites W1527204253 @default.
- W3110063235 cites W1917565734 @default.
- W3110063235 cites W1966783834 @default.
- W3110063235 cites W1969033401 @default.
- W3110063235 cites W1979444935 @default.
- W3110063235 cites W2027868656 @default.
- W3110063235 cites W2053522766 @default.
- W3110063235 cites W2056145524 @default.
- W3110063235 cites W2064996887 @default.
- W3110063235 cites W2072800541 @default.
- W3110063235 cites W2074229539 @default.
- W3110063235 cites W2096542261 @default.
- W3110063235 cites W2119267323 @default.
- W3110063235 cites W2130356495 @default.
- W3110063235 cites W2137350541 @default.
- W3110063235 cites W2155260991 @default.
- W3110063235 cites W2157854774 @default.
- W3110063235 cites W2169436026 @default.
- W3110063235 cites W2264082276 @default.
- W3110063235 cites W2264507600 @default.
- W3110063235 cites W2494229447 @default.
- W3110063235 cites W2510346966 @default.
- W3110063235 cites W2793037886 @default.
- W3110063235 cites W2969942166 @default.
- W3110063235 cites W3000326778 @default.
- W3110063235 cites W3011074455 @default.
- W3110063235 cites W3016996405 @default.
- W3110063235 cites W4232493852 @default.
- W3110063235 doi "https://doi.org/10.1080/01616412.2020.1854004" @default.
- W3110063235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33729106" @default.
- W3110063235 hasPublicationYear "2020" @default.
- W3110063235 type Work @default.
- W3110063235 sameAs 3110063235 @default.
- W3110063235 citedByCount "3" @default.
- W3110063235 countsByYear W31100632352021 @default.
- W3110063235 countsByYear W31100632352023 @default.
- W3110063235 crossrefType "journal-article" @default.
- W3110063235 hasAuthorship W3110063235A5004472693 @default.
- W3110063235 hasAuthorship W3110063235A5018884630 @default.
- W3110063235 hasAuthorship W3110063235A5024079666 @default.
- W3110063235 hasAuthorship W3110063235A5026680139 @default.
- W3110063235 hasAuthorship W3110063235A5053570406 @default.
- W3110063235 hasAuthorship W3110063235A5077910787 @default.
- W3110063235 hasConcept C109523444 @default.
- W3110063235 hasConcept C126322002 @default.
- W3110063235 hasConcept C134018914 @default.
- W3110063235 hasConcept C177430391 @default.
- W3110063235 hasConcept C181199279 @default.
- W3110063235 hasConcept C182220744 @default.
- W3110063235 hasConcept C185592680 @default.
- W3110063235 hasConcept C2780942790 @default.
- W3110063235 hasConcept C55493867 @default.
- W3110063235 hasConcept C56928146 @default.
- W3110063235 hasConcept C71924100 @default.
- W3110063235 hasConcept C90924648 @default.
- W3110063235 hasConceptScore W3110063235C109523444 @default.
- W3110063235 hasConceptScore W3110063235C126322002 @default.
- W3110063235 hasConceptScore W3110063235C134018914 @default.
- W3110063235 hasConceptScore W3110063235C177430391 @default.
- W3110063235 hasConceptScore W3110063235C181199279 @default.
- W3110063235 hasConceptScore W3110063235C182220744 @default.
- W3110063235 hasConceptScore W3110063235C185592680 @default.
- W3110063235 hasConceptScore W3110063235C2780942790 @default.
- W3110063235 hasConceptScore W3110063235C55493867 @default.
- W3110063235 hasConceptScore W3110063235C56928146 @default.
- W3110063235 hasConceptScore W3110063235C71924100 @default.
- W3110063235 hasConceptScore W3110063235C90924648 @default.
- W3110063235 hasIssue "4" @default.
- W3110063235 hasLocation W31100632351 @default.
- W3110063235 hasLocation W31100632352 @default.
- W3110063235 hasOpenAccess W3110063235 @default.
- W3110063235 hasPrimaryLocation W31100632351 @default.
- W3110063235 hasRelatedWork W1538443565 @default.
- W3110063235 hasRelatedWork W1980439298 @default.
- W3110063235 hasRelatedWork W1995985260 @default.
- W3110063235 hasRelatedWork W2013573744 @default.
- W3110063235 hasRelatedWork W2044157128 @default.
- W3110063235 hasRelatedWork W2066154830 @default.
- W3110063235 hasRelatedWork W2079167666 @default.
- W3110063235 hasRelatedWork W2088141677 @default.
- W3110063235 hasRelatedWork W2625269645 @default.
- W3110063235 hasRelatedWork W400406386 @default.
- W3110063235 hasVolume "43" @default.
- W3110063235 isParatext "false" @default.
- W3110063235 isRetracted "false" @default.
- W3110063235 magId "3110063235" @default.
- W3110063235 workType "article" @default.