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• W3110423902 abstract "<h3>Background</h3> Binding of donor-specific antibodies (DSAs) to kidney allograft endothelial cells that does not activate the classic complement cascade can trigger the recruitment of innate immune effectors, including NK cells. Activated NK cells contribute to microvascular inflammation leading to chronic antibody-mediated rejection (AMR). Recipient NK cells can also trigger antibody-independent microvascular inflammation by sensing the absence of self HLA class I molecules (“missing self”) on allograft endothelial cells. This translational study investigated whether the condition of missing self amplifies DSA-dependent NK cell activation to worsen chronic AMR. <h3>Methods and Results</h3> Among 1682 kidney transplant recipients who underwent an allograft biopsy at Lyon University Hospital between 2004 and 2017, 135 fulfilled the diagnostic criteria for AMR and were enrolled in the study. Patients with complement-fixing DSAs identified by a positive C3d binding assay (<i>n</i>=73, 54%) had a higher risk of transplant failure (<i>P</i>=0.002). Among the remaining patients with complement-independent chronic AMR (<i>n</i>=62, 46%), those in whom missing self was identified through donor and recipient genotyping exhibited worse allograft survival (<i>P</i>=0.02). In multivariable analysis, only proteinuria (HR: 7.24; <i>P</i>=0.01) and the presence of missing self (HR: 3.57; <i>P</i>=0.04) were independent predictors for transplant failure following diagnosis of chronic AMR. Cocultures of human NK cells and endothelial cells confirmed that addition of missing self to DSA-induced NK cell activation increased endothelial damage. <h3>Conclusions</h3> The assessment of missing self at the time of diagnosis of chronic AMR identifies patients at higher risk for kidney transplant failure." @default.
• W3110423902 created "2020-12-07" @default.
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• W3110423902 date "2020-11-25" @default.
• W3110423902 modified "2023-10-14" @default.
• W3110423902 title "Missing Self-Induced Activation of NK Cells Combines with Non-Complement-Fixing Donor-Specific Antibodies to Accelerate Kidney Transplant Loss in Chronic Antibody-Mediated Rejection" @default.
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• W3110423902 cites W1985987855 @default.
• W3110423902 cites W2004822121 @default.
• W3110423902 cites W2012173650 @default.
• W3110423902 cites W2020163905 @default.
• W3110423902 cites W2026399893 @default.
• W3110423902 cites W2039638023 @default.
• W3110423902 cites W2048250100 @default.
• W3110423902 cites W2051896332 @default.
• W3110423902 cites W2075805721 @default.
• W3110423902 cites W2092382141 @default.
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• W3110423902 cites W2149701756 @default.
• W3110423902 cites W2163559860 @default.
• W3110423902 cites W2171400507 @default.
• W3110423902 cites W2172432588 @default.
• W3110423902 cites W2280520978 @default.
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• W3110423902 doi "https://doi.org/10.1681/asn.2020040433" @default.
• W3110423902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8054908" @default.
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