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- W3110511482 abstract "The concept of adjuvants or adjuvant systems, used in vaccines, exploit evolutionary relationships associated with how the immune system may initially respond to a foreign antigen or pathogen, thus mimicking natural exposure. This is particularly relevant during the non-specific innate stage of the immune response; as such, the quality of this response may dictate specific adaptive responses and conferred memory/protection to that specific antigen or pathogen. Therefore, adjuvants may optimise this response in the most appropriate way for a specific disease. The most commonly used traditional adjuvants are aluminium salts; however, a biodegradable adjuvant, MCT ® , was developed for application in the niche area of allergy immunotherapy (AIT), also in combination with a TLR-4 adjuvant—Monophosphoryl Lipid A (MPL ® )—producing the first adjuvant system approach for AIT in the clinic. In the last decade, the use and effectiveness of MCT ® across a variety of disease models in the preclinical setting highlight it as a promising platform for adjuvant systems, to help overcome the challenges of modern vaccines. A consequence of bringing together, for the first time, a unified view of MCT ® mode-of-action from multiple experiments and adjuvant systems will help facilitate future rational design of vaccines while shaping their success." @default.
- W3110511482 created "2020-12-07" @default.
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- W3110511482 date "2020-11-24" @default.
- W3110511482 modified "2023-10-16" @default.
- W3110511482 title "Shaping Modern Vaccines: Adjuvant Systems Using MicroCrystalline Tyrosine (MCT®)" @default.
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- W3110511482 doi "https://doi.org/10.3389/fimmu.2020.594911" @default.
- W3110511482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7721672" @default.
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- W3110511482 hasPublicationYear "2020" @default.
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