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• W3110315092 startingPage "104483" @default.
• W3110315092 abstract "Two series of 5-aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety were identified as competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors. Among the compounds studied, 5g was found to have the best PTP1B inhibitory potency (IC50 = 2.66 ± 0.16 µM) and the best cell division cycle 25 homolog B (CDC25B) inhibitory potency (IC50 = 0.25 ± 0.02 µM). Enzymatic data together with molecular modeling results demonstrated that the introduction of a sec-butyl group at the 2-position of the carboxyl group remarkably improved the PTP1B inhibitory activity." @default.
• W3110315092 created "2020-12-07" @default.
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• W3110315092 date "2021-01-01" @default.
• W3110315092 modified "2023-10-17" @default.
• W3110315092 title "5-Aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety as potential PTP1B inhibitors" @default.
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• W3110315092 doi "https://doi.org/10.1016/j.bioorg.2020.104483" @default.
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