FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110362437> ?p ?o ?g. }

• W3110362437 abstract "Could COVID-19 infection be treated without any antivirals? The cholinergic pathway is long implicated in inflammation regulation. ACE2 is the first known receptor implicated in SARS-coV2 entry and probably upregulated in smoking patients classifying smoking behavior to be a risk factor of COVID-19 severity. SARS-coV2 as SARS-coV induces micro-hypoxia states leading to inflammation processes that aggravate to ARDS in lung and ACVD in brain. Less attention is based on nAchRs as it could be activated in the cholinergic pathway and be the source of many inflammation syndromes. α-7 nAchR macrophages are key ubiquitous innate immune messengers could also be initiators of preinflammation state as they co-express both ACE2 R on cell membrane and α-7 nAchR. The same mechanism is supposed to be applied to CNS and leading to indirect route and brain damages. Order of organs targeted and mechanisms involved by SARS-CoV2 are in actual debate. Lungs are first direct target of the virus but correlations between other targeted organs such as heart, kidney, intestine, liver, bone marrow and brain differ with patients. Focusing on dual lung induced neurologic disorders and plausible risk factors that leads to ARDS and ACVD, we propose a nicotinic approach leading to a possible source of MAS involved : key nexus HIF-1α. Also in COVID-19, many cases reported an hypoxemic debut in brain. HIF-1a is a proven connector in lung and contribute to angiogenesis and cell survival via VEGF pathway. Preventing cytokine storm probably involves HIF-1α synthesis via macrophage TLR4 possible upregulation. Nicotine and α-7 nAchR agonists could participate in reducing LPS-induced TNFa and cytokine release via macrophage TLR4 relay and lead to neuroprotection. As oxidized low-density lipoprotein can induce blood vessels inflammation and promote atherosclerosis. HIF-1α protein accumulation in human macrophages through a mechanism involving ROS production could explain cardiovascular risks factors observed in COVID-19. Thus, COVID-19 resolution is probably a 4 variables equation including first, the imbalance ACE2/ACE. Second, the imbalance TLR2/TLR4. Third, HIF-1a induced connector regulation. Fourth, α-7 nAchR finest regulation." @default.
• W3110362437 created "2020-12-07" @default.
• W3110362437 creator A5008758795 @default.
• W3110362437 creator A5010893239 @default.
• W3110362437 date "2020-01-01" @default.
• W3110362437 modified "2023-10-16" @default.
• W3110362437 title "A-7 nAchR Macrophages and Nicotine Approach in Neuroprotection to COVID-19 4 Variables Equation?" @default.
• W3110362437 cites W1444346221 @default.
• W3110362437 cites W1491850598 @default.
• W3110362437 cites W1507516689 @default.
• W3110362437 cites W1511458250 @default.
• W3110362437 cites W1542715374 @default.
• W3110362437 cites W1577070562 @default.
• W3110362437 cites W1828344348 @default.
• W3110362437 cites W1907832415 @default.
• W3110362437 cites W1965191651 @default.
• W3110362437 cites W1985918099 @default.
• W3110362437 cites W1986233605 @default.
• W3110362437 cites W1991980674 @default.
• W3110362437 cites W1993373360 @default.
• W3110362437 cites W1995525413 @default.
• W3110362437 cites W1996168249 @default.
• W3110362437 cites W1997309353 @default.
• W3110362437 cites W2000178052 @default.
• W3110362437 cites W2002846788 @default.
• W3110362437 cites W2005190067 @default.
• W3110362437 cites W2019057590 @default.
• W3110362437 cites W2019221616 @default.
• W3110362437 cites W2028637317 @default.
• W3110362437 cites W2029151357 @default.
• W3110362437 cites W2030662122 @default.
• W3110362437 cites W2033797312 @default.
• W3110362437 cites W2034074829 @default.
• W3110362437 cites W2034160322 @default.
• W3110362437 cites W2037636746 @default.
• W3110362437 cites W2042821764 @default.
• W3110362437 cites W2043163613 @default.
• W3110362437 cites W2046037981 @default.
• W3110362437 cites W2052845314 @default.
• W3110362437 cites W2065853494 @default.
• W3110362437 cites W2069368135 @default.
• W3110362437 cites W2073295417 @default.
• W3110362437 cites W2075323804 @default.
• W3110362437 cites W2080274549 @default.
• W3110362437 cites W2086246203 @default.
• W3110362437 cites W2086265500 @default.
• W3110362437 cites W2087885233 @default.
• W3110362437 cites W2087893789 @default.
• W3110362437 cites W2099855781 @default.
• W3110362437 cites W2111850449 @default.
• W3110362437 cites W2117768550 @default.
• W3110362437 cites W2122212067 @default.
• W3110362437 cites W2123950558 @default.
• W3110362437 cites W2128617253 @default.
• W3110362437 cites W2138548105 @default.
• W3110362437 cites W2141107265 @default.
• W3110362437 cites W2141249815 @default.
• W3110362437 cites W2148714561 @default.
• W3110362437 cites W2148776731 @default.
• W3110362437 cites W2154445813 @default.
• W3110362437 cites W2295774726 @default.
• W3110362437 cites W2326801536 @default.
• W3110362437 cites W2341328555 @default.
• W3110362437 cites W2427261560 @default.
• W3110362437 cites W2579198758 @default.
• W3110362437 cites W2597451758 @default.
• W3110362437 cites W2599085091 @default.
• W3110362437 cites W2599822883 @default.
• W3110362437 cites W2609650349 @default.
• W3110362437 cites W2616549989 @default.
• W3110362437 cites W2743227965 @default.
• W3110362437 cites W2750705884 @default.
• W3110362437 cites W2766287142 @default.
• W3110362437 cites W2767064823 @default.
• W3110362437 cites W2808309912 @default.
• W3110362437 cites W2885396126 @default.
• W3110362437 cites W3010897008 @default.
• W3110362437 cites W3012796370 @default.
• W3110362437 cites W3013270768 @default.
• W3110362437 cites W3014310029 @default.
• W3110362437 cites W3014352840 @default.
• W3110362437 cites W3016127017 @default.
• W3110362437 cites W3016395780 @default.
• W3110362437 cites W3016580728 @default.
• W3110362437 cites W3020468057 @default.
• W3110362437 cites W3022970339 @default.
• W3110362437 cites W3023822056 @default.
• W3110362437 cites W3023982717 @default.
• W3110362437 cites W3024442031 @default.
• W3110362437 cites W3025860919 @default.
• W3110362437 cites W3028582054 @default.
• W3110362437 cites W3031785952 @default.
• W3110362437 cites W3031881950 @default.
• W3110362437 cites W3033356077 @default.
• W3110362437 cites W3036725008 @default.
• W3110362437 cites W3044786422 @default.
• W3110362437 cites W3048557052 @default.
• W3110362437 cites W3174305430 @default.
• W3110362437 doi "https://doi.org/10.2139/ssrn.3674367" @default.
• W3110362437 hasPublicationYear "2020" @default.

• next