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- W3110154391 abstract "We have read with great interest the article by Hung et al1Hung K.W. et al.Clin Gastroenterol Hepatol. 2020; 18: 1091-1098Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar reporting the adherence to Helicobacter pylori testing in patients who were treated endoscopically for bleeding and gastric ulcers during their hospital stay. This study showed a surprising lack of proper H pylori testing, especially in critically ill patients, which reflects a very important clinical challenge. We hope that the authors can present some data to help us better understand the results of this study, and we would also like to discuss an appropriate method of H pylori testing. First, we speculate that patients’ activities of daily living (ADLs) and clinical outcomes affected their adherence to H pylori testing in the current study. Intensive care unit (ICU) admission was a factor in avoiding H pylori testing, which the authors speculated was caused by active bleeding that caused the endoscopist to refrain from obtaining a biopsy.1Hung K.W. et al.Clin Gastroenterol Hepatol. 2020; 18: 1091-1098Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar Bleeding in gastric and duodenal ulcers in the United States is associated with H pylori infection in 61%–95.9% of cases,2Ciociola A.A. et al.Am J Gastroenterol. 1999; 94: 1834-1840Crossref PubMed Scopus (197) Google Scholar,3Jyotheeswaran S. et al.Am J Gastroenterol. 1998; 93: 574-578Crossref PubMed Scopus (142) Google Scholar and ulcer recurrence after H pylori eradication has been reported to occur in 0.5% of cases.4Gisbert J.P. et al.Am J Gastroenterol. 2012; 107: 1197-1204Crossref PubMed Scopus (56) Google Scholar Essentially, patients who are critically ill because of ulcer bleeding should be the highest priority patients for H pylori testing. The difficulty in testing for H pylori in patients admitted to the ICU cannot be explained only by the lack of knowledge on the part of health care providers. We believe that the presence of patient factors as barriers for proper testing in severely ill patients should be considered separately. For example, physicians may refrain from testing when patients have other serious diseases, such as cancer or serious heart disease, or when the patients' ADLs are poor, and therefore, they may experience difficulties living independently after discharge from the hospital. We would like the authors to present information on the patients’ outcome at discharge, the presence or absence of malignant disease, and their ADLs. Second, an analysis on the part of health care providers is also necessary. The present study was conducted in patients who underwent endoscopic treatment for gastric and duodenal ulcers during hospitalization. Although it was stated that all evaluations involved a consultant gastroenterologist, patients in the ICU may have multiple comorbidities other than gastrointestinal diseases. In other words, the lack of testing among patients in the ICU may be caused by poor coordination between gastroenterologists and ICU teams. If so, a review of the hospital's workflow would help improve adherence to H pylori testing. Finally, close care must be taken for the method of H pylori testing. As the authors pointed out, performing biopsies in patients with bleeding gastrointestinal ulcers is a valid approach. However, it should be noted that the biopsy method has low sensitivity for the detection of H pylori. The sensitivities of the direct speculum and culture methods for the detection of H pylori in patients with bleeding ulcers are 70% and 45%, respectively,5Gisbert J.P. et al.Am J Gastroenterol. 2006; 101: 848-863Crossref PubMed Scopus (153) Google Scholar and the biopsy urease test has a false-negative rate of 25%.6Lee J.M. et al.Am J Gastroenterol. 2000; 95: 1166-1170Crossref PubMed Google Scholar In the United States, there may be restrictions on H pylori testing at facilities (which may be associated with testing equipment and sometimes insurance), but we must combine biopsy with other methods for the accurate detection of H pylori, such as antibody and stool tests, and create an always suspect H pylori mentality. Factors Associated With Adherence to Helicobacter pylori Testing During Hospitalization for Bleeding Peptic Ulcer DiseaseClinical Gastroenterology and HepatologyVol. 18Issue 5PreviewGuidelines recommend testing patients with peptic ulcer disease for Helicobacter pylori infection. We sought to identify factors associated with adherence to testing for H pylori in patients hospitalized for bleeding ulcers and to evaluate whether performing these tests affect risk for rebleeding. Full-Text PDF ReplyClinical Gastroenterology and HepatologyVol. 19Issue 6PreviewSaito and colleagues raise 2 related questions about our study, which found a decreased rate of Helicobacter pylori testing among patients hospitalized with bleeding ulcers in the intensive care unit (ICU) compared with those on regular hospital wards.1 First, they ask whether patient factors may have explained the low (66%) observed rate of H pylori testing among ICU patients with bleeding ulcers. Second, they question whether provider factors, including lack of coordination of care, may have been the cause. Full-Text PDF" @default.
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- W3110154391 date "2021-06-01" @default.
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- W3110154391 title "Patient Outcomes and Environment May Affect Adherence to Helicobacter pylori Testing" @default.
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- W3110154391 doi "https://doi.org/10.1016/j.cgh.2020.07.002" @default.
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