FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110545166> ?p ?o ?g. }

• W3110545166 endingPage "104123" @default.
• W3110545166 startingPage "104123" @default.
• W3110545166 abstract "The ongoing COVID-19 pandemic caused by the coronavirus, SARS-CoV-2, has already caused in excess of 1.25 million deaths worldwide, and the number is increasing. Knowledge of the host transcriptional response against this virus and how the pathways are activated or suppressed compared to other human coronaviruses (SARS-CoV, MERS-CoV) that caused outbreaks previously can help in the identification of potential drugs for the treatment of COVID-19. Hence, we used time point meta-analysis to investigate available SARS-CoV and MERS-CoV in-vitro transcriptome datasets in order to identify the significant genes and pathways that are dysregulated at each time point. The subsequent over-representation analysis (ORA) revealed that several pathways are significantly dysregulated at each time point after both SARS-CoV and MERS-CoV infection. We also performed gene set enrichment analyses of SARS-CoV and MERS-CoV with that of SARS-CoV-2 at the same time point and cell line, the results of which revealed that common pathways are activated and suppressed in all three coronaviruses. Furthermore, an analysis of an in-vivo transcriptomic dataset of COVID-19 patients showed that similar pathways are enriched to those identified in the earlier analyses. Based on these findings, a drug repurposing analysis was performed to identify potential drug candidates for combating COVID-19." @default.
• W3110545166 created "2020-12-07" @default.
• W3110545166 creator A5004792565 @default.
• W3110545166 creator A5027917384 @default.
• W3110545166 creator A5041665731 @default.
• W3110545166 creator A5079391716 @default.
• W3110545166 creator A5088498949 @default.
• W3110545166 date "2021-01-01" @default.
• W3110545166 modified "2023-10-01" @default.
• W3110545166 title "Comparative transcriptome analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify potential pathways for drug repurposing" @default.
• W3110545166 cites W1167592479 @default.
• W3110545166 cites W139404515 @default.
• W3110545166 cites W1507082667 @default.
• W3110545166 cites W1533236567 @default.
• W3110545166 cites W1546747296 @default.
• W3110545166 cites W1887620514 @default.
• W3110545166 cites W1969622888 @default.
• W3110545166 cites W1976741900 @default.
• W3110545166 cites W1977276708 @default.
• W3110545166 cites W1977675750 @default.
• W3110545166 cites W1984940419 @default.
• W3110545166 cites W1989067276 @default.
• W3110545166 cites W1989688078 @default.
• W3110545166 cites W1991450709 @default.
• W3110545166 cites W1991937961 @default.
• W3110545166 cites W1993950582 @default.
• W3110545166 cites W2003306426 @default.
• W3110545166 cites W2007929239 @default.
• W3110545166 cites W2011384549 @default.
• W3110545166 cites W2016921919 @default.
• W3110545166 cites W2017662862 @default.
• W3110545166 cites W2020172485 @default.
• W3110545166 cites W2029831111 @default.
• W3110545166 cites W2035618305 @default.
• W3110545166 cites W2038465722 @default.
• W3110545166 cites W2041670640 @default.
• W3110545166 cites W2043310790 @default.
• W3110545166 cites W2045784791 @default.
• W3110545166 cites W2051052628 @default.
• W3110545166 cites W2053242101 @default.
• W3110545166 cites W2058584041 @default.
• W3110545166 cites W2061442310 @default.
• W3110545166 cites W2064769568 @default.
• W3110545166 cites W2068854551 @default.
• W3110545166 cites W2070463916 @default.
• W3110545166 cites W2071051432 @default.
• W3110545166 cites W2072099958 @default.
• W3110545166 cites W2073019915 @default.
• W3110545166 cites W2074092657 @default.
• W3110545166 cites W2074634292 @default.
• W3110545166 cites W2074931383 @default.
• W3110545166 cites W2075800587 @default.
• W3110545166 cites W2077847842 @default.
• W3110545166 cites W2085410427 @default.
• W3110545166 cites W2087559885 @default.
• W3110545166 cites W2093313266 @default.
• W3110545166 cites W2094321502 @default.
• W3110545166 cites W2095211056 @default.
• W3110545166 cites W2095574453 @default.
• W3110545166 cites W2096258216 @default.
• W3110545166 cites W2096857883 @default.
• W3110545166 cites W2097926601 @default.
• W3110545166 cites W2098311843 @default.
• W3110545166 cites W2100239923 @default.
• W3110545166 cites W2104548316 @default.
• W3110545166 cites W2107665951 @default.
• W3110545166 cites W2110350344 @default.
• W3110545166 cites W2111058723 @default.
• W3110545166 cites W2112056525 @default.
• W3110545166 cites W2113038532 @default.
• W3110545166 cites W2114104545 @default.
• W3110545166 cites W2120108543 @default.
• W3110545166 cites W2121175754 @default.
• W3110545166 cites W2121604817 @default.
• W3110545166 cites W2127244193 @default.
• W3110545166 cites W2127381372 @default.
• W3110545166 cites W2130410032 @default.
• W3110545166 cites W2131262274 @default.
• W3110545166 cites W2132260239 @default.
• W3110545166 cites W2133422078 @default.
• W3110545166 cites W2137632714 @default.
• W3110545166 cites W2141482843 @default.
• W3110545166 cites W2141877163 @default.
• W3110545166 cites W2144857840 @default.
• W3110545166 cites W2146512944 @default.
• W3110545166 cites W2152082550 @default.
• W3110545166 cites W2152187456 @default.
• W3110545166 cites W2155849479 @default.
• W3110545166 cites W2164013535 @default.
• W3110545166 cites W2166867592 @default.
• W3110545166 cites W2181917879 @default.
• W3110545166 cites W2285062174 @default.
• W3110545166 cites W2334886837 @default.
• W3110545166 cites W2398816925 @default.
• W3110545166 cites W2464706698 @default.
• W3110545166 cites W2465777822 @default.
• W3110545166 cites W2588060879 @default.
• W3110545166 cites W2747597014 @default.

• next