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• W3110439708 endingPage "143896" @default.
• W3110439708 startingPage "143896" @default.
• W3110439708 abstract "Early life stages of fish are highly sensitive to crude oil exposure and thus, short term exposures during critical developmental periods could have detrimental consequences for juvenile survival. Here we administered crude oil to Atlantic haddock ( Melanogrammus aeglefinus ) in short term (3-day) exposures at two developmental time periods: before first heartbeat, from gastrulation to cardiac cone stage ( early ), and from first heartbeat to one day before hatching ( late ). A frequent sampling regime enabled us to determine immediate PAH uptake, metabolite formation and gene expression changes. In general, the embryotoxic consequences of an oil exposure were more severe in the early exposure animals. Oil droplets on the eggshell resulted in severe cardiac and craniofacial abnormalities in the highest treatments. Gene expression changes of Cytochrome 1 a, b, c and d ( cyp1a , b , c , d ), Bone morphogenetic protein 10 ( bmp10 ), ABC transporter b1 ( abcb1 ) and Rh-associated G-protein ( rhag ) were linked to PAH uptake, occurrence of metabolites of phenanthrene and developmental and functional abnormalities. We detected circulation-independent, oil-induced gene expression changes and separated phenotypes linked to proliferation, growth and disruption of formation events at early and late developmental stages. Changes in bmp10 expression suggest a direct oil-induced effect on calcium homeostasis. Localized expression of rhag propose an impact on osmoregulation. Severe eye abnormalities were linked to possible inappropriate overexpression of cyp1b in the eyes. This study gives an increased knowledge about developmentally dependent effects of crude oil toxicity. Thus, our findings provide more knowledge and detail to new and several existing adverse outcome pathways of crude oil toxicity. • Toxicity to dissolved oil was compounded by oil droplet fouling on the eggshell. • Exposure early in development resulted in higher PAH uptake due to lower metabolism resulting in more severe abnormalities. • A rapid and circulation-independent regulation of bmp10 suggested a direct oil-induced effect on calcium homeostasis. • Expression of rhag indicated a direct oil-induced effect on osmoregulatory cells and osmoregulation. • Severe eye abnormalities especially in the late exposure was linked to inappropriate overexpression of cyp1b in the eyes." @default.
• W3110439708 created "2020-12-07" @default.
• W3110439708 creator A5025470657 @default.
• W3110439708 creator A5066872698 @default.
• W3110439708 creator A5069051315 @default.
• W3110439708 creator A5070266756 @default.
• W3110439708 creator A5088775315 @default.
• W3110439708 creator A5088775983 @default.
• W3110439708 date "2021-02-01" @default.
• W3110439708 modified "2023-10-03" @default.
• W3110439708 title "Untangling mechanisms of crude oil toxicity: Linking gene expression, morphology and PAHs at two developmental stages in a cold-water fish" @default.
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