Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110164542> ?p ?o ?g. }
- W3110164542 endingPage "9467" @default.
- W3110164542 startingPage "9447" @default.
- W3110164542 abstract "Nanomedicines (NMs) have played an increasing role in cancer therapy as carriers to efficiently deliver therapeutics into tumor cells. For this application, the uptake of NMs by tumor cells is usually a prerequisite to deliver the cargo to intracellular locations, which mainly relies on endocytosis. NMs can enter cells through a variety of endocytosis pathways. Different endocytosis pathways exhibit different intracellular trafficking routes and diverse subcellular localizations. Therefore, a comprehensive understanding of endocytosis mechanisms is necessary for increasing cellular entry efficiency and to trace the fate of NMs after internalization. This review focuses on endocytosis pathways of NMs in tumor cells, mainly including clathrin- and caveolae-mediated endocytosis pathways, involving effector molecules, expression difference of those molecules between normal and tumor cells, as well as the intracellular trafficking route of corresponding endocytosis vesicles. Then, the latest strategies for NMs to actively employ endocytosis are described, including improving tumor cellular uptake of NMs by receptor-mediated endocytosis, transporter-mediated endocytosis and enabling drug activity by changing intracellular routes. Finally, active targeting strategies towards intracellular organelles are also mentioned. This review will be helpful not only in explicating endocytosis and the trafficking process of NMs and elucidating anti-tumor mechanisms inside the cell but also in rendering new ideas for the design of highly efficacious and cancer-targeted NMs." @default.
- W3110164542 created "2020-12-07" @default.
- W3110164542 creator A5002650576 @default.
- W3110164542 creator A5007045422 @default.
- W3110164542 creator A5020844959 @default.
- W3110164542 creator A5022814673 @default.
- W3110164542 creator A5026330010 @default.
- W3110164542 creator A5052935510 @default.
- W3110164542 creator A5053706585 @default.
- W3110164542 creator A5068430004 @default.
- W3110164542 creator A5072510066 @default.
- W3110164542 creator A5090270861 @default.
- W3110164542 date "2020-11-01" @default.
- W3110164542 modified "2023-10-14" @default.
- W3110164542 title "<p>Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy</p>" @default.
- W3110164542 cites W1526451509 @default.
- W3110164542 cites W1607766894 @default.
- W3110164542 cites W1902159756 @default.
- W3110164542 cites W1971163393 @default.
- W3110164542 cites W1972708772 @default.
- W3110164542 cites W1973356985 @default.
- W3110164542 cites W1974302367 @default.
- W3110164542 cites W1974740818 @default.
- W3110164542 cites W1974892535 @default.
- W3110164542 cites W1978880171 @default.
- W3110164542 cites W1981076611 @default.
- W3110164542 cites W1982002204 @default.
- W3110164542 cites W1985126638 @default.
- W3110164542 cites W1987355699 @default.
- W3110164542 cites W1987735951 @default.
- W3110164542 cites W1989230986 @default.
- W3110164542 cites W1991032925 @default.
- W3110164542 cites W1991424808 @default.
- W3110164542 cites W1995953743 @default.
- W3110164542 cites W2002594335 @default.
- W3110164542 cites W2003110090 @default.
- W3110164542 cites W2005993715 @default.
- W3110164542 cites W2006895250 @default.
- W3110164542 cites W2008033906 @default.
- W3110164542 cites W2009644972 @default.
- W3110164542 cites W2011030869 @default.
- W3110164542 cites W2012989300 @default.
- W3110164542 cites W2014356856 @default.
- W3110164542 cites W2015497529 @default.
- W3110164542 cites W2016559074 @default.
- W3110164542 cites W2017201573 @default.
- W3110164542 cites W2022373265 @default.
- W3110164542 cites W2022406746 @default.
- W3110164542 cites W2023863818 @default.
- W3110164542 cites W2028431915 @default.
- W3110164542 cites W2030727312 @default.
- W3110164542 cites W2032760352 @default.
- W3110164542 cites W2033612573 @default.
- W3110164542 cites W2037403702 @default.
- W3110164542 cites W2038717222 @default.
- W3110164542 cites W2041143337 @default.
- W3110164542 cites W2041164141 @default.
- W3110164542 cites W2041521061 @default.
- W3110164542 cites W2044696771 @default.
- W3110164542 cites W2046133662 @default.
- W3110164542 cites W2046398431 @default.
- W3110164542 cites W2046516625 @default.
- W3110164542 cites W2047936567 @default.
- W3110164542 cites W2051271385 @default.
- W3110164542 cites W2051826082 @default.
- W3110164542 cites W2057650100 @default.
- W3110164542 cites W2064349006 @default.
- W3110164542 cites W2065902356 @default.
- W3110164542 cites W2069444054 @default.
- W3110164542 cites W2069820370 @default.
- W3110164542 cites W2074929394 @default.
- W3110164542 cites W2077142078 @default.
- W3110164542 cites W2077748639 @default.
- W3110164542 cites W2081712965 @default.
- W3110164542 cites W2084973104 @default.
- W3110164542 cites W2087581976 @default.
- W3110164542 cites W2087591542 @default.
- W3110164542 cites W2087824631 @default.
- W3110164542 cites W2093231351 @default.
- W3110164542 cites W2094439964 @default.
- W3110164542 cites W2096054643 @default.
- W3110164542 cites W2096154351 @default.
- W3110164542 cites W2103310968 @default.
- W3110164542 cites W2104808978 @default.
- W3110164542 cites W2106474898 @default.
- W3110164542 cites W2108517741 @default.
- W3110164542 cites W2111724662 @default.
- W3110164542 cites W2113972541 @default.
- W3110164542 cites W2123647020 @default.
- W3110164542 cites W2126044151 @default.
- W3110164542 cites W2126460855 @default.
- W3110164542 cites W2128168622 @default.
- W3110164542 cites W2128963767 @default.
- W3110164542 cites W2129765036 @default.
- W3110164542 cites W2132510033 @default.
- W3110164542 cites W2134992227 @default.
- W3110164542 cites W2136558879 @default.
- W3110164542 cites W2139333712 @default.