FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110130544> ?p ?o ?g. }

• W3110130544 endingPage "34" @default.
• W3110130544 startingPage "34" @default.
• W3110130544 abstract "Purpose: The role of activated retinal microglia in driving retinal degeneration has been implicated in a number of in vivo disease models. Here, we investigated the primary consequences of microglial activation by the specific expression of constitutively active Ras in microglia in a transgenic mouse model before the onset of any degenerative changes in the retina. Methods: The double transgenic lines CAG-LSL-RasV12-IRES-EGFP; Cx3cr1CreER/+ (Cx3cr1-RasV12 mice) and CAG-LSL-EGFP; Cx3cr1CreER_+ (control mice) were generated. The expression of RasV12 was induced in microglia by tamoxifen administration, and the retinas were examined by immunohistochemistry of frozen sections, RT-qPCR, and live imaging. Results: RasV12 expression in retinal microglial cells promoted cell proliferation, cytokine expression, and phagocytosis. RasV12-expressing microglia migrated toward the inner and outer layers of the retina. Examination of glial fibrillary acidic protein (GFAP) expression revealed activation of Müller glia in the retina. We also observed loss of the photoreceptors in the outer nuclear layer in close proximity to microglial cells. However, no significant neurodegeneration was detected in the inner nuclear layer (INL) or ganglion cell layer (GCL). The morphology of RasV12-expressing microglia in the GCL and INL retained more ramified features compared with the predominantly-ameboid morphology found in outer retinal microglia. Conclusions: The expression of RasV12 is sufficient to activate microglia and lead to photoreceptor degeneration. Neurons in the inner side of the retina were not damaged by the RasV12-activated microglia, suggesting that microenvironment cues may modulate the microglial phenotypic features and effects of microglial activation." @default.
• W3110130544 created "2020-12-07" @default.
• W3110130544 creator A5003580639 @default.
• W3110130544 creator A5009719036 @default.
• W3110130544 creator A5049133868 @default.
• W3110130544 creator A5061143255 @default.
• W3110130544 creator A5075064138 @default.
• W3110130544 creator A5084916157 @default.
• W3110130544 date "2020-11-24" @default.
• W3110130544 modified "2023-10-16" @default.
• W3110130544 title "RasV12 Expression in Microglia Initiates Retinal Inflammation and Induces Photoreceptor Degeneration" @default.
• W3110130544 cites W1817666133 @default.
• W3110130544 cites W1973234671 @default.
• W3110130544 cites W1998314896 @default.
• W3110130544 cites W2008009288 @default.
• W3110130544 cites W2022180260 @default.
• W3110130544 cites W2022585532 @default.
• W3110130544 cites W2027620575 @default.
• W3110130544 cites W2032410318 @default.
• W3110130544 cites W2040196938 @default.
• W3110130544 cites W2043410669 @default.
• W3110130544 cites W2059000778 @default.
• W3110130544 cites W2074832091 @default.
• W3110130544 cites W2078532650 @default.
• W3110130544 cites W2106910268 @default.
• W3110130544 cites W2125393554 @default.
• W3110130544 cites W2132513445 @default.
• W3110130544 cites W2141267422 @default.
• W3110130544 cites W2142154718 @default.
• W3110130544 cites W2150724604 @default.
• W3110130544 cites W2153406260 @default.
• W3110130544 cites W2161282095 @default.
• W3110130544 cites W2275354472 @default.
• W3110130544 cites W2280077905 @default.
• W3110130544 cites W2488258517 @default.
• W3110130544 cites W2605948639 @default.
• W3110130544 cites W2732767128 @default.
• W3110130544 cites W2735674855 @default.
• W3110130544 cites W2743727231 @default.
• W3110130544 cites W2750719748 @default.
• W3110130544 cites W2753593979 @default.
• W3110130544 cites W2806766888 @default.
• W3110130544 cites W2909426653 @default.
• W3110130544 cites W3013377779 @default.
• W3110130544 cites W4233933504 @default.
• W3110130544 cites W4251883438 @default.
• W3110130544 doi "https://doi.org/10.1167/iovs.61.13.34" @default.
• W3110130544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7691791" @default.
• W3110130544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33231622" @default.
• W3110130544 hasPublicationYear "2020" @default.
• W3110130544 type Work @default.
• W3110130544 sameAs 3110130544 @default.
• W3110130544 citedByCount "7" @default.
• W3110130544 countsByYear W31101305442021 @default.
• W3110130544 countsByYear W31101305442022 @default.
• W3110130544 countsByYear W31101305442023 @default.
• W3110130544 crossrefType "journal-article" @default.
• W3110130544 hasAuthorship W3110130544A5003580639 @default.
• W3110130544 hasAuthorship W3110130544A5009719036 @default.
• W3110130544 hasAuthorship W3110130544A5049133868 @default.
• W3110130544 hasAuthorship W3110130544A5061143255 @default.
• W3110130544 hasAuthorship W3110130544A5075064138 @default.
• W3110130544 hasAuthorship W3110130544A5084916157 @default.
• W3110130544 hasBestOaLocation W31101305441 @default.
• W3110130544 hasConcept C142724271 @default.
• W3110130544 hasConcept C169760540 @default.
• W3110130544 hasConcept C203014093 @default.
• W3110130544 hasConcept C204232928 @default.
• W3110130544 hasConcept C2776914184 @default.
• W3110130544 hasConcept C2776925932 @default.
• W3110130544 hasConcept C2777093970 @default.
• W3110130544 hasConcept C2777506830 @default.
• W3110130544 hasConcept C2777585161 @default.
• W3110130544 hasConcept C2778231335 @default.
• W3110130544 hasConcept C2779134260 @default.
• W3110130544 hasConcept C2779830541 @default.
• W3110130544 hasConcept C2780188069 @default.
• W3110130544 hasConcept C2780495277 @default.
• W3110130544 hasConcept C2780827179 @default.
• W3110130544 hasConcept C2780884517 @default.
• W3110130544 hasConcept C2781040256 @default.
• W3110130544 hasConcept C529278444 @default.
• W3110130544 hasConcept C55493867 @default.
• W3110130544 hasConcept C71924100 @default.
• W3110130544 hasConcept C86803240 @default.
• W3110130544 hasConcept C95444343 @default.
• W3110130544 hasConceptScore W3110130544C142724271 @default.
• W3110130544 hasConceptScore W3110130544C169760540 @default.
• W3110130544 hasConceptScore W3110130544C203014093 @default.
• W3110130544 hasConceptScore W3110130544C204232928 @default.
• W3110130544 hasConceptScore W3110130544C2776914184 @default.
• W3110130544 hasConceptScore W3110130544C2776925932 @default.
• W3110130544 hasConceptScore W3110130544C2777093970 @default.
• W3110130544 hasConceptScore W3110130544C2777506830 @default.
• W3110130544 hasConceptScore W3110130544C2777585161 @default.
• W3110130544 hasConceptScore W3110130544C2778231335 @default.
• W3110130544 hasConceptScore W3110130544C2779134260 @default.
• W3110130544 hasConceptScore W3110130544C2779830541 @default.

• next