FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110129168> ?p ?o ?g. }

• W3110129168 endingPage "127715" @default.
• W3110129168 startingPage "127715" @default.
• W3110129168 abstract "The effects of 3 bufadienolides, namely kalantuboside B, kalantuboside A, and bryotoxin C, isolated from Kalanchoe tubiflora (Harvey) were evaluated and characterized in CL1-5 highly metastatic human lung cancer cells. In contrast to their apoptosis-promoting activity in other cancer cells, these bufadienolides only slight or did not induce apoptosis in CL1-5 cancer cells. Instead, they activated an autophagy pathway, as indicated by increased autophagosome formation. Autophagy induced by these bufadienolides was demonstrated to be linked to the down-regulation of p-mTOR and the up-regulation of LC3-II, ATG5, ATG7, and Beclin-1. Our findings revealed an autophagy as the alternative mechanism of drug action by bufadienolides in CL1-5 lung cancer cells and provided evidence that bufadienolides are a potential therapeutic strategy for highly metastatic human lung cancer." @default.
• W3110129168 created "2020-12-07" @default.
• W3110129168 creator A5010500131 @default.
• W3110129168 creator A5038733052 @default.
• W3110129168 creator A5042151372 @default.
• W3110129168 creator A5048426265 @default.
• W3110129168 creator A5071497553 @default.
• W3110129168 creator A5072558939 @default.
• W3110129168 creator A5085931685 @default.
• W3110129168 date "2021-01-01" @default.
• W3110129168 modified "2023-10-16" @default.
• W3110129168 title "Three bufadienolides induce cell death in the human lung cancer cell line CL1‐5 mainly through autophagy" @default.
• W3110129168 cites W1970637701 @default.
• W3110129168 cites W1981337355 @default.
• W3110129168 cites W1982883159 @default.
• W3110129168 cites W1984060790 @default.
• W3110129168 cites W1993643473 @default.
• W3110129168 cites W2017981926 @default.
• W3110129168 cites W2018527946 @default.
• W3110129168 cites W2028304108 @default.
• W3110129168 cites W2046205790 @default.
• W3110129168 cites W2049528479 @default.
• W3110129168 cites W2061178082 @default.
• W3110129168 cites W2061473417 @default.
• W3110129168 cites W2066663982 @default.
• W3110129168 cites W2067817634 @default.
• W3110129168 cites W2082448808 @default.
• W3110129168 cites W2085169607 @default.
• W3110129168 cites W2097632835 @default.
• W3110129168 cites W2120595804 @default.
• W3110129168 cites W2123173445 @default.
• W3110129168 cites W2125565327 @default.
• W3110129168 cites W2135574023 @default.
• W3110129168 cites W2139236349 @default.
• W3110129168 cites W2146124002 @default.
• W3110129168 cites W2159372512 @default.
• W3110129168 cites W2161821474 @default.
• W3110129168 cites W2184224810 @default.
• W3110129168 cites W2295248271 @default.
• W3110129168 cites W2313573220 @default.
• W3110129168 cites W2330069610 @default.
• W3110129168 cites W2487150856 @default.
• W3110129168 cites W2587125658 @default.
• W3110129168 cites W2606261115 @default.
• W3110129168 cites W2752326209 @default.
• W3110129168 cites W2920997498 @default.
• W3110129168 cites W2937346106 @default.
• W3110129168 doi "https://doi.org/10.1016/j.bmcl.2020.127715" @default.
• W3110129168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33246109" @default.
• W3110129168 hasPublicationYear "2021" @default.
• W3110129168 type Work @default.
• W3110129168 sameAs 3110129168 @default.
• W3110129168 citedByCount "4" @default.
• W3110129168 countsByYear W31101291682022 @default.
• W3110129168 countsByYear W31101291682023 @default.
• W3110129168 crossrefType "journal-article" @default.
• W3110129168 hasAuthorship W3110129168A5010500131 @default.
• W3110129168 hasAuthorship W3110129168A5038733052 @default.
• W3110129168 hasAuthorship W3110129168A5042151372 @default.
• W3110129168 hasAuthorship W3110129168A5048426265 @default.
• W3110129168 hasAuthorship W3110129168A5071497553 @default.
• W3110129168 hasAuthorship W3110129168A5072558939 @default.
• W3110129168 hasAuthorship W3110129168A5085931685 @default.
• W3110129168 hasConcept C121608353 @default.
• W3110129168 hasConcept C126322002 @default.
• W3110129168 hasConcept C185592680 @default.
• W3110129168 hasConcept C190283241 @default.
• W3110129168 hasConcept C203522944 @default.
• W3110129168 hasConcept C2776256026 @default.
• W3110129168 hasConcept C2781000418 @default.
• W3110129168 hasConcept C31573885 @default.
• W3110129168 hasConcept C502942594 @default.
• W3110129168 hasConcept C54355233 @default.
• W3110129168 hasConcept C55493867 @default.
• W3110129168 hasConcept C71924100 @default.
• W3110129168 hasConcept C81885089 @default.
• W3110129168 hasConcept C86554907 @default.
• W3110129168 hasConcept C86803240 @default.
• W3110129168 hasConcept C95444343 @default.
• W3110129168 hasConcept C96232424 @default.
• W3110129168 hasConcept C98274493 @default.
• W3110129168 hasConceptScore W3110129168C121608353 @default.
• W3110129168 hasConceptScore W3110129168C126322002 @default.
• W3110129168 hasConceptScore W3110129168C185592680 @default.
• W3110129168 hasConceptScore W3110129168C190283241 @default.
• W3110129168 hasConceptScore W3110129168C203522944 @default.
• W3110129168 hasConceptScore W3110129168C2776256026 @default.
• W3110129168 hasConceptScore W3110129168C2781000418 @default.
• W3110129168 hasConceptScore W3110129168C31573885 @default.
• W3110129168 hasConceptScore W3110129168C502942594 @default.
• W3110129168 hasConceptScore W3110129168C54355233 @default.
• W3110129168 hasConceptScore W3110129168C55493867 @default.
• W3110129168 hasConceptScore W3110129168C71924100 @default.
• W3110129168 hasConceptScore W3110129168C81885089 @default.
• W3110129168 hasConceptScore W3110129168C86554907 @default.
• W3110129168 hasConceptScore W3110129168C86803240 @default.
• W3110129168 hasConceptScore W3110129168C95444343 @default.
• W3110129168 hasConceptScore W3110129168C96232424 @default.

• next