FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110588165> ?p ?o ?g. }

• W3110588165 endingPage "1309" @default.
• W3110588165 startingPage "1302" @default.
• W3110588165 abstract "Infections with Helicobacter pylori are a global challenge. Currently, H. pylori infections are treated systemically, but the eradication rates of the different therapy regimens are declining due to the growing number of bacterial strains resistant to major antibiotics. Here, we present a strategy for the local eradication of H. pylori by the use of Penicillin G sodium (PGS). In vitro experiments revealed that PGS shows high antibiotic activity against resistant strains of Helicobacter pylori with a minimum inhibitory concentration (MIC) of 0.125 μg/ml. In order to provide luminal concentrations above the MIC for longer periods of time, an extended release tablet was developed. Alkalizers were included to prevent acidic degradation of PGS within the tablet matrix. Out of the tested alkalizers MgO, l-Lysine, NaHCO3, and Na2CO3 NaHCO3 provided the strongest rise in pH inside the hydrated matrix when tested in simulated gastric fluid. Better PGS stability can mainly reasoned from that, addition of MgO resulted in high pH values within the matrix, causing basic degradation of PGS. This work is a first step towards the use of extended release tablets containing PGS for the local treatment of H. pylori as a safe and cost-effective alternative to common systemic treatment regimens." @default.
• W3110588165 created "2020-12-07" @default.
• W3110588165 creator A5008645905 @default.
• W3110588165 creator A5014500613 @default.
• W3110588165 creator A5015321016 @default.
• W3110588165 creator A5021734626 @default.
• W3110588165 creator A5033197577 @default.
• W3110588165 creator A5048272596 @default.
• W3110588165 creator A5057894928 @default.
• W3110588165 creator A5077658794 @default.
• W3110588165 creator A5087406737 @default.
• W3110588165 creator A5090820164 @default.
• W3110588165 date "2021-03-01" @default.
• W3110588165 modified "2023-10-18" @default.
• W3110588165 title "Design and Optimization of a Novel Strategy for the Local Treatment of Helicobacter pylori Infections" @default.
• W3110588165 cites W1826452022 @default.
• W3110588165 cites W1930663606 @default.
• W3110588165 cites W196341856 @default.
• W3110588165 cites W1963568522 @default.
• W3110588165 cites W1985025585 @default.
• W3110588165 cites W1997889971 @default.
• W3110588165 cites W1998450697 @default.
• W3110588165 cites W2002650944 @default.
• W3110588165 cites W2006358730 @default.
• W3110588165 cites W2009228936 @default.
• W3110588165 cites W2012750471 @default.
• W3110588165 cites W2021550168 @default.
• W3110588165 cites W2022948175 @default.
• W3110588165 cites W2025621765 @default.
• W3110588165 cites W2036828277 @default.
• W3110588165 cites W2041805992 @default.
• W3110588165 cites W2041895434 @default.
• W3110588165 cites W2046344340 @default.
• W3110588165 cites W2051547833 @default.
• W3110588165 cites W2051993275 @default.
• W3110588165 cites W2060875764 @default.
• W3110588165 cites W2064401560 @default.
• W3110588165 cites W2072145439 @default.
• W3110588165 cites W2074852605 @default.
• W3110588165 cites W2099295435 @default.
• W3110588165 cites W2101089211 @default.
• W3110588165 cites W2101730203 @default.
• W3110588165 cites W2114136388 @default.
• W3110588165 cites W2125030854 @default.
• W3110588165 cites W2141303491 @default.
• W3110588165 cites W2143107875 @default.
• W3110588165 cites W2162632240 @default.
• W3110588165 cites W2188405969 @default.
• W3110588165 cites W2199203801 @default.
• W3110588165 cites W2258266431 @default.
• W3110588165 cites W2262954339 @default.
• W3110588165 cites W2319334300 @default.
• W3110588165 cites W2336356383 @default.
• W3110588165 cites W2408745174 @default.
• W3110588165 cites W2600733912 @default.
• W3110588165 cites W2710651877 @default.
• W3110588165 cites W2735222320 @default.
• W3110588165 cites W2967659494 @default.
• W3110588165 doi "https://doi.org/10.1016/j.xphs.2020.11.021" @default.
• W3110588165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33253724" @default.
• W3110588165 hasPublicationYear "2021" @default.
• W3110588165 type Work @default.
• W3110588165 sameAs 3110588165 @default.
• W3110588165 citedByCount "1" @default.
• W3110588165 countsByYear W31105881652023 @default.
• W3110588165 crossrefType "journal-article" @default.
• W3110588165 hasAuthorship W3110588165A5008645905 @default.
• W3110588165 hasAuthorship W3110588165A5014500613 @default.
• W3110588165 hasAuthorship W3110588165A5015321016 @default.
• W3110588165 hasAuthorship W3110588165A5021734626 @default.
• W3110588165 hasAuthorship W3110588165A5033197577 @default.
• W3110588165 hasAuthorship W3110588165A5048272596 @default.
• W3110588165 hasAuthorship W3110588165A5057894928 @default.
• W3110588165 hasAuthorship W3110588165A5077658794 @default.
• W3110588165 hasAuthorship W3110588165A5087406737 @default.
• W3110588165 hasAuthorship W3110588165A5090820164 @default.
• W3110588165 hasConcept C106487976 @default.
• W3110588165 hasConcept C126322002 @default.
• W3110588165 hasConcept C174802600 @default.
• W3110588165 hasConcept C176947019 @default.
• W3110588165 hasConcept C185592680 @default.
• W3110588165 hasConcept C202751555 @default.
• W3110588165 hasConcept C2776409635 @default.
• W3110588165 hasConcept C43617362 @default.
• W3110588165 hasConcept C4937899 @default.
• W3110588165 hasConcept C501593827 @default.
• W3110588165 hasConcept C55493867 @default.
• W3110588165 hasConcept C71924100 @default.
• W3110588165 hasConcept C86803240 @default.
• W3110588165 hasConcept C89423630 @default.
• W3110588165 hasConcept C98274493 @default.
• W3110588165 hasConceptScore W3110588165C106487976 @default.
• W3110588165 hasConceptScore W3110588165C126322002 @default.
• W3110588165 hasConceptScore W3110588165C174802600 @default.
• W3110588165 hasConceptScore W3110588165C176947019 @default.
• W3110588165 hasConceptScore W3110588165C185592680 @default.
• W3110588165 hasConceptScore W3110588165C202751555 @default.
• W3110588165 hasConceptScore W3110588165C2776409635 @default.

• next