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• W3110574885 abstract "Gastric cancer is the third most common cause of cancer-related death worldwide. Drug resistance is the main inevitable and vital factor leading to a low 5-year survival rate for patients with gastric cancer. Autophagy, as a highly conserved homeostatic pathway, is mainly regulated by different proteins and non-coding RNAs (ncRNAs) and plays dual roles in drug resistance of gastric cancer. Thus, targeting key regulatory nodes in the process of autophagy by small molecule inhibitors or activators has become one of the most promising strategies for the treatment of gastric cancer in recent years. In this review, we provide a systematic summary focusing on the relationship between autophagy and chemotherapy resistance in gastric cancer. We comprehensively discuss the roles and molecular mechanisms of multiple proteins and the emerging ncRNAs including miRNAs and lncRNAs in the regulation of autophagy pathways and gastric cancer chemoresistance. We also summarize the regulatory effects of autophagy inhibitor and activators on gastric cancer chemoresistance. Understanding the vital roles of autophagy in gastric cancer chemoresistance will provide novel opportunities to develop promising therapeutic strategies for gastric cancer." @default.
• W3110574885 created "2020-12-07" @default.
• W3110574885 creator A5017472427 @default.
• W3110574885 creator A5017743504 @default.
• W3110574885 creator A5043950032 @default.
• W3110574885 creator A5057243097 @default.
• W3110574885 creator A5067016639 @default.
• W3110574885 creator A5078000842 @default.
• W3110574885 creator A5078294303 @default.
• W3110574885 date "2020-12-03" @default.
• W3110574885 modified "2023-10-17" @default.
• W3110574885 title "The Role of Autophagy in Gastric Cancer Chemoresistance: Friend or Foe?" @default.
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