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- W3110083434 abstract "Sildenafil, approved two decades ago, is the inhibitor of phosphodiesterase 5 (PDE5). First of all, it was designated for angina pectoris, but soon it showed a wonderful efficacy in erectile dysfunction (ED) and then pulmonary arterial hypertension (PAH). Due to the distribution of phosphodiesterase (PDE) in almost all organs, maybe it effects other diseases. Hence, a great number of investigations began to understand the role of PDEi in different organs. Preliminary research on sildenafil in cell culture and animal models has yielded promising results. Soon, a greater number of animal researches and clinical trials joined them. The results disclosed sildenafil can have beneficial effects in each organ such as heart, liver, kidney, brain, and intestines. Furthermore, it has significantly improved the prognosis of organ ischemia in various animal models. Clinical trials in several diseases, such as recurrent spontaneous miscarriage, fatty liver disease, bronchopulmonary dysplasia (BPD), heart failure, and premature ejaculation (PE) brought promising results. Although some clinical trials are available on the effects of sildenafil on various diseases, further studies on humans are needed to consolidate the ultimate effects of sildenafil. The aim of this review was to describe the effects of sildenafil on each organ and explain its mechanisms of action. Further, other PDE inhibitors such as tadalafil and vardenafil have been briefly discussed in parts of this review." @default.
- W3110083434 created "2020-12-07" @default.
- W3110083434 creator A5029077125 @default.
- W3110083434 creator A5034729928 @default.
- W3110083434 creator A5062198742 @default.
- W3110083434 date "2020-12-02" @default.
- W3110083434 modified "2023-10-14" @default.
- W3110083434 title "Sildenafil beyond erectile dysfunction and pulmonary arterial hypertension: Thinking about new indications" @default.
- W3110083434 cites W1577381678 @default.
- W3110083434 cites W1584310709 @default.
- W3110083434 cites W1720082734 @default.
- W3110083434 cites W1722907962 @default.
- W3110083434 cites W1730521963 @default.
- W3110083434 cites W1759854479 @default.
- W3110083434 cites W1792148700 @default.
- W3110083434 cites W1821259897 @default.
- W3110083434 cites W1837726506 @default.
- W3110083434 cites W1956582637 @default.
- W3110083434 cites W1963828794 @default.
- W3110083434 cites W1964408336 @default.
- W3110083434 cites W1969019757 @default.
- W3110083434 cites W1970593736 @default.
- W3110083434 cites W1973082528 @default.
- W3110083434 cites W1973363781 @default.
- W3110083434 cites W1975569148 @default.
- W3110083434 cites W1977855596 @default.
- W3110083434 cites W1978968988 @default.
- W3110083434 cites W1980631317 @default.
- W3110083434 cites W1987906873 @default.
- W3110083434 cites W1988164645 @default.
- W3110083434 cites W1988995007 @default.
- W3110083434 cites W1989610663 @default.
- W3110083434 cites W1990930862 @default.
- W3110083434 cites W1991770656 @default.
- W3110083434 cites W1993946289 @default.
- W3110083434 cites W1994414216 @default.
- W3110083434 cites W1995792973 @default.
- W3110083434 cites W1995980971 @default.
- W3110083434 cites W1997322387 @default.
- W3110083434 cites W1997768760 @default.
- W3110083434 cites W2003309582 @default.
- W3110083434 cites W2005611867 @default.
- W3110083434 cites W2006654512 @default.
- W3110083434 cites W2007069606 @default.
- W3110083434 cites W2010543425 @default.
- W3110083434 cites W2011477996 @default.
- W3110083434 cites W2011671805 @default.
- W3110083434 cites W2012082579 @default.
- W3110083434 cites W2016361419 @default.
- W3110083434 cites W2020808622 @default.
- W3110083434 cites W2021379704 @default.
- W3110083434 cites W2022209603 @default.
- W3110083434 cites W2022255691 @default.
- W3110083434 cites W2024411256 @default.
- W3110083434 cites W2025573005 @default.
- W3110083434 cites W2025593289 @default.
- W3110083434 cites W2028189854 @default.
- W3110083434 cites W2028438112 @default.
- W3110083434 cites W2028597443 @default.
- W3110083434 cites W2030123520 @default.
- W3110083434 cites W2031027703 @default.
- W3110083434 cites W2033852098 @default.
- W3110083434 cites W2034340063 @default.
- W3110083434 cites W2035394623 @default.
- W3110083434 cites W2040684958 @default.
- W3110083434 cites W2040798167 @default.
- W3110083434 cites W2047462308 @default.
- W3110083434 cites W2048356178 @default.
- W3110083434 cites W2049815384 @default.
- W3110083434 cites W2050093658 @default.
- W3110083434 cites W2052113937 @default.
- W3110083434 cites W2054818418 @default.
- W3110083434 cites W2058427553 @default.
- W3110083434 cites W2060228093 @default.
- W3110083434 cites W2061246838 @default.
- W3110083434 cites W2062244338 @default.
- W3110083434 cites W2073501412 @default.
- W3110083434 cites W2074607629 @default.
- W3110083434 cites W2075833457 @default.
- W3110083434 cites W2076000224 @default.
- W3110083434 cites W2080710617 @default.
- W3110083434 cites W2084224669 @default.
- W3110083434 cites W2087676599 @default.
- W3110083434 cites W2093264839 @default.
- W3110083434 cites W2093504658 @default.
- W3110083434 cites W2096107056 @default.
- W3110083434 cites W2096657598 @default.
- W3110083434 cites W2100334760 @default.
- W3110083434 cites W2100698386 @default.
- W3110083434 cites W2108999152 @default.
- W3110083434 cites W2111312680 @default.
- W3110083434 cites W2118811017 @default.
- W3110083434 cites W2118981005 @default.
- W3110083434 cites W2123836172 @default.
- W3110083434 cites W2124140210 @default.
- W3110083434 cites W2126020984 @default.
- W3110083434 cites W2127994875 @default.
- W3110083434 cites W2138365326 @default.