FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110504920> ?p ?o ?g. }

• W3110504920 endingPage "14479" @default.
• W3110504920 startingPage "14471" @default.
• W3110504920 abstract "Acrolein (ACR) is found exogenously as a widespread environmental pollutant and endogenously, where it is thought to be involved as a pathogenic factor in the progression of many pathological conditions. Eliminating ACR by dietary-active substances has been found to be one potential strategy to prevent ACR-associated chronic diseases. This study first compared the scavenging ACR efficacy of four purine alkaloids, theophylline (TP), paraxanthine (PXT), theobromine (TB), and caffeine (CAF), and then, TP, CAF, and their metabolites were investigated for their ability to trap ACR in vivo. Our results indicated that TP, which possesses an −NH moiety at the N-7 position, exhibits the best ACR-trapping capacity in vitro, while CAF has a slight ability to trap ACR due to the substitutions by −CH3 at the N-1, N-3, and N-7 positions. After oral administration of TP or CAF, the ACR adducts of TP and the metabolites of TP or CAF (e.g., mono- and di-ACR-TP, mono-ACR-1,3-DMU, and mono-ACR-1-MU) were detected in urinary samples obtained from both TP- and CAF-treated mouse groups by using ultra-performance liquid chromatography–tandem mass spectrometry. The quantification studies demonstrated that TP and its metabolites significantly trapped ACR in a dose-dependent manner in vivo. Furthermore, we also detected those ACR adducts of TP and TP/CAF’s metabolites in human urine after four cups of green tea (2 g tea leaf/cup) or two cups of coffee (4 g coffee/cup) were consumed per day. Those results indicated that dietary TP or CAF has the potential capacity to scavenge ACR in vivo." @default.
• W3110504920 created "2020-12-07" @default.
• W3110504920 creator A5055362302 @default.
• W3110504920 creator A5063720832 @default.
• W3110504920 creator A5076738427 @default.
• W3110504920 date "2020-11-30" @default.
• W3110504920 modified "2023-09-23" @default.
• W3110504920 title "Trapping Acrolein by Theophylline/Caffeine and Their Metabolites from Green Tea and Coffee in Mice and Humans" @default.
• W3110504920 cites W1523461427 @default.
• W3110504920 cites W1619084549 @default.
• W3110504920 cites W1981162898 @default.
• W3110504920 cites W1983207054 @default.
• W3110504920 cites W1984534858 @default.
• W3110504920 cites W2000888136 @default.
• W3110504920 cites W2008231587 @default.
• W3110504920 cites W2022774773 @default.
• W3110504920 cites W2033201645 @default.
• W3110504920 cites W2033789459 @default.
• W3110504920 cites W2056215168 @default.
• W3110504920 cites W2067179357 @default.
• W3110504920 cites W2074137641 @default.
• W3110504920 cites W2075140569 @default.
• W3110504920 cites W2104880551 @default.
• W3110504920 cites W2157140824 @default.
• W3110504920 cites W2252366261 @default.
• W3110504920 cites W2321397508 @default.
• W3110504920 cites W2524768906 @default.
• W3110504920 cites W2576995931 @default.
• W3110504920 cites W2601931132 @default.
• W3110504920 cites W2891789908 @default.
• W3110504920 cites W2903947388 @default.
• W3110504920 cites W2939030553 @default.
• W3110504920 cites W2981456438 @default.
• W3110504920 cites W2982355791 @default.
• W3110504920 cites W3015383100 @default.
• W3110504920 cites W3048822926 @default.
• W3110504920 doi "https://doi.org/10.1021/acs.jafc.0c05483" @default.
• W3110504920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33253558" @default.
• W3110504920 hasPublicationYear "2020" @default.
• W3110504920 type Work @default.
• W3110504920 sameAs 3110504920 @default.
• W3110504920 citedByCount "4" @default.
• W3110504920 countsByYear W31105049202021 @default.
• W3110504920 countsByYear W31105049202022 @default.
• W3110504920 countsByYear W31105049202023 @default.
• W3110504920 crossrefType "journal-article" @default.
• W3110504920 hasAuthorship W3110504920A5055362302 @default.
• W3110504920 hasAuthorship W3110504920A5063720832 @default.
• W3110504920 hasAuthorship W3110504920A5076738427 @default.
• W3110504920 hasConcept C112705442 @default.
• W3110504920 hasConcept C126322002 @default.
• W3110504920 hasConcept C150903083 @default.
• W3110504920 hasConcept C161790260 @default.
• W3110504920 hasConcept C181199279 @default.
• W3110504920 hasConcept C185592680 @default.
• W3110504920 hasConcept C202751555 @default.
• W3110504920 hasConcept C207001950 @default.
• W3110504920 hasConcept C22979827 @default.
• W3110504920 hasConcept C2777477808 @default.
• W3110504920 hasConcept C2778095195 @default.
• W3110504920 hasConcept C2778162141 @default.
• W3110504920 hasConcept C2778500429 @default.
• W3110504920 hasConcept C2779470414 @default.
• W3110504920 hasConcept C2779765676 @default.
• W3110504920 hasConcept C2780026642 @default.
• W3110504920 hasConcept C2780422782 @default.
• W3110504920 hasConcept C31903555 @default.
• W3110504920 hasConcept C43617362 @default.
• W3110504920 hasConcept C55493867 @default.
• W3110504920 hasConcept C71924100 @default.
• W3110504920 hasConcept C86745063 @default.
• W3110504920 hasConcept C86803240 @default.
• W3110504920 hasConcept C87644729 @default.
• W3110504920 hasConcept C98274493 @default.
• W3110504920 hasConceptScore W3110504920C112705442 @default.
• W3110504920 hasConceptScore W3110504920C126322002 @default.
• W3110504920 hasConceptScore W3110504920C150903083 @default.
• W3110504920 hasConceptScore W3110504920C161790260 @default.
• W3110504920 hasConceptScore W3110504920C181199279 @default.
• W3110504920 hasConceptScore W3110504920C185592680 @default.
• W3110504920 hasConceptScore W3110504920C202751555 @default.
• W3110504920 hasConceptScore W3110504920C207001950 @default.
• W3110504920 hasConceptScore W3110504920C22979827 @default.
• W3110504920 hasConceptScore W3110504920C2777477808 @default.
• W3110504920 hasConceptScore W3110504920C2778095195 @default.
• W3110504920 hasConceptScore W3110504920C2778162141 @default.
• W3110504920 hasConceptScore W3110504920C2778500429 @default.
• W3110504920 hasConceptScore W3110504920C2779470414 @default.
• W3110504920 hasConceptScore W3110504920C2779765676 @default.
• W3110504920 hasConceptScore W3110504920C2780026642 @default.
• W3110504920 hasConceptScore W3110504920C2780422782 @default.
• W3110504920 hasConceptScore W3110504920C31903555 @default.
• W3110504920 hasConceptScore W3110504920C43617362 @default.
• W3110504920 hasConceptScore W3110504920C55493867 @default.
• W3110504920 hasConceptScore W3110504920C71924100 @default.
• W3110504920 hasConceptScore W3110504920C86745063 @default.
• W3110504920 hasConceptScore W3110504920C86803240 @default.
• W3110504920 hasConceptScore W3110504920C87644729 @default.

• next