Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110374578> ?p ?o ?g. }
- W3110374578 endingPage "295" @default.
- W3110374578 startingPage "273" @default.
- W3110374578 abstract "The complement system is essential for immune defence against infection and modulation of proinflammatory responses. Activation of the terminal pathway of complement triggers formation of the membrane attack complex (MAC), a multi-protein pore that punctures membranes. Recent advances in structural biology, specifically cryo-electron microscopy (cryoEM), have provided atomic resolution snapshots along the pore formation pathway. These structures have revealed dramatic conformational rearrangements that enable assembly and membrane rupture. Here we review the structural basis for MAC formation and show how soluble proteins transition into a giant β-barrel pore. We also discuss regulatory complexes of the terminal pathway and their impact on structure-guided drug discovery of complement therapeutics." @default.
- W3110374578 created "2020-12-07" @default.
- W3110374578 creator A5001533319 @default.
- W3110374578 creator A5026555367 @default.
- W3110374578 creator A5041911815 @default.
- W3110374578 creator A5077066530 @default.
- W3110374578 date "2020-12-01" @default.
- W3110374578 modified "2023-09-27" @default.
- W3110374578 title "How Structures of Complement Complexes Guide Therapeutic Design" @default.
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