Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110216478> ?p ?o ?g. }
- W3110216478 endingPage "881" @default.
- W3110216478 startingPage "873" @default.
- W3110216478 abstract "Abstract The pandemic outbreak of coronavirus disease 2019 (COVID‐19) across the world has led to millions of infection cases and caused a global public health crisis. Current research suggests that SARS‐CoV‐2 is a highly contagious coronavirus that spreads rapidly through communities. To understand the mechanisms of viral replication, it is imperative to investigate coronavirus viral replicase, a huge protein complex comprising up to 16 viral nonstructural and associated host proteins, which is the most promising antiviral target for inhibiting viral genome replication and transcription. Recently, several components of the viral replicase complex in SARS‐CoV‐2 have been solved to provide a basis for the design of new antiviral therapeutics. Here, we report the crystal structure of the SARS‐CoV‐2 nsp7+8 tetramer, which comprises two copies of each protein representing nsp7's full‐length and the C‐terminus of nsp8 owing to N‐terminus proteolysis during the process of crystallization. We also identified a long helical extension and highly flexible N‐terminal domain of nsp8, which is preferred for interacting with single‐stranded nucleic acids." @default.
- W3110216478 created "2020-12-07" @default.
- W3110216478 creator A5017931611 @default.
- W3110216478 creator A5027475930 @default.
- W3110216478 creator A5029852189 @default.
- W3110216478 creator A5064548129 @default.
- W3110216478 creator A5088315391 @default.
- W3110216478 date "2021-02-25" @default.
- W3110216478 modified "2023-09-30" @default.
- W3110216478 title "Nonstructural protein 7 and 8 complexes of SARS‐CoV‐2" @default.
- W3110216478 cites W1539796472 @default.
- W3110216478 cites W1968574388 @default.
- W3110216478 cites W1973648815 @default.
- W3110216478 cites W2004837257 @default.
- W3110216478 cites W2009299532 @default.
- W3110216478 cites W2025583562 @default.
- W3110216478 cites W2031648434 @default.
- W3110216478 cites W2034313472 @default.
- W3110216478 cites W2035503835 @default.
- W3110216478 cites W2042669556 @default.
- W3110216478 cites W2049814812 @default.
- W3110216478 cites W2098374907 @default.
- W3110216478 cites W2108226298 @default.
- W3110216478 cites W2108921801 @default.
- W3110216478 cites W2134092129 @default.
- W3110216478 cites W2159857626 @default.
- W3110216478 cites W2163341755 @default.
- W3110216478 cites W2168364606 @default.
- W3110216478 cites W2171291163 @default.
- W3110216478 cites W2180229411 @default.
- W3110216478 cites W2463634719 @default.
- W3110216478 cites W2804822363 @default.
- W3110216478 cites W2914796231 @default.
- W3110216478 cites W2999409984 @default.
- W3110216478 cites W3001897055 @default.
- W3110216478 cites W3003464757 @default.
- W3110216478 cites W3004280078 @default.
- W3110216478 cites W3004318991 @default.
- W3110216478 cites W3009906937 @default.
- W3110216478 cites W3011701533 @default.
- W3110216478 cites W3015404155 @default.
- W3110216478 cites W3017680297 @default.
- W3110216478 cites W3022734398 @default.
- W3110216478 cites W3025511956 @default.
- W3110216478 cites W3027231799 @default.
- W3110216478 cites W3046218096 @default.
- W3110216478 cites W41083760 @default.
- W3110216478 doi "https://doi.org/10.1002/pro.4046" @default.
- W3110216478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7980517" @default.
- W3110216478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33594727" @default.
- W3110216478 hasPublicationYear "2021" @default.
- W3110216478 type Work @default.
- W3110216478 sameAs 3110216478 @default.
- W3110216478 citedByCount "10" @default.
- W3110216478 countsByYear W31102164782021 @default.
- W3110216478 countsByYear W31102164782022 @default.
- W3110216478 countsByYear W31102164782023 @default.
- W3110216478 crossrefType "journal-article" @default.
- W3110216478 hasAuthorship W3110216478A5017931611 @default.
- W3110216478 hasAuthorship W3110216478A5027475930 @default.
- W3110216478 hasAuthorship W3110216478A5029852189 @default.
- W3110216478 hasAuthorship W3110216478A5064548129 @default.
- W3110216478 hasAuthorship W3110216478A5088315391 @default.
- W3110216478 hasBestOaLocation W31102164781 @default.
- W3110216478 hasConcept C104317684 @default.
- W3110216478 hasConcept C10852380 @default.
- W3110216478 hasConcept C140704245 @default.
- W3110216478 hasConcept C142724271 @default.
- W3110216478 hasConcept C159047783 @default.
- W3110216478 hasConcept C181199279 @default.
- W3110216478 hasConcept C2522874641 @default.
- W3110216478 hasConcept C2777648638 @default.
- W3110216478 hasConcept C2778886173 @default.
- W3110216478 hasConcept C2779134260 @default.
- W3110216478 hasConcept C2780879997 @default.
- W3110216478 hasConcept C3008058167 @default.
- W3110216478 hasConcept C41258723 @default.
- W3110216478 hasConcept C524204448 @default.
- W3110216478 hasConcept C54355233 @default.
- W3110216478 hasConcept C55493867 @default.
- W3110216478 hasConcept C58475186 @default.
- W3110216478 hasConcept C67705224 @default.
- W3110216478 hasConcept C70721500 @default.
- W3110216478 hasConcept C71924100 @default.
- W3110216478 hasConcept C86803240 @default.
- W3110216478 hasConceptScore W3110216478C104317684 @default.
- W3110216478 hasConceptScore W3110216478C10852380 @default.
- W3110216478 hasConceptScore W3110216478C140704245 @default.
- W3110216478 hasConceptScore W3110216478C142724271 @default.
- W3110216478 hasConceptScore W3110216478C159047783 @default.
- W3110216478 hasConceptScore W3110216478C181199279 @default.
- W3110216478 hasConceptScore W3110216478C2522874641 @default.
- W3110216478 hasConceptScore W3110216478C2777648638 @default.
- W3110216478 hasConceptScore W3110216478C2778886173 @default.
- W3110216478 hasConceptScore W3110216478C2779134260 @default.
- W3110216478 hasConceptScore W3110216478C2780879997 @default.
- W3110216478 hasConceptScore W3110216478C3008058167 @default.
- W3110216478 hasConceptScore W3110216478C41258723 @default.