FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110426579> ?p ?o ?g. }

• W3110426579 endingPage "12335" @default.
• W3110426579 startingPage "12326" @default.
• W3110426579 abstract "Abstract Circular RNAs (circRNAs) are a class of noncoding RNAs, generated from pre-mRNAs by circular splicing of exons and functionally largely uncharacterized. Here we report on the design, expression, and characterization of artificial circRNAs that act as protein sponges, specifically binding and functionally inactivating hnRNP (heterogeneous nuclear ribonucleoprotein) L. HnRNP L regulates alternative splicing, depending on short CA-rich RNA elements. We demonstrate that designer hnRNP L-sponge circRNAs with CA-repeat or CA-rich sequence clusters can efficiently and specifically modulate splicing-regulatory networks in mammalian cells, including alternative splicing patterns and the cellular distribution of a splicing factor. This new strategy can in principle be applied to any RNA-binding protein, opening up new therapeutic strategies in molecular medicine." @default.
• W3110426579 created "2020-12-07" @default.
• W3110426579 creator A5000764988 @default.
• W3110426579 creator A5044148552 @default.
• W3110426579 creator A5049369785 @default.
• W3110426579 creator A5081899611 @default.
• W3110426579 date "2020-11-24" @default.
• W3110426579 modified "2023-10-06" @default.
• W3110426579 title "Design and application of circular RNAs with protein-sponge function" @default.
• W3110426579 cites W1777808916 @default.
• W3110426579 cites W1934757642 @default.
• W3110426579 cites W1967817963 @default.
• W3110426579 cites W1975909559 @default.
• W3110426579 cites W1979118104 @default.
• W3110426579 cites W2008976996 @default.
• W3110426579 cites W2021862696 @default.
• W3110426579 cites W2029989907 @default.
• W3110426579 cites W2031593782 @default.
• W3110426579 cites W2033799707 @default.
• W3110426579 cites W2034305079 @default.
• W3110426579 cites W2058835062 @default.
• W3110426579 cites W2064165694 @default.
• W3110426579 cites W2085245358 @default.
• W3110426579 cites W2087815448 @default.
• W3110426579 cites W2110304444 @default.
• W3110426579 cites W2129401282 @default.
• W3110426579 cites W2133260401 @default.
• W3110426579 cites W2141708499 @default.
• W3110426579 cites W2147806662 @default.
• W3110426579 cites W2148972157 @default.
• W3110426579 cites W2169456326 @default.
• W3110426579 cites W2175098699 @default.
• W3110426579 cites W2514334418 @default.
• W3110426579 cites W2625817416 @default.
• W3110426579 cites W2744268790 @default.
• W3110426579 cites W2798204307 @default.
• W3110426579 cites W2811482166 @default.
• W3110426579 cites W2936259264 @default.
• W3110426579 cites W2949344281 @default.
• W3110426579 cites W2951344785 @default.
• W3110426579 cites W2967043226 @default.
• W3110426579 cites W3020855961 @default.
• W3110426579 cites W4240367950 @default.
• W3110426579 cites W7669837 @default.
• W3110426579 doi "https://doi.org/10.1093/nar/gkaa1085" @default.
• W3110426579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7708053" @default.
• W3110426579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33231682" @default.
• W3110426579 hasPublicationYear "2020" @default.
• W3110426579 type Work @default.
• W3110426579 sameAs 3110426579 @default.
• W3110426579 citedByCount "27" @default.
• W3110426579 countsByYear W31104265792021 @default.
• W3110426579 countsByYear W31104265792022 @default.
• W3110426579 countsByYear W31104265792023 @default.
• W3110426579 crossrefType "journal-article" @default.
• W3110426579 hasAuthorship W3110426579A5000764988 @default.
• W3110426579 hasAuthorship W3110426579A5044148552 @default.
• W3110426579 hasAuthorship W3110426579A5049369785 @default.
• W3110426579 hasAuthorship W3110426579A5081899611 @default.
• W3110426579 hasBestOaLocation W31104265791 @default.
• W3110426579 hasConcept C104317684 @default.
• W3110426579 hasConcept C159194896 @default.
• W3110426579 hasConcept C194583182 @default.
• W3110426579 hasConcept C2775893923 @default.
• W3110426579 hasConcept C2908584439 @default.
• W3110426579 hasConcept C2909472194 @default.
• W3110426579 hasConcept C36823959 @default.
• W3110426579 hasConcept C41282012 @default.
• W3110426579 hasConcept C42576000 @default.
• W3110426579 hasConcept C54355233 @default.
• W3110426579 hasConcept C54458228 @default.
• W3110426579 hasConcept C67705224 @default.
• W3110426579 hasConcept C70721500 @default.
• W3110426579 hasConcept C75934600 @default.
• W3110426579 hasConcept C86803240 @default.
• W3110426579 hasConcept C95444343 @default.
• W3110426579 hasConceptScore W3110426579C104317684 @default.
• W3110426579 hasConceptScore W3110426579C159194896 @default.
• W3110426579 hasConceptScore W3110426579C194583182 @default.
• W3110426579 hasConceptScore W3110426579C2775893923 @default.
• W3110426579 hasConceptScore W3110426579C2908584439 @default.
• W3110426579 hasConceptScore W3110426579C2909472194 @default.
• W3110426579 hasConceptScore W3110426579C36823959 @default.
• W3110426579 hasConceptScore W3110426579C41282012 @default.
• W3110426579 hasConceptScore W3110426579C42576000 @default.
• W3110426579 hasConceptScore W3110426579C54355233 @default.
• W3110426579 hasConceptScore W3110426579C54458228 @default.
• W3110426579 hasConceptScore W3110426579C67705224 @default.
• W3110426579 hasConceptScore W3110426579C70721500 @default.
• W3110426579 hasConceptScore W3110426579C75934600 @default.
• W3110426579 hasConceptScore W3110426579C86803240 @default.
• W3110426579 hasConceptScore W3110426579C95444343 @default.
• W3110426579 hasFunder F4320320879 @default.
• W3110426579 hasFunder F4320332999 @default.
• W3110426579 hasIssue "21" @default.
• W3110426579 hasLocation W31104265791 @default.
• W3110426579 hasLocation W31104265792 @default.
• W3110426579 hasOpenAccess W3110426579 @default.

• next