Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110076511> ?p ?o ?g. }
- W3110076511 endingPage "8896" @default.
- W3110076511 startingPage "8896" @default.
- W3110076511 abstract "The translation of new therapies for spinal cord injury to clinical trials can be facilitated with large animal models close in morpho-physiological scale to humans. Here, we report functional restoration and morphological reorganization after spinal contusion in pigs, following a combined treatment of locomotor training facilitated with epidural electrical stimulation (EES) and cell-mediated triple gene therapy with umbilical cord blood mononuclear cells overexpressing recombinant vascular endothelial growth factor, glial-derived neurotrophic factor, and neural cell adhesion molecule. Preliminary results obtained on a small sample of pigs 2 months after spinal contusion revealed the difference in post-traumatic spinal cord outcomes in control and treated animals. In treated pigs, motor performance was enabled by EES and the corresponding morpho-functional changes in hind limb skeletal muscles were accompanied by the reorganization of the glial cell, the reaction of stress cell, and synaptic proteins. Our data demonstrate effects of combined EES-facilitated motor training and cell-mediated triple gene therapy after spinal contusion in large animals, informing a background for further animal studies and clinical translation." @default.
- W3110076511 created "2020-12-07" @default.
- W3110076511 creator A5006823693 @default.
- W3110076511 creator A5013445502 @default.
- W3110076511 creator A5021794857 @default.
- W3110076511 creator A5028866812 @default.
- W3110076511 creator A5030019291 @default.
- W3110076511 creator A5045575672 @default.
- W3110076511 creator A5052784113 @default.
- W3110076511 creator A5056399933 @default.
- W3110076511 creator A5063435212 @default.
- W3110076511 creator A5073828136 @default.
- W3110076511 creator A5079139828 @default.
- W3110076511 creator A5086196449 @default.
- W3110076511 creator A5086302863 @default.
- W3110076511 creator A5091529063 @default.
- W3110076511 date "2020-11-24" @default.
- W3110076511 modified "2023-09-27" @default.
- W3110076511 title "Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment" @default.
- W3110076511 cites W1903017783 @default.
- W3110076511 cites W1966693947 @default.
- W3110076511 cites W1967235746 @default.
- W3110076511 cites W1971539206 @default.
- W3110076511 cites W1972742555 @default.
- W3110076511 cites W1985171009 @default.
- W3110076511 cites W1991958278 @default.
- W3110076511 cites W1993476760 @default.
- W3110076511 cites W1996207028 @default.
- W3110076511 cites W1997346812 @default.
- W3110076511 cites W2005985000 @default.
- W3110076511 cites W2009857359 @default.
- W3110076511 cites W2011728205 @default.
- W3110076511 cites W2036455478 @default.
- W3110076511 cites W2036958538 @default.
- W3110076511 cites W2041349035 @default.
- W3110076511 cites W2044754468 @default.
- W3110076511 cites W2046407150 @default.
- W3110076511 cites W2056840154 @default.
- W3110076511 cites W2066055727 @default.
- W3110076511 cites W2066317645 @default.
- W3110076511 cites W2070095638 @default.
- W3110076511 cites W2075007156 @default.
- W3110076511 cites W2080266587 @default.
- W3110076511 cites W2088464857 @default.
- W3110076511 cites W2097341278 @default.
- W3110076511 cites W2114628905 @default.
- W3110076511 cites W2120143347 @default.
- W3110076511 cites W2124248602 @default.
- W3110076511 cites W2127918035 @default.
- W3110076511 cites W2141244009 @default.
- W3110076511 cites W2141594598 @default.
- W3110076511 cites W2142004558 @default.
- W3110076511 cites W2149765121 @default.
- W3110076511 cites W2160816250 @default.
- W3110076511 cites W2161121393 @default.
- W3110076511 cites W2161315339 @default.
- W3110076511 cites W2165946984 @default.
- W3110076511 cites W2203815387 @default.
- W3110076511 cites W2267051237 @default.
- W3110076511 cites W2277097362 @default.
- W3110076511 cites W2322188708 @default.
- W3110076511 cites W2342723950 @default.
- W3110076511 cites W2347530783 @default.
- W3110076511 cites W2412640155 @default.
- W3110076511 cites W2497952843 @default.
- W3110076511 cites W2510020477 @default.
- W3110076511 cites W2532198501 @default.
- W3110076511 cites W2560791438 @default.
- W3110076511 cites W2586297567 @default.
- W3110076511 cites W2588456467 @default.
- W3110076511 cites W2589582036 @default.
- W3110076511 cites W2593584583 @default.
- W3110076511 cites W2594901836 @default.
- W3110076511 cites W2597850348 @default.
- W3110076511 cites W2599061280 @default.
- W3110076511 cites W2604538648 @default.
- W3110076511 cites W2608640383 @default.
- W3110076511 cites W2615064992 @default.
- W3110076511 cites W2617594540 @default.
- W3110076511 cites W2731973505 @default.
- W3110076511 cites W2736485888 @default.
- W3110076511 cites W2760524288 @default.
- W3110076511 cites W2768082937 @default.
- W3110076511 cites W2782326047 @default.
- W3110076511 cites W2792111738 @default.
- W3110076511 cites W2806506369 @default.
- W3110076511 cites W2884008959 @default.
- W3110076511 cites W2885413564 @default.
- W3110076511 cites W2889471742 @default.
- W3110076511 cites W2892074957 @default.
- W3110076511 cites W2898125561 @default.
- W3110076511 cites W2900261340 @default.
- W3110076511 cites W2966119955 @default.
- W3110076511 cites W2991471183 @default.
- W3110076511 cites W3023960453 @default.
- W3110076511 cites W3083792284 @default.
- W3110076511 cites W3088756263 @default.
- W3110076511 cites W33226408 @default.