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- W3110588124 abstract "Telomerase is regarded as a crucial biomarker for the early diagnosis of malignant tumors and a valuable therapeutic target. In this work, a telomerase-triggered amplification strategy was designed on the basis of a catalyzed hairpin assembly (CHA) for bridging a signal probe of platinum nanoparticles (Pt NPs) anchored on three-dimensional (3D) epoxy-functionalized macroporous carbon (Pt/MPC-COOH) in an ultrasensitive electrochemical biosensor. Pt/MPC-COOH nanomaterials with interconnected macroporous structure not only immobilized hairpin DNA probe 2 (H2) via an amide reaction (Pt/MPC-COOH-H2), but they also generated an obvious electrochemical signal in response to acetaminophen (AP) oxidation. After the introduction of telomerase, telomerase primer (TP) was extended to a telomerase extension product (TEP) with several hexamer repeats (TTAGGG)n to initiate the CHA cycle, leading to signal amplification. Subsequently, with the TEP-triggered CHA cycle amplification strategy, a large amount of Pt/MPC-COOH-H2 was introduced on the electrode surface for the construction of the electrochemical platform, which realized the sensitive detection of telomerase activity from 102 to107 cells mL−1 with a limit of detection (LOD) of 9.02 cells mL−1. This strategy provides a sensitive method for the detection of biomolecules that could be useful for bioanalysis and early clinical diagnoses of diseases." @default.
- W3110588124 created "2020-12-07" @default.
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- W3110588124 date "2021-04-01" @default.
- W3110588124 modified "2023-10-04" @default.
- W3110588124 title "Epoxy-functionalized macroporous carbon with embedded platinum nanoparticles for electrochemical detection of telomerase activity via telomerase-triggered catalytic hairpin assembly" @default.
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- W3110588124 doi "https://doi.org/10.1016/j.talanta.2020.121957" @default.
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