FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110179297> ?p ?o ?g. }

• W3110179297 abstract "Introduction: While CI, or the inability of heart rate (HR) to adequately respond to exercise, is a strong indicator of mortality in HFpEF, treatment options remain limited as its mechanisms remain underexplored. Ionic remodeling of the SAN, both of the membrane (MC) and calcium clocks (CC), is associated with HFpEF and CI. Aim: Using an in silico approach, we investigated whether SAN ionic remodeling can contribute to 3 different CI presentations (Fig A) and explored the effectiveness of targeting the remodeling of the MC or CC (MCR and CCR, resp.) in eliminating CI. Methods: A human SAN model (control) was used, in which ionic remodeling was integrated using experimental data from HFpEF rat model with CI (Fig B top). A family of HFpEF SAN models (n = 147) was generated because the uniqueness of Ca 2+ handling parameters constrained to experimentally-based Ca 2+ transients could not be guaranteed (Fig B middle). To assess the level of CI, max beat rate (BR), BR response (τ on ), and BR recovery (τ off ) were quantified for each model in response to a transient 40s pulse of 1 μM isoproterenol (ISO) (Fig B bottom). Lastly, the effect of reversing either CCR or MCR on CI was determined. Results: Without ISO, BR of HFpEF SAN models was similar to that of control; when ISO was applied (Fig C), HFpEF models exhibited all aspects of CI: submaximal BR (Fig D), and elevated τ on and τ off (Fig E). In CCR reversed models, BR without ISO was similar to that of control; with ISO, they exhibited submaximal BR (Fig F). In MCR reversed models, BR without ISO was slightly lower compared to control; with ISO, while they exhibited submaximal BR, the increase in BR with ISO was similar to that of control (Fig F). τ on and τ off were elevated in CCR reversed models, but they were not in MCR reversed models (Fig G). In summary, CCR reversed models exhibited all aspects of CI, but MCR reversed models did not. Conclusion: Ionic remodeling of the SAN contributes to CI in HFpEF, and targeting MCR could be a promising strategy for eliminating CI." @default.
• W3110179297 created "2020-12-07" @default.
• W3110179297 creator A5006408118 @default.
• W3110179297 creator A5018520387 @default.
• W3110179297 creator A5020569461 @default.
• W3110179297 creator A5046381230 @default.
• W3110179297 creator A5070924694 @default.
• W3110179297 creator A5076400432 @default.
• W3110179297 creator A5084628971 @default.
• W3110179297 date "2020-11-17" @default.
• W3110179297 modified "2023-09-27" @default.
• W3110179297 title "Abstract 17006: Reversing Membrane Clock Remodeling (MCR) Associated With Heart Failure With Preserved Ejection Fraction (HFpEF) in the Sinoatrial Node (SAN) Eliminates Chronotropic Incompetence (CI)" @default.
• W3110179297 doi "https://doi.org/10.1161/circ.142.suppl_3.17006" @default.
• W3110179297 hasPublicationYear "2020" @default.
• W3110179297 type Work @default.
• W3110179297 sameAs 3110179297 @default.
• W3110179297 citedByCount "0" @default.
• W3110179297 crossrefType "journal-article" @default.
• W3110179297 hasAuthorship W3110179297A5006408118 @default.
• W3110179297 hasAuthorship W3110179297A5018520387 @default.
• W3110179297 hasAuthorship W3110179297A5020569461 @default.
• W3110179297 hasAuthorship W3110179297A5046381230 @default.
• W3110179297 hasAuthorship W3110179297A5070924694 @default.
• W3110179297 hasAuthorship W3110179297A5076400432 @default.
• W3110179297 hasAuthorship W3110179297A5084628971 @default.
• W3110179297 hasConcept C126322002 @default.
• W3110179297 hasConcept C158328960 @default.
• W3110179297 hasConcept C164705383 @default.
• W3110179297 hasConcept C2777099384 @default.
• W3110179297 hasConcept C2777953023 @default.
• W3110179297 hasConcept C2778198053 @default.
• W3110179297 hasConcept C2779537366 @default.
• W3110179297 hasConcept C71924100 @default.
• W3110179297 hasConcept C78085059 @default.
• W3110179297 hasConcept C84393581 @default.
• W3110179297 hasConceptScore W3110179297C126322002 @default.
• W3110179297 hasConceptScore W3110179297C158328960 @default.
• W3110179297 hasConceptScore W3110179297C164705383 @default.
• W3110179297 hasConceptScore W3110179297C2777099384 @default.
• W3110179297 hasConceptScore W3110179297C2777953023 @default.
• W3110179297 hasConceptScore W3110179297C2778198053 @default.
• W3110179297 hasConceptScore W3110179297C2779537366 @default.
• W3110179297 hasConceptScore W3110179297C71924100 @default.
• W3110179297 hasConceptScore W3110179297C78085059 @default.
• W3110179297 hasConceptScore W3110179297C84393581 @default.
• W3110179297 hasIssue "Suppl_3" @default.
• W3110179297 hasLocation W31101792971 @default.
• W3110179297 hasOpenAccess W3110179297 @default.
• W3110179297 hasPrimaryLocation W31101792971 @default.
• W3110179297 hasRelatedWork W2027691053 @default.
• W3110179297 hasRelatedWork W2061321770 @default.
• W3110179297 hasRelatedWork W2327585969 @default.
• W3110179297 hasRelatedWork W2364214674 @default.
• W3110179297 hasRelatedWork W2789205885 @default.
• W3110179297 hasRelatedWork W2922135971 @default.
• W3110179297 hasRelatedWork W2965474825 @default.
• W3110179297 hasRelatedWork W3033076790 @default.
• W3110179297 hasRelatedWork W3157316619 @default.
• W3110179297 hasRelatedWork W3165187768 @default.
• W3110179297 hasVolume "142" @default.
• W3110179297 isParatext "false" @default.
• W3110179297 isRetracted "false" @default.
• W3110179297 magId "3110179297" @default.
• W3110179297 workType "article" @default.