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- W3110149345 endingPage "725" @default.
- W3110149345 startingPage "711" @default.
- W3110149345 abstract "Abstract The combination of the immunotherapy (i.e., the use of monoclonal antibodies) and the conventional chemotherapy increases the long-term survival of patients with lymphoma. However, for patients with relapsed or treatment-resistant lymphoma, a novel treatment approach is urgently needed. Chimeric antigen receptor T (CAR-T) cells were introduced as a treatment for these patients. Based on recent clinical data, approximately 50% of patients with relapsed or refractory B-cell lymphoma achieved complete remission after receiving the CD19 CAR-T cell therapy. Moreover, clinical data revealed that some patients remained in remission for more than two years after the CAR-T cell therapy. Other than the CD19-targeted CAR-T, the novel target antigens, such as CD20, CD22, CD30, and CD37, which were greatly expressed on lymphoma cells, were studied under preclinical and clinical evaluations for use in the treatment of lymphoma. Nonetheless, the CAR-T therapy was usually associated with potentially lethal adverse effects, such as the cytokine release syndrome and the neurotoxicity. Therefore, optimizing the structure of CAR, creating new drugs, and combining CAR-T cell therapy with stem cell transplantation are potential solutions to increase the effectiveness of treatment and reduce the toxicity in patients with lymphoma after the CAR-T cell therapy." @default.
- W3110149345 created "2020-12-07" @default.
- W3110149345 creator A5013028494 @default.
- W3110149345 creator A5013886326 @default.
- W3110149345 creator A5014867753 @default.
- W3110149345 creator A5041081914 @default.
- W3110149345 creator A5079962110 @default.
- W3110149345 creator A5090013547 @default.
- W3110149345 date "2020-12-01" @default.
- W3110149345 modified "2023-10-10" @default.
- W3110149345 title "A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma" @default.
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