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- W3110367533 abstract "Purpose: The aim of the present study was to establish cerebral white matter (WM)microstructural changes in pure maxillofacial (MF) trauma injuries and the associatedneurocognitive deficits in an effort to improve the prognostic values of Diffusion TensorImaging (DTI) parameters in mild traumatic brain injury (mTBI) care. Materials andMethods: A prospective review of 21 patients with pure MF was included in the studyalong with 21 healthy control participants. Magnetic resonance imaging (MRI) andstructural DTI were performed on all patients using a 3T MRI (within 24 hours from thetime of trauma). The DTI values were registered to the ICBM DTI-81 white matteratlas. Fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD)values were automatically calculated for 50 white matter tracts. Comprehensiveneuropsychological evaluation was done using the Screening – NeuropsychologicalAssessment Battery (SNAB) within the same admission. After 6 months in average(chronic phase), patients were subjected for a repeat of DTI scan andneuropsychological evaluation. Descriptive statistics were used for the demographicdata, and a paired t – test and repeated measure analysis of variance were used toestablish the intergroup differences and susceptibility. Results: The included patientswere relatively young adults, with a mean age of 29 ± 8.1 years and 13.0 ± 1.2 years ofeducation. Of the 21 patients, 5 (24%) had MF injuries involving the soft tissue, 2 (9%)had MF injury on upper third region, 12 (57%) had injuries at middle third and 2 (10%)were injured on lower third. Of the 21 patients with MF injuries, none had intracranialabnormalities found on the admission CT scan. Executive function and attention weresignificantly altered across the time points, with patients with MF injury doing poorly at ivbaseline with signs of a slowed recovery 6 months later. Wider variety of WM tractsinjury responses were noted with radiological evidence of reactive astrogliosis,vasogenic and cytotoxic edema in the acute phase and subsequent demyelination anddegeneration of WM tracts over time. The pathogenic processes were stronglycorrelated with the neuropsychological deficits seen in MF patient group. Conclusion:The unique DTI parameters (both at acute and follow up) enable better prognosticationof neuropsychological outcomes in patients with MF injuries.Keywords: maxillofacial injury; diffusion tensor imaging; microstructural changes;traumatic brain injury; neuropsychology" @default.
- W3110367533 created "2020-12-07" @default.
- W3110367533 creator A5001037394 @default.
- W3110367533 date "2018-01-01" @default.
- W3110367533 modified "2023-09-27" @default.
- W3110367533 title "Cerebral white matter microstructural changes in pure maxillofacial trauma and its associated neuropsychological outcome amongst Malaysian / Sujesh Sreedharan" @default.
- W3110367533 hasPublicationYear "2018" @default.
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