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• W3110187975 abstract "The p75 neurotrophin receptor (p75 NTR ), a member of the tumor necrosis factor superfamily of receptors, is sensitive to proteolysis and has been observed to be expressed in various cancers. However, the roles of p75 NTR and its proteolytic fragments in tumorigenesis remain incompletely understood. Here, we report that the proportion of the p75 NTR carboxyl‐terminal fragment (p75 NTR ‐CTF) is much higher than that of the full‐length p75 NTR (p75 NTR ‐FL) in melanoma cells. Whereas p75 NTR ‐FL positively regulates apoptosis, p75 NTR ‐CTF promotes cell proliferation and survival, as well as increasing sorafenib resistance in vivo and in vitro . Moreover, p75 NTR ‐CTF activates the nuclear factor kappa B pathway and enhances the mRNA and protein levels of its downstream genes c‐IAP1/2 , FLIP , bFGF , IL8 and VEGF . On the contrary, p75 NTR ‐FL inhibits these processes. Taken together, these findings demonstrate that p75 NTR ‐CTF and p75 NTR ‐FL have opposing functions in melanoma cells, suggesting that the ratio of the two proteins affects the balance between cell death and survival. The presence of distinct p75 NTR proteolytic fragments may affect biological outcomes in tumor cells." @default.
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• W3110187975 date "2020-12-16" @default.
• W3110187975 modified "2023-10-18" @default.
• W3110187975 title "The p75 ^NTR and its carboxyl‐terminal fragment exert opposing effects on melanoma cell proliferation and apoptosis via modulation of the NF‐κB pathway" @default.
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• W3110187975 doi "https://doi.org/10.1002/2211-5463.13047" @default.
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