FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110363351> ?p ?o ?g. }

• W3110363351 abstract "Abstract Introduction and purpose Data on the survival of patients with moderate aortic stenosis (AS) is conflicting. The purpose of the current analysis was to assess survival of moderate AS patients. Methods SHARE is an historical retrospective cohort of all cardiovascular patients evaluated in an Israeli tertiary hospital between 2007 and 2019. The current analysis included all patients who underwent echocardiographic evaluation. Aortic stenosis severity was extracted for all patients from the echocardiographic reports. All-cause mortality and was available for all patients. Subjects with severe AS or aortic valve replacement were excluded from the analysis. Results Cohort included 97,561 subjects of whom 42,187 (43.2%) were outpatients. Final cohort included 93,889 patients with a mean age of 66±17 (58% men). There were 2,949 (3%) with moderate AS. During a median follow up of 52 [IQR 22–89] months 17,173 (18%) patients died. Kaplan-Meier survival analysis demonstrated worse cumulative probability of death of 51%±2% vs. 20%±0% at 5 years for patients with moderate AS vs. mild or no AS, respectively (p Log rank &lt;0.001). Sub-analysis of 32,745 patients for whom clinical laboratory and medication data was available yielded consistent results in a comprehensive multivariate model such that patients with moderate AS (N=1,381) were 26% more likely to die (95% CI: 1.17–1.37, p&lt;0.0001). Finally, a propensity score matching of patients with moderate AS and controls with no or mild AS (N=1,381) successfully demonstrated that patients with moderate AS were 40% more likely to die during follow up (95% CI 1.25–1.57, p&lt;0.001; FIGURE). Four-years mortality rates were 2 fold higher for patients with moderate AS compared with controls (OR = 1.96, 95% CI 1.6–2.4, p&lt;0.001). Interaction analysis demonstrated that the association of moderate AS with survival was not dependent on left ventricular ejection fraction. Conclusion Moderate AS is associated with worse survival. Our findings underscore the importance of careful clinical observation as well as the need for further studies. Figure 1 Funding Acknowledgement Type of funding source: None" @default.
• W3110363351 created "2020-12-07" @default.
• W3110363351 creator A5009577892 @default.
• W3110363351 creator A5018046522 @default.
• W3110363351 creator A5026476092 @default.
• W3110363351 creator A5044636670 @default.
• W3110363351 creator A5047980929 @default.
• W3110363351 creator A5062963675 @default.
• W3110363351 creator A5066287691 @default.
• W3110363351 creator A5071162611 @default.
• W3110363351 creator A5083223444 @default.
• W3110363351 creator A5087690567 @default.
• W3110363351 creator A5088702766 @default.
• W3110363351 date "2020-11-01" @default.
• W3110363351 modified "2023-10-17" @default.
• W3110363351 title "Survival of patients with moderate aortic stenosis: propensity score matching analysis" @default.
• W3110363351 doi "https://doi.org/10.1093/ehjci/ehaa946.1891" @default.
• W3110363351 hasPublicationYear "2020" @default.
• W3110363351 type Work @default.
• W3110363351 sameAs 3110363351 @default.
• W3110363351 citedByCount "0" @default.
• W3110363351 crossrefType "journal-article" @default.
• W3110363351 hasAuthorship W3110363351A5009577892 @default.
• W3110363351 hasAuthorship W3110363351A5018046522 @default.
• W3110363351 hasAuthorship W3110363351A5026476092 @default.
• W3110363351 hasAuthorship W3110363351A5044636670 @default.
• W3110363351 hasAuthorship W3110363351A5047980929 @default.
• W3110363351 hasAuthorship W3110363351A5062963675 @default.
• W3110363351 hasAuthorship W3110363351A5066287691 @default.
• W3110363351 hasAuthorship W3110363351A5071162611 @default.
• W3110363351 hasAuthorship W3110363351A5083223444 @default.
• W3110363351 hasAuthorship W3110363351A5087690567 @default.
• W3110363351 hasAuthorship W3110363351A5088702766 @default.
• W3110363351 hasConcept C10515644 @default.
• W3110363351 hasConcept C126322002 @default.
• W3110363351 hasConcept C141071460 @default.
• W3110363351 hasConcept C164705383 @default.
• W3110363351 hasConcept C167135981 @default.
• W3110363351 hasConcept C17923572 @default.
• W3110363351 hasConcept C2776570981 @default.
• W3110363351 hasConcept C2780007028 @default.
• W3110363351 hasConcept C2780714102 @default.
• W3110363351 hasConcept C2781414266 @default.
• W3110363351 hasConcept C38180746 @default.
• W3110363351 hasConcept C66339696 @default.
• W3110363351 hasConcept C71924100 @default.
• W3110363351 hasConcept C72563966 @default.
• W3110363351 hasConceptScore W3110363351C10515644 @default.
• W3110363351 hasConceptScore W3110363351C126322002 @default.
• W3110363351 hasConceptScore W3110363351C141071460 @default.
• W3110363351 hasConceptScore W3110363351C164705383 @default.
• W3110363351 hasConceptScore W3110363351C167135981 @default.
• W3110363351 hasConceptScore W3110363351C17923572 @default.
• W3110363351 hasConceptScore W3110363351C2776570981 @default.
• W3110363351 hasConceptScore W3110363351C2780007028 @default.
• W3110363351 hasConceptScore W3110363351C2780714102 @default.
• W3110363351 hasConceptScore W3110363351C2781414266 @default.
• W3110363351 hasConceptScore W3110363351C38180746 @default.
• W3110363351 hasConceptScore W3110363351C66339696 @default.
• W3110363351 hasConceptScore W3110363351C71924100 @default.
• W3110363351 hasConceptScore W3110363351C72563966 @default.
• W3110363351 hasLocation W31103633511 @default.
• W3110363351 hasOpenAccess W3110363351 @default.
• W3110363351 hasPrimaryLocation W31103633511 @default.
• W3110363351 hasRelatedWork W11635444 @default.
• W3110363351 hasRelatedWork W11921753 @default.
• W3110363351 hasRelatedWork W16473077 @default.
• W3110363351 hasRelatedWork W20829825 @default.
• W3110363351 hasRelatedWork W2344133 @default.
• W3110363351 hasRelatedWork W4290026 @default.
• W3110363351 hasRelatedWork W4934457 @default.
• W3110363351 hasRelatedWork W624662 @default.
• W3110363351 hasRelatedWork W8633299 @default.
• W3110363351 hasRelatedWork W16411853 @default.
• W3110363351 isParatext "false" @default.
• W3110363351 isRetracted "false" @default.
• W3110363351 magId "3110363351" @default.
• W3110363351 workType "article" @default.